The Effect of Intraoperative Boost Dose Radiotherapy on Wound Complications in Breast Cancer Patients Operated with Upper Outer Quadrantectomy by Using Intraglandular Flap Mobilization Technique
Aim: In this study, the technical aspects of intraoperative radiotherapy (IORT) application and its effect on early wound complications were evaluated. Methods: Fifty consecutive patients operated with upper outer quadrantectomy and intraglandular flap mobilisation and given IORT between 2013 and 2...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2025-08-01
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| Series: | Acta Haematologica Oncologica Turcica |
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| Online Access: | https://www.actaoncologicaturcica.com/articles/the-effect-of-intraoperative-boost-dose-radiotherapy-on-wound-complications-in-breast-cancer-patients-operated-with-upper-outer-quadrantectomy-by-using-intraglandular-flap-mobilization-technique/doi/ahot.galenos.2025.2025-5-3 |
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| author | Mujdat Turan Niyazi Karaman Lutfi Dogan Mehmet Ali Gulcelik |
| author_facet | Mujdat Turan Niyazi Karaman Lutfi Dogan Mehmet Ali Gulcelik |
| author_sort | Mujdat Turan |
| collection | DOAJ |
| description | Aim: In this study, the technical aspects of intraoperative radiotherapy (IORT) application and its effect on early wound complications were evaluated.
Methods: Fifty consecutive patients operated with upper outer quadrantectomy and intraglandular flap mobilisation and given IORT between 2013 and 2014 were included. Radiotherapy at a boost dose of 10 Gy was given to 21 patients. The control group consisted of 29 patients who were operated with the same surgical technique but were not given IORT.
Results: The median age of the patients was 51.5±10.9 years. The average specimen weight was 266±83 g. The surgical resection margin evaluation with frozen section was negative in all patients. Four patients were reported to have involved margins at permanent sections. When both groups were compared in terms of early postoperative complications, there were 6 (28.5%) patients with seroma in the IORT group and 2 patients (6.8%) in the control group. While 5 (23.8%) patients were seen to have surgical site infection (SSI) in the IORT group, there was no SSI in the control group. There were 7 (33.3%) patients with delayed wound healing in the IORT group and 2 patients (6.8%) in the control group. While 2 (6.8%) patients had hematoma in the control group, there was no hematoma in the IORT group. While one (4.7%) patient was seen to have minor wound dehiscence in the IORT group, there was no wound dehiscence in the control group.
Conclusion: In this study, we concluded that IORT may negatively impact wound healing by increasing the incidence of seroma, SSI, and delayed wound healing in patients undergoing oncoplastic breast surgery. Increased awareness and preventive measures are necessary, especially in centers newly implementing IORT. |
| format | Article |
| id | doaj-art-ac5bd7d59e744affbe99ca1f3574bc52 |
| institution | Kabale University |
| issn | 3061-9947 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Acta Haematologica Oncologica Turcica |
| spelling | doaj-art-ac5bd7d59e744affbe99ca1f3574bc522025-08-20T03:43:54ZengGalenos Publishing HouseActa Haematologica Oncologica Turcica3061-99472025-08-01582879210.4274/ahot.galenos.2025.2025-5-3The Effect of Intraoperative Boost Dose Radiotherapy on Wound Complications in Breast Cancer Patients Operated with Upper Outer Quadrantectomy by Using Intraglandular Flap Mobilization TechniqueMujdat Turan0https://orcid.org/0000-0002-7854-4855Niyazi Karaman1https://orcid.org/0000-0001-9875-7017Lutfi Dogan2https://orcid.org/0000-0001-5214-3597Mehmet Ali Gulcelik3https://orcid.org/0000-0002-8967-7303University of Health Sciences Türkiye, Ankara Gulhane Training and Research Hospital, Clinic of General Surgery, Ankara, TürkiyeUniversity of Health Sciences Türkiye, Ankara Oncology Training and Research Hospital, Clinic of General Surgery, Ankara, TürkiyeUniversity of Health Sciences Türkiye, Ankara Etlik City Hospital, Clinic of Surgical Oncology, Ankara, TürkiyeUniversity of Health Sciences Türkiye, Gulhane Faculty of Medicine Training and Research Hospital, Department of Surgical Oncology, Ankara, TürkiyeAim: In this study, the technical aspects of intraoperative radiotherapy (IORT) application and its effect on early wound complications were evaluated. Methods: Fifty consecutive patients operated with upper outer quadrantectomy and intraglandular flap mobilisation and given IORT between 2013 and 2014 were included. Radiotherapy at a boost dose of 10 Gy was given to 21 patients. The control group consisted of 29 patients who were operated with the same surgical technique but were not given IORT. Results: The median age of the patients was 51.5±10.9 years. The average specimen weight was 266±83 g. The surgical resection margin evaluation with frozen section was negative in all patients. Four patients were reported to have involved margins at permanent sections. When both groups were compared in terms of early postoperative complications, there were 6 (28.5%) patients with seroma in the IORT group and 2 patients (6.8%) in the control group. While 5 (23.8%) patients were seen to have surgical site infection (SSI) in the IORT group, there was no SSI in the control group. There were 7 (33.3%) patients with delayed wound healing in the IORT group and 2 patients (6.8%) in the control group. While 2 (6.8%) patients had hematoma in the control group, there was no hematoma in the IORT group. While one (4.7%) patient was seen to have minor wound dehiscence in the IORT group, there was no wound dehiscence in the control group. Conclusion: In this study, we concluded that IORT may negatively impact wound healing by increasing the incidence of seroma, SSI, and delayed wound healing in patients undergoing oncoplastic breast surgery. Increased awareness and preventive measures are necessary, especially in centers newly implementing IORT.https://www.actaoncologicaturcica.com/articles/the-effect-of-intraoperative-boost-dose-radiotherapy-on-wound-complications-in-breast-cancer-patients-operated-with-upper-outer-quadrantectomy-by-using-intraglandular-flap-mobilization-technique/doi/ahot.galenos.2025.2025-5-3breast cancerbreast conserving surgerycomplicationintraoperative radiotherapy |
| spellingShingle | Mujdat Turan Niyazi Karaman Lutfi Dogan Mehmet Ali Gulcelik The Effect of Intraoperative Boost Dose Radiotherapy on Wound Complications in Breast Cancer Patients Operated with Upper Outer Quadrantectomy by Using Intraglandular Flap Mobilization Technique Acta Haematologica Oncologica Turcica breast cancer breast conserving surgery complication intraoperative radiotherapy |
| title | The Effect of Intraoperative Boost Dose Radiotherapy on Wound Complications in Breast Cancer Patients Operated with Upper Outer Quadrantectomy by Using Intraglandular Flap Mobilization Technique |
| title_full | The Effect of Intraoperative Boost Dose Radiotherapy on Wound Complications in Breast Cancer Patients Operated with Upper Outer Quadrantectomy by Using Intraglandular Flap Mobilization Technique |
| title_fullStr | The Effect of Intraoperative Boost Dose Radiotherapy on Wound Complications in Breast Cancer Patients Operated with Upper Outer Quadrantectomy by Using Intraglandular Flap Mobilization Technique |
| title_full_unstemmed | The Effect of Intraoperative Boost Dose Radiotherapy on Wound Complications in Breast Cancer Patients Operated with Upper Outer Quadrantectomy by Using Intraglandular Flap Mobilization Technique |
| title_short | The Effect of Intraoperative Boost Dose Radiotherapy on Wound Complications in Breast Cancer Patients Operated with Upper Outer Quadrantectomy by Using Intraglandular Flap Mobilization Technique |
| title_sort | effect of intraoperative boost dose radiotherapy on wound complications in breast cancer patients operated with upper outer quadrantectomy by using intraglandular flap mobilization technique |
| topic | breast cancer breast conserving surgery complication intraoperative radiotherapy |
| url | https://www.actaoncologicaturcica.com/articles/the-effect-of-intraoperative-boost-dose-radiotherapy-on-wound-complications-in-breast-cancer-patients-operated-with-upper-outer-quadrantectomy-by-using-intraglandular-flap-mobilization-technique/doi/ahot.galenos.2025.2025-5-3 |
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