Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis
Breast cancer is a cancer with global prevalence and a surge in the number of cases with each passing year. With the advancement in science and technology, significant progress has been achieved in the prevention and treatment of breast cancer to make ends meet. The scientific intradisciplinary subj...
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2024-12-01
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| author | Rasanpreet Kaur Saurabh Gupta Sunanda Kulshrestha Vishal Khandelwal Swadha Pandey Anil Kumar Gaurav Sharma Umesh Kumar Deepak Parashar Kaushik Das |
| author_facet | Rasanpreet Kaur Saurabh Gupta Sunanda Kulshrestha Vishal Khandelwal Swadha Pandey Anil Kumar Gaurav Sharma Umesh Kumar Deepak Parashar Kaushik Das |
| author_sort | Rasanpreet Kaur |
| collection | DOAJ |
| description | Breast cancer is a cancer with global prevalence and a surge in the number of cases with each passing year. With the advancement in science and technology, significant progress has been achieved in the prevention and treatment of breast cancer to make ends meet. The scientific intradisciplinary subject of “metabolomics” examines every metabolite found in a cell, tissue, system, or organism from different sources of samples. In the case of breast cancer, little is known about the regulatory pathways that could be resolved through metabolic reprogramming. Evidence related to the significant changes taking place during the onset and prognosis of breast cancer can be obtained using metabolomics. Innovative metabolomics approaches identify metabolites that lead to the discovery of biomarkers for breast cancer therapy, diagnosis, and early detection. The use of diverse analytical methods and instruments for metabolomics includes Magnetic Resonance Spectroscopy, LC/MS, UPLC/MS, etc., which, along with their high-throughput analysis, give insights into the metabolites and the molecular pathways involved. For instance, metabolome research has led to the discovery of the glutamate-to-glutamate ratio and aerobic glycolysis as biomarkers in breast cancer. The present review comprehends the updates in metabolomic research and its processes that contribute to breast cancer prognosis and metastasis. The metabolome holds a future, and this review is an attempt to amalgamate the present relevant literature that might yield crucial insights for creating innovative therapeutic strategies aimed at addressing metastatic breast cancer. |
| format | Article |
| id | doaj-art-ac7687d709fd440eb092d5c0c759340d |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-ac7687d709fd440eb092d5c0c759340d2025-01-10T13:16:13ZengMDPI AGCells2073-44092024-12-01141510.3390/cells14010005Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and DiagnosisRasanpreet Kaur0Saurabh Gupta1Sunanda Kulshrestha2Vishal Khandelwal3Swadha Pandey4Anil Kumar5Gaurav Sharma6Umesh Kumar7Deepak Parashar8Kaushik Das9Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, Mathura 281406, Uttar Pradesh, IndiaDepartment of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, Mathura 281406, Uttar Pradesh, IndiaDepartment of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, Mathura 281406, Uttar Pradesh, IndiaDepartment of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, Mathura 281406, Uttar Pradesh, IndiaDepartment of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, Mathura 281406, Uttar Pradesh, IndiaNational Institute of Immunology, New Delhi 110067, IndiaCardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Biosciences, Institute of Management Studies Ghaziabad (University Courses Campus), Ghaziabad 201015, Uttar Pradesh, IndiaDivision of Hematology & Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USABiotechnology Research and Innovation Council-National Institute of Biomedical Genomics, Kalyani 741251, West Bengal, IndiaBreast cancer is a cancer with global prevalence and a surge in the number of cases with each passing year. With the advancement in science and technology, significant progress has been achieved in the prevention and treatment of breast cancer to make ends meet. The scientific intradisciplinary subject of “metabolomics” examines every metabolite found in a cell, tissue, system, or organism from different sources of samples. In the case of breast cancer, little is known about the regulatory pathways that could be resolved through metabolic reprogramming. Evidence related to the significant changes taking place during the onset and prognosis of breast cancer can be obtained using metabolomics. Innovative metabolomics approaches identify metabolites that lead to the discovery of biomarkers for breast cancer therapy, diagnosis, and early detection. The use of diverse analytical methods and instruments for metabolomics includes Magnetic Resonance Spectroscopy, LC/MS, UPLC/MS, etc., which, along with their high-throughput analysis, give insights into the metabolites and the molecular pathways involved. For instance, metabolome research has led to the discovery of the glutamate-to-glutamate ratio and aerobic glycolysis as biomarkers in breast cancer. The present review comprehends the updates in metabolomic research and its processes that contribute to breast cancer prognosis and metastasis. The metabolome holds a future, and this review is an attempt to amalgamate the present relevant literature that might yield crucial insights for creating innovative therapeutic strategies aimed at addressing metastatic breast cancer.https://www.mdpi.com/2073-4409/14/1/5metabolomicsbreast cancertherapeuticsbiomarkersmetastasis |
| spellingShingle | Rasanpreet Kaur Saurabh Gupta Sunanda Kulshrestha Vishal Khandelwal Swadha Pandey Anil Kumar Gaurav Sharma Umesh Kumar Deepak Parashar Kaushik Das Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis Cells metabolomics breast cancer therapeutics biomarkers metastasis |
| title | Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis |
| title_full | Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis |
| title_fullStr | Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis |
| title_full_unstemmed | Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis |
| title_short | Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis |
| title_sort | metabolomics driven biomarker discovery for breast cancer prognosis and diagnosis |
| topic | metabolomics breast cancer therapeutics biomarkers metastasis |
| url | https://www.mdpi.com/2073-4409/14/1/5 |
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