The host cell factor DDX3 mediates sex dimorphism in the IFNα response of plasmacytoid dendritic cells upon TLR activation

During the course of viral infections, IFN-I producing pDCs are fundamental in establishing antiviral defense. However, little is known about the molecular mechanisms by which biological sex contributes to differences in IFN-I production by pDCs. Here, we aimed to identify X-chromosome-encoded prote...

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Bibliographic Details
Main Authors: Sebastian Schloer, Jana Hennesen, Lena Rueschpler, Mohamed Zamzamy, Felix Flomm, Wing Hang Ip, Andrea Pirosu, Thomas Dobner, Marcus Altfeld
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Pharmacological Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825001896
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