SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODEL
It was examined a new method for correction of hepatic failure by transplantation of liver support biounit (liver cells, immobilized on biocompatible and biodegradable 3D-matrixes ElastoPOB®) into small intestine mesentery. It was determined that after modeling of acute hepatic failure on dogs by 65...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2011-06-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/417 |
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| author | M. Y. Shagidulin N. A. Onishchenko M. E. Krasheninnikov I. M. Iljinsky N. P. Mogeiko N. P. Shmerko A. A. Andriyanova P. V. Avramov E. A. Nemets V. I. Sevastjanov S. V. Gautier |
| author_facet | M. Y. Shagidulin N. A. Onishchenko M. E. Krasheninnikov I. M. Iljinsky N. P. Mogeiko N. P. Shmerko A. A. Andriyanova P. V. Avramov E. A. Nemets V. I. Sevastjanov S. V. Gautier |
| author_sort | M. Y. Shagidulin |
| collection | DOAJ |
| description | It was examined a new method for correction of hepatic failure by transplantation of liver support biounit (liver cells, immobilized on biocompatible and biodegradable 3D-matrixes ElastoPOB®) into small intestine mesentery. It was determined that after modeling of acute hepatic failure on dogs by 65–70% liver resection) and transplantation liver support biounit the restoration of disturbed biochemical indecies (such as total protein, lactate, cytolytic ensymes-ALT, AST, ALP, LDH, fibrinogen, protrombine index and others) took place more rapidly on 9–14th day instead of 18th day in control. It was made a preposition about efficiency of the suggested method for correction both acute hepatic failure because even 90 days after transplantation of liver support biounit alive hepatocytes and neogenic plethoric vessels, growing through matrix were revealed. |
| format | Article |
| id | doaj-art-ac8fc5f74582469b929dd2562e8db3c0 |
| institution | Kabale University |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2011-06-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-ac8fc5f74582469b929dd2562e8db3c02025-08-20T03:59:53ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912011-06-01133596610.15825/1995-1191-2011-3-59-66360SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODELM. Y. Shagidulin0N. A. Onishchenko1M. E. Krasheninnikov2I. M. Iljinsky3N. P. Mogeiko4N. P. Shmerko5A. A. Andriyanova6P. V. Avramov7E. A. Nemets8V. I. Sevastjanov9S. V. Gautier10Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, MoscowIt was examined a new method for correction of hepatic failure by transplantation of liver support biounit (liver cells, immobilized on biocompatible and biodegradable 3D-matrixes ElastoPOB®) into small intestine mesentery. It was determined that after modeling of acute hepatic failure on dogs by 65–70% liver resection) and transplantation liver support biounit the restoration of disturbed biochemical indecies (such as total protein, lactate, cytolytic ensymes-ALT, AST, ALP, LDH, fibrinogen, protrombine index and others) took place more rapidly on 9–14th day instead of 18th day in control. It was made a preposition about efficiency of the suggested method for correction both acute hepatic failure because even 90 days after transplantation of liver support biounit alive hepatocytes and neogenic plethoric vessels, growing through matrix were revealed.https://journal.transpl.ru/vtio/article/view/417hepatic failureimmobilized hepatocytesliver support unit. |
| spellingShingle | M. Y. Shagidulin N. A. Onishchenko M. E. Krasheninnikov I. M. Iljinsky N. P. Mogeiko N. P. Shmerko A. A. Andriyanova P. V. Avramov E. A. Nemets V. I. Sevastjanov S. V. Gautier SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODEL Вестник трансплантологии и искусственных органов hepatic failure immobilized hepatocytes liver support unit. |
| title | SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODEL |
| title_full | SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODEL |
| title_fullStr | SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODEL |
| title_full_unstemmed | SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODEL |
| title_short | SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODEL |
| title_sort | survival of liver cells immobilized on 3d matrixes in liver failure model |
| topic | hepatic failure immobilized hepatocytes liver support unit. |
| url | https://journal.transpl.ru/vtio/article/view/417 |
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