Steroid induced ocular complications in idiopathic nephrotic syndrome: a cross sectional single center study
Objective: To screen children receiving steroids to identify ocular complications and their prevalence. Method: The cross-sectional study was conducted at the Paediatric Nephrology and Ophthalmology departments of the Sindh Institute of Urology and Transplantation, Karachi, from May to October 20...
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Pakistan Medical Association
2024-01-01
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| Series: | Journal of the Pakistan Medical Association |
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| Online Access: | https://jpma.org.pk/index.php/public_html/article/view/10573 |
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| author | Zunaira Zulfiqar Fatema Lanewala Sabeeta Khatri Irshad Bajeer Madiha Aziz Seema Hashmi |
| author_facet | Zunaira Zulfiqar Fatema Lanewala Sabeeta Khatri Irshad Bajeer Madiha Aziz Seema Hashmi |
| author_sort | Zunaira Zulfiqar |
| collection | DOAJ |
| description |
Objective: To screen children receiving steroids to identify ocular complications and their prevalence.
Method: The cross-sectional study was conducted at the Paediatric Nephrology and Ophthalmology departments of the Sindh Institute of Urology and Transplantation, Karachi, from May to October 2022, and comprised patients who received at least 1500mg cumulative steroid dose for a minimum of 3 months. They were screened for steroid-sensitive or steroid-resistant nephrotic syndrome. Ocular examinations, including visual acuity, intraocular pressure, slit-lamp biomicroscopy, lens examination and fundus evaluation, were performed. Data was analysed using SPSS 22.
Results: Of the 124 subjects with mean age 8.15±2.03 years (range: 6-12 years), 64(51.6%) were boys. Steroid-sensitive nephrotic syndrome was present in 97(78%) cases. The mean cumulative steroid dose was 3999.31±1564.22mg. Overall, 36(29%) children developed ocular complications. Blood pressure, number of relapses and the duration of treatment were significantly associated (p<0.05).
Conclusion: Refractive errors were the most frequent side effects/complication seen among children with nephrotic syndrome who received prolonged corticosteroids.
Key Words: Nephrotic syndrome, Corticosteroids, Cataract, Glaucoma, Refractive error.
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| format | Article |
| id | doaj-art-ac9aef13020948418b57c8fef3d5aae2 |
| institution | DOAJ |
| issn | 0030-9982 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj-art-ac9aef13020948418b57c8fef3d5aae22025-08-20T02:56:01ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822024-01-0174210.47391/JPMA.10573Steroid induced ocular complications in idiopathic nephrotic syndrome: a cross sectional single center studyZunaira Zulfiqar0Fatema Lanewala1Sabeeta Khatri2Irshad Bajeer3Madiha Aziz4Seema Hashmi5Department of Paediatric Nephrology, Sindh Institute of Urology and Transplantation, Karachi, PakistanDepartment of Ophthalmology, Sindh Institute of Urology and Transplantation, Karachi, PakistanDepartment of Paediatric Nephrology, Sindh Institute of Urology and Transplantation, Karachi, PakistanDepartment of Paediatric Nephrology, Sindh Institute of Urology and Transplantation, Karachi, PakistanDepartment of Paediatric Nephrology, Sindh Institute of Urology and Transplantation, Karachi, PakistanDepartment of Paediatric Nephrology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan Objective: To screen children receiving steroids to identify ocular complications and their prevalence. Method: The cross-sectional study was conducted at the Paediatric Nephrology and Ophthalmology departments of the Sindh Institute of Urology and Transplantation, Karachi, from May to October 2022, and comprised patients who received at least 1500mg cumulative steroid dose for a minimum of 3 months. They were screened for steroid-sensitive or steroid-resistant nephrotic syndrome. Ocular examinations, including visual acuity, intraocular pressure, slit-lamp biomicroscopy, lens examination and fundus evaluation, were performed. Data was analysed using SPSS 22. Results: Of the 124 subjects with mean age 8.15±2.03 years (range: 6-12 years), 64(51.6%) were boys. Steroid-sensitive nephrotic syndrome was present in 97(78%) cases. The mean cumulative steroid dose was 3999.31±1564.22mg. Overall, 36(29%) children developed ocular complications. Blood pressure, number of relapses and the duration of treatment were significantly associated (p<0.05). Conclusion: Refractive errors were the most frequent side effects/complication seen among children with nephrotic syndrome who received prolonged corticosteroids. Key Words: Nephrotic syndrome, Corticosteroids, Cataract, Glaucoma, Refractive error. https://jpma.org.pk/index.php/public_html/article/view/10573Nephrotic syndromecorticosteroidscataractGlaucomarefrective error |
| spellingShingle | Zunaira Zulfiqar Fatema Lanewala Sabeeta Khatri Irshad Bajeer Madiha Aziz Seema Hashmi Steroid induced ocular complications in idiopathic nephrotic syndrome: a cross sectional single center study Journal of the Pakistan Medical Association Nephrotic syndrome corticosteroids cataract Glaucoma refrective error |
| title | Steroid induced ocular complications in idiopathic nephrotic syndrome: a cross sectional single center study |
| title_full | Steroid induced ocular complications in idiopathic nephrotic syndrome: a cross sectional single center study |
| title_fullStr | Steroid induced ocular complications in idiopathic nephrotic syndrome: a cross sectional single center study |
| title_full_unstemmed | Steroid induced ocular complications in idiopathic nephrotic syndrome: a cross sectional single center study |
| title_short | Steroid induced ocular complications in idiopathic nephrotic syndrome: a cross sectional single center study |
| title_sort | steroid induced ocular complications in idiopathic nephrotic syndrome a cross sectional single center study |
| topic | Nephrotic syndrome corticosteroids cataract Glaucoma refrective error |
| url | https://jpma.org.pk/index.php/public_html/article/view/10573 |
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