Olaparib monotherapy or combination therapy in lung cancer: an updated systematic review and meta- analysis

Olaparib monotherapy or combination therapy in lung cancer: an updated systematic review and meta- analysis

Background and aimsImpaired double strand DNA repair by homologous repair deficiency (HRD) leads to sensitivity to poly ADP ribose polymerase (PARP) inhibition. A subset of non-small cell lung cancers (NSCLCs) harbour impaired DNA double strand break repair. This study aims to investigate meta-analy...

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Main Authors: Sajjad Hajihosseini, Ehsan Emami, Seyed Amirali Zakavi, Parnia Jochin, Mehregan Shahrokhi, Sahar Khoshravesh, Mitra Goli, Mohaddeseh Belbasi, Gisou Erabi, Niloofar Deravi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
Subjects:
olaparib
lung cancer
NSCLCs
gefitinib
durvalumab
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1505889/full
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