ALDOC and PGK1 coordinately induce glucose metabolism reprogramming and promote development of colorectal cancer

ALDOC and PGK1 coordinately induce glucose metabolism reprogramming and promote development of colorectal cancer

Abstract Colorectal cancer (CRC) remains a significant health challenge globally, demanding a comprehensive understanding of its molecular underpinnings for effective management. In this study, we investigated the role of Aldolase C (ALDOC), a glycolytic enzyme, in CRC pathogenesis. Transcriptomic a...

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Bibliographic Details
Main Authors: Liyong Huang, Yixin Tong, Xu Li, Wei Wang, Zhen Wang, Bingchen Chen, Jifu E., Ruzhen Zhou, Hantao Wang, Jinghu He
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
Colorectal cancer
ALDOC
PGK1
Glycolysis
Molecular mechanism
Online Access:https://doi.org/10.1186/s10020-025-01252-z
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