Iptacopan Reduces Proteinuria and Stabilizes Kidney Function in C3 Glomerulopathy

Iptacopan Reduces Proteinuria and Stabilizes Kidney Function in C3 Glomerulopathy

Introduction: C3 glomerulopathy (C3G) is a complex, chronic, ultra rare, progressive primary glomerulonephritis, resulting from alternative complement pathway overactivation, leading to kidney failure in most patients, and frequent recurrence in transplants. Iptacopan (LNP023) is an oral, proximal c...

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Main Authors: Carla M. Nester, Ute Eisenberger, Alexandre Karras, Moglie le Quintrec, Liz Lightstone, Manuel Praga, Giuseppe Remuzzi, Maria José Soler, Junhao Liu, Matthias Meier, Ronda Tawfik, Guido Junge, Andrea Biondani, Angelo J. Trapani, Nicholas J.A. Webb, Edwin K.S. Wong
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Kidney International Reports
Subjects:
C3 glomerulopathy
C3G
complement pathway
iptacopan
kidney
transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024924019892
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