Dissecting the dual role of OTU family proteins in tumor progression and immune escape

Dissecting the dual role of OTU family proteins in tumor progression and immune escape

As a core mechanism regulating intracellular protein homeostasis, the dynamic equilibrium between ubiquitination and deubiquitination profoundly impacts the functionality and fate of target proteins. The Ovarian tumor domain (OTU) family, a vital subclass of deubiquitinating enzymes, comprises 16 me...

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Bibliographic Details
Main Authors: Xiaolong Tang, Yadan Li, Yongshuo Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
OTU family
deubiquitinating enzymes
tumorigenesis
immune regulation
ubiquitination-deubiquitination balance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1544341/full
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