Evaluation of the Effectiveness of Chitosan-Modified Bone Regeneration Materials: A Systematic Review
<b>Background/Objectives</b>: Today, regenerative therapy is routinely utilized in both medical and dental practices. Its outstanding results are due to the continuous development of technology and the invention of modern, more advanced biomaterials. The overarching idea in current regen...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/17/5/665 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850256048727785472 |
|---|---|
| author | Tsvetalina Gerova-Vatsova Stefan Peev Ralitsa Yotsova Varvara-Velika Rogova |
| author_facet | Tsvetalina Gerova-Vatsova Stefan Peev Ralitsa Yotsova Varvara-Velika Rogova |
| author_sort | Tsvetalina Gerova-Vatsova |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Today, regenerative therapy is routinely utilized in both medical and dental practices. Its outstanding results are due to the continuous development of technology and the invention of modern, more advanced biomaterials. The overarching idea in current regenerative therapy has shifted in the direction of the materials applied being osseointegrative, bioactive, responsive to stimuli from the body and actively promoting the overall regeneration of natural bone tissue. The aim is to determine whether chitosan is a material capable of improving the biological properties of different types of bone regeneration materials and, if so, which biological properties are affected. <b>Methods</b>: After going through the eligibility criteria, twenty articles, with a total of seventeen in vitro studies and six in vivo studies (some articles consisting of both), were included in this study. <b>Results</b>: The results presented colorimetric assays as the most commonly used methods investigating biological properties in in vitro studies, while in in vivo studies, researchers mainly rely on radiological and histological evaluation. After analyzing the data in this systematic review, it is clear that in vitro studies found a clear advantage of the results of chitosan-modified bone grafts in terms of bioactivity, osteogenic potential, biomineralization potential, biodegradability and antibacterial activity. In in vivo studies, chitosan-modified bone grafts stood out with better results in biocompatibility, osteogenic ability and biodegradability. <b>Conclusions</b>: In conclusion, it can be noted that chitosan-modified bone grafts have proven efficacy and the influence of chitosan is evidently favorable in terms of biological properties. |
| format | Article |
| id | doaj-art-ac70ec369e544e678e028d769df658bc |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-ac70ec369e544e678e028d769df658bc2025-08-20T01:56:44ZengMDPI AGPharmaceutics1999-49232025-05-0117566510.3390/pharmaceutics17050665Evaluation of the Effectiveness of Chitosan-Modified Bone Regeneration Materials: A Systematic ReviewTsvetalina Gerova-Vatsova0Stefan Peev1Ralitsa Yotsova2Varvara-Velika Rogova3Department of Periodontology and Dental Implantology, Faculty of Dental Medicine, Medical University of Varna, 9002 Varna, BulgariaDepartment of Periodontology and Dental Implantology, Faculty of Dental Medicine, Medical University of Varna, 9002 Varna, BulgariaDepartment of Oral Surgery, Faculty of Dental Medicine, Medical University of Varna, 9002 Varna, BulgariaDepartment of Oral Surgery, Faculty of Dental Medicine, Medical University of Varna, 9002 Varna, Bulgaria<b>Background/Objectives</b>: Today, regenerative therapy is routinely utilized in both medical and dental practices. Its outstanding results are due to the continuous development of technology and the invention of modern, more advanced biomaterials. The overarching idea in current regenerative therapy has shifted in the direction of the materials applied being osseointegrative, bioactive, responsive to stimuli from the body and actively promoting the overall regeneration of natural bone tissue. The aim is to determine whether chitosan is a material capable of improving the biological properties of different types of bone regeneration materials and, if so, which biological properties are affected. <b>Methods</b>: After going through the eligibility criteria, twenty articles, with a total of seventeen in vitro studies and six in vivo studies (some articles consisting of both), were included in this study. <b>Results</b>: The results presented colorimetric assays as the most commonly used methods investigating biological properties in in vitro studies, while in in vivo studies, researchers mainly rely on radiological and histological evaluation. After analyzing the data in this systematic review, it is clear that in vitro studies found a clear advantage of the results of chitosan-modified bone grafts in terms of bioactivity, osteogenic potential, biomineralization potential, biodegradability and antibacterial activity. In in vivo studies, chitosan-modified bone grafts stood out with better results in biocompatibility, osteogenic ability and biodegradability. <b>Conclusions</b>: In conclusion, it can be noted that chitosan-modified bone grafts have proven efficacy and the influence of chitosan is evidently favorable in terms of biological properties.https://www.mdpi.com/1999-4923/17/5/665chitosanbone graftbone substitutebone regenerationbiological properties |
| spellingShingle | Tsvetalina Gerova-Vatsova Stefan Peev Ralitsa Yotsova Varvara-Velika Rogova Evaluation of the Effectiveness of Chitosan-Modified Bone Regeneration Materials: A Systematic Review Pharmaceutics chitosan bone graft bone substitute bone regeneration biological properties |
| title | Evaluation of the Effectiveness of Chitosan-Modified Bone Regeneration Materials: A Systematic Review |
| title_full | Evaluation of the Effectiveness of Chitosan-Modified Bone Regeneration Materials: A Systematic Review |
| title_fullStr | Evaluation of the Effectiveness of Chitosan-Modified Bone Regeneration Materials: A Systematic Review |
| title_full_unstemmed | Evaluation of the Effectiveness of Chitosan-Modified Bone Regeneration Materials: A Systematic Review |
| title_short | Evaluation of the Effectiveness of Chitosan-Modified Bone Regeneration Materials: A Systematic Review |
| title_sort | evaluation of the effectiveness of chitosan modified bone regeneration materials a systematic review |
| topic | chitosan bone graft bone substitute bone regeneration biological properties |
| url | https://www.mdpi.com/1999-4923/17/5/665 |
| work_keys_str_mv | AT tsvetalinagerovavatsova evaluationoftheeffectivenessofchitosanmodifiedboneregenerationmaterialsasystematicreview AT stefanpeev evaluationoftheeffectivenessofchitosanmodifiedboneregenerationmaterialsasystematicreview AT ralitsayotsova evaluationoftheeffectivenessofchitosanmodifiedboneregenerationmaterialsasystematicreview AT varvaravelikarogova evaluationoftheeffectivenessofchitosanmodifiedboneregenerationmaterialsasystematicreview |