Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases
Abstract We examined the risk of prostate cancer in the Korean population stratified on the basis of age group and risk based on metabolic diseases, using National Health Insurance System (NHIS) data. Of the 51,827,813 people from the NHIS data in 2015, 10,879,591 men without prostate cancer who und...
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| Format: | Article |
| Language: | English |
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Wiley
2018-06-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1462 |
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| _version_ | 1849430838054223872 |
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| author | Jin Bong Choi Jung Ho Kim Sung‐Hoo Hong Kyung‐Do Han U‐Syn Ha |
| author_facet | Jin Bong Choi Jung Ho Kim Sung‐Hoo Hong Kyung‐Do Han U‐Syn Ha |
| author_sort | Jin Bong Choi |
| collection | DOAJ |
| description | Abstract We examined the risk of prostate cancer in the Korean population stratified on the basis of age group and risk based on metabolic diseases, using National Health Insurance System (NHIS) data. Of the 51,827,813 people from the NHIS data in 2015, 10,879,591 men without prostate cancer who underwent a health examination were analyzed. The risk of prostate cancer was analyzed with stratification by age. Multivariate‐adjusted Cox regression analysis was conducted to examine the association between prostate cancer and metabolic diseases by age groups. The risk of prostate cancer increased continuously with age and 59 years may be a point of inflection. The hazard ratio (HR) of prostate cancer development rose sharply as that age point passed. The population with metabolic diseases was more likely to develop prostate cancer than the population without any of these components. In addition, the incidence rate ratio (IRR) decreased from the youngest age group to the age group comprising 55–59 year olds. Beyond this age group, there was a plateau. The relative risk for prostate cancer associated with metabolic diseases also showed divergent associations with age. The risk of prostate cancer increased continuously with age and the peak Youden index was at 59 years. The relative risk for prostate cancer according to metabolic diseases also showed divergent associations beyond 59 years of age. Therefore, setting the age threshold at 59 years would improve the present clinical risk stratification for prostate cancer in Korea. |
| format | Article |
| id | doaj-art-aca7b52ba3bb4030a64aab33bcfedf30 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-aca7b52ba3bb4030a64aab33bcfedf302025-08-20T03:27:51ZengWileyCancer Medicine2045-76342018-06-01762736274310.1002/cam4.1462Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseasesJin Bong Choi0Jung Ho Kim1Sung‐Hoo Hong2Kyung‐Do Han3U‐Syn Ha4Department of Urology Bucheon St. Mary's Hospital College of Medicine The Catholic University of Korea Bucheon KoreaDepartment of Urology Dongnam Institute of Radiological and Medical Sciences Cancer Center Busan KoreaDepartment of Urology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul KoreaDepartment of Biostatistics College of Medicine The Catholic University of Korea Seoul KoreaDepartment of Urology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul KoreaAbstract We examined the risk of prostate cancer in the Korean population stratified on the basis of age group and risk based on metabolic diseases, using National Health Insurance System (NHIS) data. Of the 51,827,813 people from the NHIS data in 2015, 10,879,591 men without prostate cancer who underwent a health examination were analyzed. The risk of prostate cancer was analyzed with stratification by age. Multivariate‐adjusted Cox regression analysis was conducted to examine the association between prostate cancer and metabolic diseases by age groups. The risk of prostate cancer increased continuously with age and 59 years may be a point of inflection. The hazard ratio (HR) of prostate cancer development rose sharply as that age point passed. The population with metabolic diseases was more likely to develop prostate cancer than the population without any of these components. In addition, the incidence rate ratio (IRR) decreased from the youngest age group to the age group comprising 55–59 year olds. Beyond this age group, there was a plateau. The relative risk for prostate cancer associated with metabolic diseases also showed divergent associations with age. The risk of prostate cancer increased continuously with age and the peak Youden index was at 59 years. The relative risk for prostate cancer according to metabolic diseases also showed divergent associations beyond 59 years of age. Therefore, setting the age threshold at 59 years would improve the present clinical risk stratification for prostate cancer in Korea.https://doi.org/10.1002/cam4.1462Agediabetes mellitusdyslipidemiashypertensionmetabolic diseasesprostate cancer |
| spellingShingle | Jin Bong Choi Jung Ho Kim Sung‐Hoo Hong Kyung‐Do Han U‐Syn Ha Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases Cancer Medicine Age diabetes mellitus dyslipidemias hypertension metabolic diseases prostate cancer |
| title | Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases |
| title_full | Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases |
| title_fullStr | Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases |
| title_full_unstemmed | Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases |
| title_short | Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases |
| title_sort | difference in prostate cancer incidence around sixty years effects of age and metabolic diseases |
| topic | Age diabetes mellitus dyslipidemias hypertension metabolic diseases prostate cancer |
| url | https://doi.org/10.1002/cam4.1462 |
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