Integration of phosphoinositide 3-kinase (PI3K) and transforming growth factor β1 (TGF-β1) signaling cascades: role in the therapeutic inefficiency of tamoxifen
Growth factors signaling cascades and their interaction with the central regulatory targets of tumor cells and estrogens are considered as the main mechanisms of hormonal resistance in breast cancer. The integration of the transforming growth factor β1 (TGF-β1) and PI3K (phosphoinositide 3-kinase)/...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2023-12-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/609 |
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| author | N. N. Babyshkina I. A. Uzyanbaev T. A. Dronova N. V. Cherdyntseva |
| author_facet | N. N. Babyshkina I. A. Uzyanbaev T. A. Dronova N. V. Cherdyntseva |
| author_sort | N. N. Babyshkina |
| collection | DOAJ |
| description | Growth factors signaling cascades and their interaction with the central regulatory targets of tumor cells and estrogens are considered as the main mechanisms of hormonal resistance in breast cancer. The integration of the transforming growth factor β1 (TGF-β1) and PI3K (phosphoinositide 3-kinase)/Akt (protein kinase B)/mTOR (mammalian target of rapamycin) signaling pathway may result in the activation of proliferation and, as a result, the development of an in-effective response to therapy and disease progression. The review summarizes a systematic analysis of the literature data on the role of TGF-β1 signaling in the mechanisms of tamoxifen resistance to in the aspect of interaction with the PI3K/Akt/mTOR. The interaction between the estrogen receptors α signaling and tamoxifen, the mechanisms of regulatory activation of TGF-β1 and PI3K/Akt/mTOR, as well as their contribution to the tamoxifen response are considered. The direct involvement of TGF-β1/PI3K in the mechanisms of tamoxifen resistance to determines the prospects for studying the effector of these cascades as molecular targets. The knowledge accumulated to date allows considering the TGF-β1/PI3K signaling pathway as a potential molecular tool for the search for effective strategies for blocking the resistance of tumor cells to tamoxifen. |
| format | Article |
| id | doaj-art-aca49df39c34435a9f71dcfe3347b71c |
| institution | Kabale University |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2023-12-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-aca49df39c34435a9f71dcfe3347b71c2025-08-20T04:00:14ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872023-12-01104476010.17650/2313-805X-2023-10-4-47-60306Integration of phosphoinositide 3-kinase (PI3K) and transforming growth factor β1 (TGF-β1) signaling cascades: role in the therapeutic inefficiency of tamoxifenN. N. Babyshkina0I. A. Uzyanbaev1T. A. Dronova2N. V. Cherdyntseva3Cancer Research Instituteof Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical UniversitySiberian State Medical UniversityCancer Research Instituteof Tomsk National Research Medical Center of the Russian Academy of SciencesCancer Research Instituteof Tomsk National Research Medical Center of the Russian Academy of SciencesGrowth factors signaling cascades and their interaction with the central regulatory targets of tumor cells and estrogens are considered as the main mechanisms of hormonal resistance in breast cancer. The integration of the transforming growth factor β1 (TGF-β1) and PI3K (phosphoinositide 3-kinase)/Akt (protein kinase B)/mTOR (mammalian target of rapamycin) signaling pathway may result in the activation of proliferation and, as a result, the development of an in-effective response to therapy and disease progression. The review summarizes a systematic analysis of the literature data on the role of TGF-β1 signaling in the mechanisms of tamoxifen resistance to in the aspect of interaction with the PI3K/Akt/mTOR. The interaction between the estrogen receptors α signaling and tamoxifen, the mechanisms of regulatory activation of TGF-β1 and PI3K/Akt/mTOR, as well as their contribution to the tamoxifen response are considered. The direct involvement of TGF-β1/PI3K in the mechanisms of tamoxifen resistance to determines the prospects for studying the effector of these cascades as molecular targets. The knowledge accumulated to date allows considering the TGF-β1/PI3K signaling pathway as a potential molecular tool for the search for effective strategies for blocking the resistance of tumor cells to tamoxifen.https://umo.abvpress.ru/jour/article/view/609transforming growth factor β1pi3k/akt/mtorbreast cancerestrogen receptorstamoxifenresistance |
| spellingShingle | N. N. Babyshkina I. A. Uzyanbaev T. A. Dronova N. V. Cherdyntseva Integration of phosphoinositide 3-kinase (PI3K) and transforming growth factor β1 (TGF-β1) signaling cascades: role in the therapeutic inefficiency of tamoxifen Успехи молекулярной онкологии transforming growth factor β1 pi3k/akt/mtor breast cancer estrogen receptors tamoxifen resistance |
| title | Integration of phosphoinositide 3-kinase (PI3K) and transforming growth factor β1 (TGF-β1) signaling cascades: role in the therapeutic inefficiency of tamoxifen |
| title_full | Integration of phosphoinositide 3-kinase (PI3K) and transforming growth factor β1 (TGF-β1) signaling cascades: role in the therapeutic inefficiency of tamoxifen |
| title_fullStr | Integration of phosphoinositide 3-kinase (PI3K) and transforming growth factor β1 (TGF-β1) signaling cascades: role in the therapeutic inefficiency of tamoxifen |
| title_full_unstemmed | Integration of phosphoinositide 3-kinase (PI3K) and transforming growth factor β1 (TGF-β1) signaling cascades: role in the therapeutic inefficiency of tamoxifen |
| title_short | Integration of phosphoinositide 3-kinase (PI3K) and transforming growth factor β1 (TGF-β1) signaling cascades: role in the therapeutic inefficiency of tamoxifen |
| title_sort | integration of phosphoinositide 3 kinase pi3k and transforming growth factor β1 tgf β1 signaling cascades role in the therapeutic inefficiency of tamoxifen |
| topic | transforming growth factor β1 pi3k/akt/mtor breast cancer estrogen receptors tamoxifen resistance |
| url | https://umo.abvpress.ru/jour/article/view/609 |
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