A Clinical-Epidemiological Study on Beta-Blocker Poisonings Based on the Type of Drug Overdose
Background. Beta‐blockers carry a high risk of potentially causing fatal poisoning if overdosed. We aimed to assess the clinical and epidemiological characteristics of patients with beta-blocker poisoning. Methods. Patients were categorized based on the type of drug poisoning into propranolol, other...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2023/1064955 |
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| author | Nastaran Eizadi-Mood Mahtab Adib Arman Otroshi Gholamali Dorooshi Rokhsareh Meamar |
| author_facet | Nastaran Eizadi-Mood Mahtab Adib Arman Otroshi Gholamali Dorooshi Rokhsareh Meamar |
| author_sort | Nastaran Eizadi-Mood |
| collection | DOAJ |
| description | Background. Beta‐blockers carry a high risk of potentially causing fatal poisoning if overdosed. We aimed to assess the clinical and epidemiological characteristics of patients with beta-blocker poisoning. Methods. Patients were categorized based on the type of drug poisoning into propranolol, other beta-blockers, and the combination of beta-blocker groups, respectively. Demographic data, drug toxicity, and clinical, laboratory, and treatment information of different groups were compared. Results. During the study period, 5086 poisoned patients were hospitalized, of whom 255 (5.1%) had beta-blocker poisoning. Most patients were women (80.8%), married (50.6%), with a history of psychiatric disorders (36.5%), previous suicide attempts (34.6%), and intentional type of exposure (95.3%). The mean ± SD age of the patients was 28.94 ± 11.08 years. Propranolol toxicity was the most common among different beta-blockers (84.4%). There was a significant difference in age, occupation, education level, and history of psychiatric diseases with respect to the type of beta-blocker poisoning (P<0.05). We observed changes in the consciousness level and need for endotracheal intubation only in the third group (combination of beta-blockers). Only 1 (0.4%) patient had a fatal outcome in toxicity with the combination of beta-blockers. Conclusion. Beta-blocker poisoning is not common in our poisoning referral center. Propranolol toxicity was most common among different beta-blockers. Although symptoms are not different among defined beta‐blocker groups, more severe symptoms are observed in the combination of the beta-blocker group. Only one patient had a fatal outcome in the toxicity with the combination of the beta-blocker group. Therefore, poisoning circumstances have to investigate thoroughly to screen coexposure with combined drugs. |
| format | Article |
| id | doaj-art-ac9bb009e91a4248a0f3977388cc4f4e |
| institution | OA Journals |
| issn | 1687-8205 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-ac9bb009e91a4248a0f3977388cc4f4e2025-08-20T02:20:22ZengWileyJournal of Toxicology1687-82052023-01-01202310.1155/2023/1064955A Clinical-Epidemiological Study on Beta-Blocker Poisonings Based on the Type of Drug OverdoseNastaran Eizadi-Mood0Mahtab Adib1Arman Otroshi2Gholamali Dorooshi3Rokhsareh Meamar4Isfahan Clinical Toxicology Research CenterIsfahan Clinical Toxicology Research CenterIsfahan Clinical Toxicology Research CenterIsfahan Clinical Toxicology Research CenterIsfahan Clinical Toxicology Research CenterBackground. Beta‐blockers carry a high risk of potentially causing fatal poisoning if overdosed. We aimed to assess the clinical and epidemiological characteristics of patients with beta-blocker poisoning. Methods. Patients were categorized based on the type of drug poisoning into propranolol, other beta-blockers, and the combination of beta-blocker groups, respectively. Demographic data, drug toxicity, and clinical, laboratory, and treatment information of different groups were compared. Results. During the study period, 5086 poisoned patients were hospitalized, of whom 255 (5.1%) had beta-blocker poisoning. Most patients were women (80.8%), married (50.6%), with a history of psychiatric disorders (36.5%), previous suicide attempts (34.6%), and intentional type of exposure (95.3%). The mean ± SD age of the patients was 28.94 ± 11.08 years. Propranolol toxicity was the most common among different beta-blockers (84.4%). There was a significant difference in age, occupation, education level, and history of psychiatric diseases with respect to the type of beta-blocker poisoning (P<0.05). We observed changes in the consciousness level and need for endotracheal intubation only in the third group (combination of beta-blockers). Only 1 (0.4%) patient had a fatal outcome in toxicity with the combination of beta-blockers. Conclusion. Beta-blocker poisoning is not common in our poisoning referral center. Propranolol toxicity was most common among different beta-blockers. Although symptoms are not different among defined beta‐blocker groups, more severe symptoms are observed in the combination of the beta-blocker group. Only one patient had a fatal outcome in the toxicity with the combination of the beta-blocker group. Therefore, poisoning circumstances have to investigate thoroughly to screen coexposure with combined drugs.http://dx.doi.org/10.1155/2023/1064955 |
| spellingShingle | Nastaran Eizadi-Mood Mahtab Adib Arman Otroshi Gholamali Dorooshi Rokhsareh Meamar A Clinical-Epidemiological Study on Beta-Blocker Poisonings Based on the Type of Drug Overdose Journal of Toxicology |
| title | A Clinical-Epidemiological Study on Beta-Blocker Poisonings Based on the Type of Drug Overdose |
| title_full | A Clinical-Epidemiological Study on Beta-Blocker Poisonings Based on the Type of Drug Overdose |
| title_fullStr | A Clinical-Epidemiological Study on Beta-Blocker Poisonings Based on the Type of Drug Overdose |
| title_full_unstemmed | A Clinical-Epidemiological Study on Beta-Blocker Poisonings Based on the Type of Drug Overdose |
| title_short | A Clinical-Epidemiological Study on Beta-Blocker Poisonings Based on the Type of Drug Overdose |
| title_sort | clinical epidemiological study on beta blocker poisonings based on the type of drug overdose |
| url | http://dx.doi.org/10.1155/2023/1064955 |
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