The Potential of Matrine in the Treatment of Breast Cancer: A Review
Breast cancer ranks as the fifth-most-prevalent malignancy worldwide, characterized by high heterogeneity and multifactorial etiology across molecular subtypes. Despite advancements in conventional therapies, including surgery and chemotherapy, persistent challenges such as treatment-related adverse...
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MDPI AG
2025-05-01
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| author | Yumin Yang Yufeng Li Shanshan Liao Pan Gao Jie Tian Cheng Fu Xuhua Qin Shenrui Jin |
| author_facet | Yumin Yang Yufeng Li Shanshan Liao Pan Gao Jie Tian Cheng Fu Xuhua Qin Shenrui Jin |
| author_sort | Yumin Yang |
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| description | Breast cancer ranks as the fifth-most-prevalent malignancy worldwide, characterized by high heterogeneity and multifactorial etiology across molecular subtypes. Despite advancements in conventional therapies, including surgery and chemotherapy, persistent challenges such as treatment-related adverse effects and acquired drug resistance necessitate alternative therapeutic strategies. Matrine, a naturally occurring alkaloid derived from Sophora flavescens, has demonstrated significant anticancer potential through multiple mechanisms. Experimental evidence indicates that matrine exerts inhibitory effects on tumor cell proliferation, promotes apoptosis, and attenuates metastatic progression via modulation of critical signaling pathways, particularly PI3K/Akt, JAK/STAT, NF-κB, MAPK/ERK, and Wnt/β-catenin. This review systematically examines subtype-specific responses to matrine treatment, highlighting its potential utility in precision oncology for distinct breast cancer classifications. Furthermore, we evaluate matrine’s capacity to synergize with standard chemotherapeutic regimens, potentially overcoming drug resistance while reducing required dosages. By integrating current preclinical and clinical findings, this analysis provides new perspectives on matrine’s therapeutic applications and underscores the imperative for translational studies to establish optimized treatment protocols for clinical implementation. |
| format | Article |
| id | doaj-art-ac5bee638eba40b9bdb50cfddbea6ec8 |
| institution | OA Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-ac5bee638eba40b9bdb50cfddbea6ec82025-08-20T02:24:18ZengMDPI AGBiomedicines2227-90592025-05-01136135510.3390/biomedicines13061355The Potential of Matrine in the Treatment of Breast Cancer: A ReviewYumin Yang0Yufeng Li1Shanshan Liao2Pan Gao3Jie Tian4Cheng Fu5Xuhua Qin6Shenrui Jin7College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaBreast cancer ranks as the fifth-most-prevalent malignancy worldwide, characterized by high heterogeneity and multifactorial etiology across molecular subtypes. Despite advancements in conventional therapies, including surgery and chemotherapy, persistent challenges such as treatment-related adverse effects and acquired drug resistance necessitate alternative therapeutic strategies. Matrine, a naturally occurring alkaloid derived from Sophora flavescens, has demonstrated significant anticancer potential through multiple mechanisms. Experimental evidence indicates that matrine exerts inhibitory effects on tumor cell proliferation, promotes apoptosis, and attenuates metastatic progression via modulation of critical signaling pathways, particularly PI3K/Akt, JAK/STAT, NF-κB, MAPK/ERK, and Wnt/β-catenin. This review systematically examines subtype-specific responses to matrine treatment, highlighting its potential utility in precision oncology for distinct breast cancer classifications. Furthermore, we evaluate matrine’s capacity to synergize with standard chemotherapeutic regimens, potentially overcoming drug resistance while reducing required dosages. By integrating current preclinical and clinical findings, this analysis provides new perspectives on matrine’s therapeutic applications and underscores the imperative for translational studies to establish optimized treatment protocols for clinical implementation.https://www.mdpi.com/2227-9059/13/6/1355matrinebreast canceranti-tumormechanismtraditional Chinese medicine monomer |
| spellingShingle | Yumin Yang Yufeng Li Shanshan Liao Pan Gao Jie Tian Cheng Fu Xuhua Qin Shenrui Jin The Potential of Matrine in the Treatment of Breast Cancer: A Review Biomedicines matrine breast cancer anti-tumor mechanism traditional Chinese medicine monomer |
| title | The Potential of Matrine in the Treatment of Breast Cancer: A Review |
| title_full | The Potential of Matrine in the Treatment of Breast Cancer: A Review |
| title_fullStr | The Potential of Matrine in the Treatment of Breast Cancer: A Review |
| title_full_unstemmed | The Potential of Matrine in the Treatment of Breast Cancer: A Review |
| title_short | The Potential of Matrine in the Treatment of Breast Cancer: A Review |
| title_sort | potential of matrine in the treatment of breast cancer a review |
| topic | matrine breast cancer anti-tumor mechanism traditional Chinese medicine monomer |
| url | https://www.mdpi.com/2227-9059/13/6/1355 |
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