Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogs.
Noscapine, a plant-derived, non-toxic, over-the-counter antitussive alkaloid has tubulin-binding properties. Based upon the structural resemblance of noscapine to colchicine, a tubulin-binding anti-inflammatory drug, noscapine and its semi-synthetic brominated analogs were examined for in vitro anti...
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| Language: | English |
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Public Library of Science (PLoS)
2010-02-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009165&type=printable |
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| author | Susu Zughaier Prasanthi Karna David Stephens Ritu Aneja |
| author_facet | Susu Zughaier Prasanthi Karna David Stephens Ritu Aneja |
| author_sort | Susu Zughaier |
| collection | DOAJ |
| description | Noscapine, a plant-derived, non-toxic, over-the-counter antitussive alkaloid has tubulin-binding properties. Based upon the structural resemblance of noscapine to colchicine, a tubulin-binding anti-inflammatory drug, noscapine and its semi-synthetic brominated analogs were examined for in vitro anti-inflammatory activity. Brominated noscapine analogs were found to inhibit cytokine and chemokine release from macrophage cell lines but did not affect cell viability. Brominated noscapine analogs demonstrated anti-inflammatory properties in both TLR- and non-TLR induced in vitro innate immune pathway inflammation models, mimicking septic and sterile infection respectively. In addition, electron microscopy and immunoblotting data indicated that these analogs induced robust autophagy in human macrophages. This study is the first report to identify brominated noscapines as innate immune pathway anti-inflammatory molecules. |
| format | Article |
| id | doaj-art-aca0d125eae24b1abd1d1916afb3af6d |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2010-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-aca0d125eae24b1abd1d1916afb3af6d2025-08-20T03:07:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-02-0152e916510.1371/journal.pone.0009165Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogs.Susu ZughaierPrasanthi KarnaDavid StephensRitu AnejaNoscapine, a plant-derived, non-toxic, over-the-counter antitussive alkaloid has tubulin-binding properties. Based upon the structural resemblance of noscapine to colchicine, a tubulin-binding anti-inflammatory drug, noscapine and its semi-synthetic brominated analogs were examined for in vitro anti-inflammatory activity. Brominated noscapine analogs were found to inhibit cytokine and chemokine release from macrophage cell lines but did not affect cell viability. Brominated noscapine analogs demonstrated anti-inflammatory properties in both TLR- and non-TLR induced in vitro innate immune pathway inflammation models, mimicking septic and sterile infection respectively. In addition, electron microscopy and immunoblotting data indicated that these analogs induced robust autophagy in human macrophages. This study is the first report to identify brominated noscapines as innate immune pathway anti-inflammatory molecules.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009165&type=printable |
| spellingShingle | Susu Zughaier Prasanthi Karna David Stephens Ritu Aneja Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogs. PLoS ONE |
| title | Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogs. |
| title_full | Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogs. |
| title_fullStr | Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogs. |
| title_full_unstemmed | Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogs. |
| title_short | Potent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogs. |
| title_sort | potent anti inflammatory activity of novel microtubule modulating brominated noscapine analogs |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009165&type=printable |
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