Association Study of rs1421085 and rs9939609 in FTO Gene with Gestational Diabetes in the Arak City
Introduction: Gestational diabetes is defined as hyperglycemia with onset or first diagnosis during pregnancy, with a lower frequency than general diabetes. Overweight and obesity, old age at the time of pregnancy, previous history of gestational diabetes, family history of type 2 diabetes, and race...
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Arak Medical University
2024-03-01
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| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
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| Online Access: | http://jams.arakmu.ac.ir/article-1-7649-en.pdf |
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| author | Parnian Hekmatpou Maryam Maryam Ghanbari Milad Gholami |
| author_facet | Parnian Hekmatpou Maryam Maryam Ghanbari Milad Gholami |
| author_sort | Parnian Hekmatpou |
| collection | DOAJ |
| description | Introduction: Gestational diabetes is defined as hyperglycemia with onset or first diagnosis during pregnancy, with a lower frequency than general diabetes. Overweight and obesity, old age at the time of pregnancy, previous history of gestational diabetes, family history of type 2 diabetes, and race are risk factors for gestational diabetes. Recently, the relationship between two polymorphisms (rs9939609 and rs1421085) of Fat mass and obesity-associated (FTO) gene and the risk of gestational diabetes has been investigated in some studies with conflicting results. Therefore, our aim of the present study was to investigate the association study of rs1421085 and rs9939609 of the FTO gene on gestational diabetes.
Methods: In this case-control study, five cc of peripheral blood was collected from 100 cases with gestational diabetes and 116 control pregnant women from Taleghani Hospital in Arak, and then DNA was extracted. After designing the specific primers, the genotypes were determined by the Tetra ARMS-PCR method. Demographic information was compared with genotypes between the two groups were compared using SNPSTAT software.
Results: A significant correlation was observed between obesity, BMI before and during pregnancy, HbA1c, FBS, cholesterol, and triglyceride levels among mothers with gestational diabetes compared to healthy pregnant mothers P = 0.0001. According to data analysis, there was no significant association between rs1421085 and rs9939609 of the FTO gene with gestational diabetes.
Conclusions: Considering the conflicting results between the association of FTO gene polymorphisms with gestational diabetes, to better identify and understand the pathogenesis of the disease, more studies with a higher number of samples and more racial groups are needed. In the future, identifying the profile and locations of genetic susceptibility to gestational diabetes can be used in the patient's management. |
| format | Article |
| id | doaj-art-acaa4ab325c34c7eb8ccb47b6ab7d4c3 |
| institution | OA Journals |
| issn | 1735-5338 2008-644X |
| language | fas |
| publishDate | 2024-03-01 |
| publisher | Arak Medical University |
| record_format | Article |
| series | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| spelling | doaj-art-acaa4ab325c34c7eb8ccb47b6ab7d4c32025-08-20T02:17:50ZfasArak Medical UniversityMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk1735-53382008-644X2024-03-012714652Association Study of rs1421085 and rs9939609 in FTO Gene with Gestational Diabetes in the Arak CityParnian Hekmatpou0Maryam Maryam Ghanbari1Milad Gholami2 Department of Genetics, Faculty of Biological Sciences, Tehran North Branch, Islamic Azad University, Tehran, Iran Department of Microbial Biotechnology, Faculty of Biological Sciences, Tehran North Branch, Islamic Azad University, Tehran, Iran Department of Biochemistry and Genetics, School of Medicine, Arak University of Medical Sciences, Arak, Iran Introduction: Gestational diabetes is defined as hyperglycemia with onset or first diagnosis during pregnancy, with a lower frequency than general diabetes. Overweight and obesity, old age at the time of pregnancy, previous history of gestational diabetes, family history of type 2 diabetes, and race are risk factors for gestational diabetes. Recently, the relationship between two polymorphisms (rs9939609 and rs1421085) of Fat mass and obesity-associated (FTO) gene and the risk of gestational diabetes has been investigated in some studies with conflicting results. Therefore, our aim of the present study was to investigate the association study of rs1421085 and rs9939609 of the FTO gene on gestational diabetes. Methods: In this case-control study, five cc of peripheral blood was collected from 100 cases with gestational diabetes and 116 control pregnant women from Taleghani Hospital in Arak, and then DNA was extracted. After designing the specific primers, the genotypes were determined by the Tetra ARMS-PCR method. Demographic information was compared with genotypes between the two groups were compared using SNPSTAT software. Results: A significant correlation was observed between obesity, BMI before and during pregnancy, HbA1c, FBS, cholesterol, and triglyceride levels among mothers with gestational diabetes compared to healthy pregnant mothers P = 0.0001. According to data analysis, there was no significant association between rs1421085 and rs9939609 of the FTO gene with gestational diabetes. Conclusions: Considering the conflicting results between the association of FTO gene polymorphisms with gestational diabetes, to better identify and understand the pathogenesis of the disease, more studies with a higher number of samples and more racial groups are needed. In the future, identifying the profile and locations of genetic susceptibility to gestational diabetes can be used in the patient's management.http://jams.arakmu.ac.ir/article-1-7649-en.pdfgestational diabetesftogeners9939609rs1421085 |
| spellingShingle | Parnian Hekmatpou Maryam Maryam Ghanbari Milad Gholami Association Study of rs1421085 and rs9939609 in FTO Gene with Gestational Diabetes in the Arak City Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk gestational diabetes fto gene rs9939609 rs1421085 |
| title | Association Study of rs1421085 and rs9939609 in FTO Gene with Gestational Diabetes in the Arak City |
| title_full | Association Study of rs1421085 and rs9939609 in FTO Gene with Gestational Diabetes in the Arak City |
| title_fullStr | Association Study of rs1421085 and rs9939609 in FTO Gene with Gestational Diabetes in the Arak City |
| title_full_unstemmed | Association Study of rs1421085 and rs9939609 in FTO Gene with Gestational Diabetes in the Arak City |
| title_short | Association Study of rs1421085 and rs9939609 in FTO Gene with Gestational Diabetes in the Arak City |
| title_sort | association study of rs1421085 and rs9939609 in fto gene with gestational diabetes in the arak city |
| topic | gestational diabetes fto gene rs9939609 rs1421085 |
| url | http://jams.arakmu.ac.ir/article-1-7649-en.pdf |
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