A Prospective Clinical Study to Assess the Hemodynamic Changes and Safety of 0.5% Levobupivacaine Hyperbaric for Spinal Anaesthesia in Adult Patients
Background: This study evaluates the hemodynamic effects safety and block characteristics of 0.5% hyperbaric levobupivacaine for spinal anesthesia in adults undergoing infraumbilical surgeries. Materials and Methods: A prospective study was conducted with 75 ASA I–II patients aged 18–65 years. Each...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_32_25 |
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| author | Kaushal Kabir Ashish Malviya Madhuri Bharang Aseem Sharma Gireesh Tyagi Manish Banjare |
| author_facet | Kaushal Kabir Ashish Malviya Madhuri Bharang Aseem Sharma Gireesh Tyagi Manish Banjare |
| author_sort | Kaushal Kabir |
| collection | DOAJ |
| description | Background:
This study evaluates the hemodynamic effects safety and block characteristics of 0.5% hyperbaric levobupivacaine for spinal anesthesia in adults undergoing infraumbilical surgeries.
Materials and Methods:
A prospective study was conducted with 75 ASA I–II patients aged 18–65 years. Each patient received 3.5 ml of 0.5% hyperbaric levobupivacaine at the L2/L3 or L3/L4 level. Hemodynamic parameters were monitored, and sensory and motor block characteristics were assessed. Postoperative pain was recorded using the Visual Analog Scale (VAS).
Results:
Hemodynamic stability was observed, with 2.66% of patients experiencing hypotension and none reporting bradycardia. Sensory block onset averaged 2.37 ± 0.70 min, lasting 201.35 ± 16.50 min. Motor block onset was 4.57 ± 0.54 min, lasting 171.27 ± 7.57 min. Severe pain (VAS ≥4) occurred in 62.6% at 4 hours and 38.6% at 8 hours.
Conclusions:
Hyperbaric 0.5% levobupivacaine provides effective anesthesia with stable hemodynamics. However, shorter analgesia duration suggests a need for additional postoperative pain management. |
| format | Article |
| id | doaj-art-ac6228d3ebb3481fa37e7f385c7fe21a |
| institution | OA Journals |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-ac6228d3ebb3481fa37e7f385c7fe21a2025-08-20T02:34:36ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-05-0117Suppl 1S360S36210.4103/jpbs.jpbs_32_25A Prospective Clinical Study to Assess the Hemodynamic Changes and Safety of 0.5% Levobupivacaine Hyperbaric for Spinal Anaesthesia in Adult PatientsKaushal KabirAshish MalviyaMadhuri BharangAseem SharmaGireesh TyagiManish BanjareBackground: This study evaluates the hemodynamic effects safety and block characteristics of 0.5% hyperbaric levobupivacaine for spinal anesthesia in adults undergoing infraumbilical surgeries. Materials and Methods: A prospective study was conducted with 75 ASA I–II patients aged 18–65 years. Each patient received 3.5 ml of 0.5% hyperbaric levobupivacaine at the L2/L3 or L3/L4 level. Hemodynamic parameters were monitored, and sensory and motor block characteristics were assessed. Postoperative pain was recorded using the Visual Analog Scale (VAS). Results: Hemodynamic stability was observed, with 2.66% of patients experiencing hypotension and none reporting bradycardia. Sensory block onset averaged 2.37 ± 0.70 min, lasting 201.35 ± 16.50 min. Motor block onset was 4.57 ± 0.54 min, lasting 171.27 ± 7.57 min. Severe pain (VAS ≥4) occurred in 62.6% at 4 hours and 38.6% at 8 hours. Conclusions: Hyperbaric 0.5% levobupivacaine provides effective anesthesia with stable hemodynamics. However, shorter analgesia duration suggests a need for additional postoperative pain management.https://journals.lww.com/10.4103/jpbs.jpbs_32_25hemodynamic stabilityinfraumbilical surgerieslevobupivacainemotor and sensory blockpostoperative analgesiaspinal anesthesia |
| spellingShingle | Kaushal Kabir Ashish Malviya Madhuri Bharang Aseem Sharma Gireesh Tyagi Manish Banjare A Prospective Clinical Study to Assess the Hemodynamic Changes and Safety of 0.5% Levobupivacaine Hyperbaric for Spinal Anaesthesia in Adult Patients Journal of Pharmacy and Bioallied Sciences hemodynamic stability infraumbilical surgeries levobupivacaine motor and sensory block postoperative analgesia spinal anesthesia |
| title | A Prospective Clinical Study to Assess the Hemodynamic Changes and Safety of 0.5% Levobupivacaine Hyperbaric for Spinal Anaesthesia in Adult Patients |
| title_full | A Prospective Clinical Study to Assess the Hemodynamic Changes and Safety of 0.5% Levobupivacaine Hyperbaric for Spinal Anaesthesia in Adult Patients |
| title_fullStr | A Prospective Clinical Study to Assess the Hemodynamic Changes and Safety of 0.5% Levobupivacaine Hyperbaric for Spinal Anaesthesia in Adult Patients |
| title_full_unstemmed | A Prospective Clinical Study to Assess the Hemodynamic Changes and Safety of 0.5% Levobupivacaine Hyperbaric for Spinal Anaesthesia in Adult Patients |
| title_short | A Prospective Clinical Study to Assess the Hemodynamic Changes and Safety of 0.5% Levobupivacaine Hyperbaric for Spinal Anaesthesia in Adult Patients |
| title_sort | prospective clinical study to assess the hemodynamic changes and safety of 0 5 levobupivacaine hyperbaric for spinal anaesthesia in adult patients |
| topic | hemodynamic stability infraumbilical surgeries levobupivacaine motor and sensory block postoperative analgesia spinal anesthesia |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_32_25 |
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