New N-amino-5-cyano-6-pyridones as antimicrobial small molecules endowed with DNA gyrase a inhibitory activity: design, one-pot synthesis, biological assessment and in silico insights

New N-amino-5-cyano-6-pyridones as antimicrobial small molecules endowed with DNA gyrase a inhibitory activity: design, one-pot synthesis, biological assessment and in silico insights

Abstract A set of innovative N-amino-5-cyano-6-pyridones derivatives was developed and produced using one-pot three-component procedures. The evaluated molecules were examined for their antimicrobial efficacy. Based on the acquired findings, most of the investigated compounds had promising antimicro...

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Bibliographic Details
Main Authors: Omkulthom Al Kamaly, Amel S. Younes, Marwa F. Harras, Rehab Sabour, Aisha A. Alsfouk, Mona H. Ibrahim
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Chemistry
Subjects:
One-pot synthesis
Antimicrobial
Pyridones
DNA gyrase
Online Access:https://doi.org/10.1186/s13065-024-01342-9
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