The host cell factor DDX3 mediates sex dimorphism in the IFNα response of plasmacytoid dendritic cells upon TLR activation

The host cell factor DDX3 mediates sex dimorphism in the IFNα response of plasmacytoid dendritic cells upon TLR activation

During the course of viral infections, IFN-I producing pDCs are fundamental in establishing antiviral defense. However, little is known about the molecular mechanisms by which biological sex contributes to differences in IFN-I production by pDCs. Here, we aimed to identify X-chromosome-encoded prote...

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Bibliographic Details
Main Authors: Sebastian Schloer, Jana Hennesen, Lena Rueschpler, Mohamed Zamzamy, Felix Flomm, Wing Hang Ip, Andrea Pirosu, Thomas Dobner, Marcus Altfeld
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Pharmacological Research
Subjects:
Innate immunity
Plasmacytoid dendritic cells
Interferons
Sex differences
DDX3
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825001896
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