Upregulation of ferroptosis in glucocorticoids-induced posterior subcapsular cataracts

Upregulation of ferroptosis in glucocorticoids-induced posterior subcapsular cataracts

Abstract The Glucocorticoid-induced posterior subcapsular cataracts (GIC) is a common complication of patients received glucocorticoid treatment in clinic. We find that dexamethasone (DEX) induces lens epithelial cells’ ferroptosis. DEX treatment increases intracellular ferroptosis signatures in len...

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Main Authors: Yuhang Zhang, Wei Si, Yi Mao, Su Xu, Fuzhen Li, Jingjing Liu, Shanshan Du, Jingzhi Shao, Ying Qi, Xuyan Peng, Mengjiao Xue, Mingjun Jiang, Keyu Guo, Yanzhong Hu, Fengyan Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08067-y
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