The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing

The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing

Summary: Protein arginine methyltransferase 5 (PRMT5) is a promising cancer target, yet it is unclear which PRMT5 roles underlie this vulnerability. Here, we establish that PRMT5 inhibition induces a special class of unspliced introns, called detained introns (DIs). We used the depletion of CLNS1A,...

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Bibliographic Details
Main Authors: Colin E. Fowler, Natalie A. O’Hearn, Griffin J. Salus, Arundeep Singh, Paul L. Boutz, Jacqueline A. Lees
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Gene network
Genomic analysis
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422501226X
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