Assessing the influence of matcha green tea extract on NF-κB/MAPK signaling pathway activation in rats: A study on irradiation-induced acute hepatic inflammatory response
Background: Numerous forms of cancer are frequently treated with radiation therapy, which provides substantial benefits in tumor control. However, adverse effects, particularly the development of severe hepatitis, may render radiation therapy ineffective. Purpose: This study investigates the potenti...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266703132500003X |
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| author | Noha Sayed Hamed Eithar K. El Adham Amal I. Hassan |
| author_facet | Noha Sayed Hamed Eithar K. El Adham Amal I. Hassan |
| author_sort | Noha Sayed Hamed |
| collection | DOAJ |
| description | Background: Numerous forms of cancer are frequently treated with radiation therapy, which provides substantial benefits in tumor control. However, adverse effects, particularly the development of severe hepatitis, may render radiation therapy ineffective. Purpose: This study investigates the potential of matcha (M) green tea extract, a natural compound known for its high antioxidant properties and health-promoting properties, in a new approach to reduce radiation-induced liver damage. Study design and method: In this experimental investigation, the administration of M was conducted on female Wistar rats for duration of two weeks after gamma-ray irradiation. Next, a series of biochemical experiments were conducted to examine the impact of M on lipid peroxidation levels, antioxidant enzyme activities, and pro-inflammatory cytokines (IL-6, IL-10, and TNF-α) in liver tissue. The Western blot method was employed for this analysis. Liver miR-122 expression levels were determined using real-time reverse transcription polymerase chain reaction. In addition, the present study investigated the mechanism by which M stops the inflammatory process's crucial NF-κB/MAPK signaling. Results: This study suggests that the NF-κB/MAPK signaling pathway that triggers the radiation-induced inflammatory response is further inhibited by M making radiation therapy effective and safe. Conclusion: Further research in this area may reveal the underlying mechanisms and pave the way for the development of novel therapies for radiation therapy patients. |
| format | Article |
| id | doaj-art-ac8b7dc4c5ca4ce38faf2a1712af05e2 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-ac8b7dc4c5ca4ce38faf2a1712af05e22025-02-10T04:35:20ZengElsevierPhytomedicine Plus2667-03132025-02-0151100730Assessing the influence of matcha green tea extract on NF-κB/MAPK signaling pathway activation in rats: A study on irradiation-induced acute hepatic inflammatory responseNoha Sayed Hamed0Eithar K. El Adham1Amal I. Hassan2Corresponding author at: Radioisotopes Department, Nuclear Research Centre, Egyptian Atomic Energy Authority (EAEA), Cairo 11787, Egypt; Radioisotopes Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo 11787, EgyptRadioisotopes Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo 11787, EgyptRadioisotopes Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo 11787, EgyptBackground: Numerous forms of cancer are frequently treated with radiation therapy, which provides substantial benefits in tumor control. However, adverse effects, particularly the development of severe hepatitis, may render radiation therapy ineffective. Purpose: This study investigates the potential of matcha (M) green tea extract, a natural compound known for its high antioxidant properties and health-promoting properties, in a new approach to reduce radiation-induced liver damage. Study design and method: In this experimental investigation, the administration of M was conducted on female Wistar rats for duration of two weeks after gamma-ray irradiation. Next, a series of biochemical experiments were conducted to examine the impact of M on lipid peroxidation levels, antioxidant enzyme activities, and pro-inflammatory cytokines (IL-6, IL-10, and TNF-α) in liver tissue. The Western blot method was employed for this analysis. Liver miR-122 expression levels were determined using real-time reverse transcription polymerase chain reaction. In addition, the present study investigated the mechanism by which M stops the inflammatory process's crucial NF-κB/MAPK signaling. Results: This study suggests that the NF-κB/MAPK signaling pathway that triggers the radiation-induced inflammatory response is further inhibited by M making radiation therapy effective and safe. Conclusion: Further research in this area may reveal the underlying mechanisms and pave the way for the development of novel therapies for radiation therapy patients.http://www.sciencedirect.com/science/article/pii/S266703132500003XMatcha extractradiation therapyhepatic inflammationNF-κB/MAPKantioxidant |
| spellingShingle | Noha Sayed Hamed Eithar K. El Adham Amal I. Hassan Assessing the influence of matcha green tea extract on NF-κB/MAPK signaling pathway activation in rats: A study on irradiation-induced acute hepatic inflammatory response Phytomedicine Plus Matcha extract radiation therapy hepatic inflammation NF-κB/MAPK antioxidant |
| title | Assessing the influence of matcha green tea extract on NF-κB/MAPK signaling pathway activation in rats: A study on irradiation-induced acute hepatic inflammatory response |
| title_full | Assessing the influence of matcha green tea extract on NF-κB/MAPK signaling pathway activation in rats: A study on irradiation-induced acute hepatic inflammatory response |
| title_fullStr | Assessing the influence of matcha green tea extract on NF-κB/MAPK signaling pathway activation in rats: A study on irradiation-induced acute hepatic inflammatory response |
| title_full_unstemmed | Assessing the influence of matcha green tea extract on NF-κB/MAPK signaling pathway activation in rats: A study on irradiation-induced acute hepatic inflammatory response |
| title_short | Assessing the influence of matcha green tea extract on NF-κB/MAPK signaling pathway activation in rats: A study on irradiation-induced acute hepatic inflammatory response |
| title_sort | assessing the influence of matcha green tea extract on nf κb mapk signaling pathway activation in rats a study on irradiation induced acute hepatic inflammatory response |
| topic | Matcha extract radiation therapy hepatic inflammation NF-κB/MAPK antioxidant |
| url | http://www.sciencedirect.com/science/article/pii/S266703132500003X |
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