A Prospective Clinical Study to Assess the Hemodynamic Changes and Safety of 0.5% Levobupivacaine Hyperbaric for Spinal Anaesthesia in Adult Patients
Background: This study evaluates the hemodynamic effects safety and block characteristics of 0.5% hyperbaric levobupivacaine for spinal anesthesia in adults undergoing infraumbilical surgeries. Materials and Methods: A prospective study was conducted with 75 ASA I–II patients aged 18–65 years. Each...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_32_25 |
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| Summary: | Background:
This study evaluates the hemodynamic effects safety and block characteristics of 0.5% hyperbaric levobupivacaine for spinal anesthesia in adults undergoing infraumbilical surgeries.
Materials and Methods:
A prospective study was conducted with 75 ASA I–II patients aged 18–65 years. Each patient received 3.5 ml of 0.5% hyperbaric levobupivacaine at the L2/L3 or L3/L4 level. Hemodynamic parameters were monitored, and sensory and motor block characteristics were assessed. Postoperative pain was recorded using the Visual Analog Scale (VAS).
Results:
Hemodynamic stability was observed, with 2.66% of patients experiencing hypotension and none reporting bradycardia. Sensory block onset averaged 2.37 ± 0.70 min, lasting 201.35 ± 16.50 min. Motor block onset was 4.57 ± 0.54 min, lasting 171.27 ± 7.57 min. Severe pain (VAS ≥4) occurred in 62.6% at 4 hours and 38.6% at 8 hours.
Conclusions:
Hyperbaric 0.5% levobupivacaine provides effective anesthesia with stable hemodynamics. However, shorter analgesia duration suggests a need for additional postoperative pain management. |
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| ISSN: | 0976-4879 0975-7406 |