Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis
Objective: This study aims to employ Mendelian Randomization (MR) analysis to investigate causal relationships between serum metabolites and CRS, identifying key pathogenic and protective factors and analyzing their mechanisms of action. Methods: Utilizing data from the Genome-Wide Association Studi...
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Elsevier
2025-07-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1808869425000692 |
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| author | Fan Jiang Junhao Tu Wenqi Luo Yizhen Jia Qing Luo Jing Ye |
| author_facet | Fan Jiang Junhao Tu Wenqi Luo Yizhen Jia Qing Luo Jing Ye |
| author_sort | Fan Jiang |
| collection | DOAJ |
| description | Objective: This study aims to employ Mendelian Randomization (MR) analysis to investigate causal relationships between serum metabolites and CRS, identifying key pathogenic and protective factors and analyzing their mechanisms of action. Methods: Utilizing data from the Genome-Wide Association Studies (GWAS) database, employing two-sample MR analysis to investigate the potential causal relationship between 233 circulating metabolites with the occurrence of CRS. Inverse Variance Weighted (IVW) model, MR-Egger method, Weighted Median, and Weighted model were employed. Sensitivity analyses were conducted with Bonferroni correction. This research aims to elucidate the impact of metabolites on the development and progression of CRS, providing valuable insights into the underlying mechanisms. Results: Following MR analysis, two metabolites were significantly associated with CRS: Tyrosine (OR = 1.223; 95% CI 1.115–1.341; p = 1.96E-05) and Creatinine (OR = 1.208; 95% CI 1.103–1.322; p = 4.11E-05). These two key risk factors may be further studied for their pathogenesis and could be targeted for modulation in the treatment of CRS. However, there are several protective factors also worth exploring, among which the correlation is more significant: Ratio of conjugated linoleic acid to total fatty acids (OR = 0.809; 95% CI 0.708‒0.923; p = 1.73E-03), Albumin (OR = 0.787; 95% CI 0.670‒0.926; p = 3.76E-03),Conjugated linoleic acid (OR = 0.664; 95% CI 0.491‒0.898; p = 7.85E-03), Diacylglycerol (OR = 0.804; 95% CI 0.654‒0.989; p = 3.87E-02), Apolipoprotein A–I (OR = 0.915; 95% CI 0.845‒0.991; p = 2.89E-02). Conclusion: In our MR study, we discovered 28 circulating metabolites linked to CRS. Importantly, tyrosine and creatinine were identified as the most significant contributors to the pathogenesis of CRS, highlighting their potential as therapeutic targets. Additionally, several protective factors may offer new avenues for preventive strategies and therapeutic interventions. These findings underscore the clinical relevance of targeting these metabolites to modulate CRS progression and improve patient outcomes. Level of evidence: Level 2*.1 |
| format | Article |
| id | doaj-art-ac757de92f75427ea354efbddd6760c4 |
| institution | DOAJ |
| issn | 1808-8694 |
| language | English |
| publishDate | 2025-07-01 |
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| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj-art-ac757de92f75427ea354efbddd6760c42025-08-20T02:45:50ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942025-07-0191410162610.1016/j.bjorl.2025.101626Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysisFan Jiang0Junhao Tu1Wenqi Luo2Yizhen Jia3Qing Luo4Jing Ye5Nanchang University, Jiangxi Medical College, The First Affiliated Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Nanchang, Jiangxi Province, ChinaNanchang University, Jiangxi Medical College, The First Affiliated Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Nanchang, Jiangxi Province, ChinaNanchang University, Jiangxi Medical College, The First Affiliated Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Nanchang, Jiangxi Province, ChinaNanchang University, Jiangxi Medical College, The First Affiliated Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Nanchang, Jiangxi Province, ChinaNanchang University, Jiangxi Medical College, The First Affiliated Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Nanchang, Jiangxi Province, China; Nanchang University, Jiangxi Medical College, The First Affiliated Hospital, Department of Allergy, Nanchang, Jiangxi Province, ChinaNanchang University, Jiangxi Medical College, The First Affiliated Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Nanchang, Jiangxi Province, China; Jiangxi Medicine Academy of Nutrition and Health Management, Nanchang, Jiangxi Province, China; Nanchang University, Jiangxi Medical College, The First Affiliated Hospital, Department of Allergy, Nanchang, Jiangxi Province, China; Nanchang University, Jiangxi Medical College, The First Affiliated Hospital, Institute of Otorhinolaryngology, Nanchang, Jiangxi Province, China; Corresponding author.Objective: This study aims to employ Mendelian Randomization (MR) analysis to investigate causal relationships between serum metabolites and CRS, identifying key pathogenic and protective factors and analyzing their mechanisms of action. Methods: Utilizing data from the Genome-Wide Association Studies (GWAS) database, employing two-sample MR analysis to investigate the potential causal relationship between 233 circulating metabolites with the occurrence of CRS. Inverse Variance Weighted (IVW) model, MR-Egger method, Weighted Median, and Weighted model were employed. Sensitivity analyses were conducted with Bonferroni correction. This research aims to elucidate the impact of metabolites on the development and progression of CRS, providing valuable insights into the underlying mechanisms. Results: Following MR analysis, two metabolites were significantly associated with CRS: Tyrosine (OR = 1.223; 95% CI 1.115–1.341; p = 1.96E-05) and Creatinine (OR = 1.208; 95% CI 1.103–1.322; p = 4.11E-05). These two key risk factors may be further studied for their pathogenesis and could be targeted for modulation in the treatment of CRS. However, there are several protective factors also worth exploring, among which the correlation is more significant: Ratio of conjugated linoleic acid to total fatty acids (OR = 0.809; 95% CI 0.708‒0.923; p = 1.73E-03), Albumin (OR = 0.787; 95% CI 0.670‒0.926; p = 3.76E-03),Conjugated linoleic acid (OR = 0.664; 95% CI 0.491‒0.898; p = 7.85E-03), Diacylglycerol (OR = 0.804; 95% CI 0.654‒0.989; p = 3.87E-02), Apolipoprotein A–I (OR = 0.915; 95% CI 0.845‒0.991; p = 2.89E-02). Conclusion: In our MR study, we discovered 28 circulating metabolites linked to CRS. Importantly, tyrosine and creatinine were identified as the most significant contributors to the pathogenesis of CRS, highlighting their potential as therapeutic targets. Additionally, several protective factors may offer new avenues for preventive strategies and therapeutic interventions. These findings underscore the clinical relevance of targeting these metabolites to modulate CRS progression and improve patient outcomes. Level of evidence: Level 2*.1http://www.sciencedirect.com/science/article/pii/S1808869425000692Chronic rhinosinusitisMendelian randomizationCirculating metabolites |
| spellingShingle | Fan Jiang Junhao Tu Wenqi Luo Yizhen Jia Qing Luo Jing Ye Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis Brazilian Journal of Otorhinolaryngology Chronic rhinosinusitis Mendelian randomization Circulating metabolites |
| title | Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis |
| title_full | Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis |
| title_fullStr | Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis |
| title_full_unstemmed | Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis |
| title_short | Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis |
| title_sort | identification of circulating metabolites associated with chronic rhinosinusitis using mendelian randomization analysis |
| topic | Chronic rhinosinusitis Mendelian randomization Circulating metabolites |
| url | http://www.sciencedirect.com/science/article/pii/S1808869425000692 |
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