The role of geography in human adaptation.
Various observations argue for a role of adaptation in recent human evolution, including results from genome-wide studies and analyses of selection signals at candidate genes. Here, we use genome-wide SNP data from the HapMap and CEPH-Human Genome Diversity Panel samples to study the geographic dist...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2009-06-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000500&type=printable |
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| _version_ | 1850183393304641536 |
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| author | Graham Coop Joseph K Pickrell John Novembre Sridhar Kudaravalli Jun Li Devin Absher Richard M Myers Luigi Luca Cavalli-Sforza Marcus W Feldman Jonathan K Pritchard |
| author_facet | Graham Coop Joseph K Pickrell John Novembre Sridhar Kudaravalli Jun Li Devin Absher Richard M Myers Luigi Luca Cavalli-Sforza Marcus W Feldman Jonathan K Pritchard |
| author_sort | Graham Coop |
| collection | DOAJ |
| description | Various observations argue for a role of adaptation in recent human evolution, including results from genome-wide studies and analyses of selection signals at candidate genes. Here, we use genome-wide SNP data from the HapMap and CEPH-Human Genome Diversity Panel samples to study the geographic distributions of putatively selected alleles at a range of geographic scales. We find that the average allele frequency divergence is highly predictive of the most extreme F(ST) values across the whole genome. On a broad scale, the geographic distribution of putatively selected alleles almost invariably conforms to population clusters identified using randomly chosen genetic markers. Given this structure, there are surprisingly few fixed or nearly fixed differences between human populations. Among the nearly fixed differences that do exist, nearly all are due to fixation events that occurred outside of Africa, and most appear in East Asia. These patterns suggest that selection is often weak enough that neutral processes -- especially population history, migration, and drift -- exert powerful influences over the fate and geographic distribution of selected alleles. |
| format | Article |
| id | doaj-art-ac9f30ac2bf845da9b3a73d08406237b |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2009-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-ac9f30ac2bf845da9b3a73d08406237b2025-08-20T02:17:24ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042009-06-0156e100050010.1371/journal.pgen.1000500The role of geography in human adaptation.Graham CoopJoseph K PickrellJohn NovembreSridhar KudaravalliJun LiDevin AbsherRichard M MyersLuigi Luca Cavalli-SforzaMarcus W FeldmanJonathan K PritchardVarious observations argue for a role of adaptation in recent human evolution, including results from genome-wide studies and analyses of selection signals at candidate genes. Here, we use genome-wide SNP data from the HapMap and CEPH-Human Genome Diversity Panel samples to study the geographic distributions of putatively selected alleles at a range of geographic scales. We find that the average allele frequency divergence is highly predictive of the most extreme F(ST) values across the whole genome. On a broad scale, the geographic distribution of putatively selected alleles almost invariably conforms to population clusters identified using randomly chosen genetic markers. Given this structure, there are surprisingly few fixed or nearly fixed differences between human populations. Among the nearly fixed differences that do exist, nearly all are due to fixation events that occurred outside of Africa, and most appear in East Asia. These patterns suggest that selection is often weak enough that neutral processes -- especially population history, migration, and drift -- exert powerful influences over the fate and geographic distribution of selected alleles.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000500&type=printable |
| spellingShingle | Graham Coop Joseph K Pickrell John Novembre Sridhar Kudaravalli Jun Li Devin Absher Richard M Myers Luigi Luca Cavalli-Sforza Marcus W Feldman Jonathan K Pritchard The role of geography in human adaptation. PLoS Genetics |
| title | The role of geography in human adaptation. |
| title_full | The role of geography in human adaptation. |
| title_fullStr | The role of geography in human adaptation. |
| title_full_unstemmed | The role of geography in human adaptation. |
| title_short | The role of geography in human adaptation. |
| title_sort | role of geography in human adaptation |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000500&type=printable |
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