The significance of ANGPTL3 and ANGPTL4 proteins in the development of dyslipidemia in Type 2 diabetes mellitus
Background: Dyslipidemia is the leading cause of cardiovascular disease (CVD) in Type 2 diabetes mellitus patients. As a result, it is critical to target and manage the level of atherogenic lipids. Angiopoietin-like proteins 3 and 4 (ANGPTL 3 and ANGPTL 4) play an important role in the intravascular...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-03-01
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| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_1256_24 |
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| Summary: | Background:
Dyslipidemia is the leading cause of cardiovascular disease (CVD) in Type 2 diabetes mellitus patients. As a result, it is critical to target and manage the level of atherogenic lipids. Angiopoietin-like proteins 3 and 4 (ANGPTL 3 and ANGPTL 4) play an important role in the intravascular lipolysis of triglyceride-rich lipoproteins by blocking the enzyme lipoprotein lipase. This study aimed to determine the amounts of these angiopoietin-like proteins in T2DM and find their association with dyslipidemia in T2DM.
Material and Methods:
Sixty-one T2DM patients of age group 25–65 years and 27 healthy age-matched control participants were enrolled in the study. Glycemic status (FBS, PPBS, HbA1C), serum lipid parameters (cholesterol, TG, LDL, VLDL, HDL, Tc/HDL ratio), free fatty acid, serum insulin, and ANGPTL3, 4 were measured. A correlation was found between the ANGPTLs and the above parameters in T2DM patients.
Results:
Serum ANGPTL3 (P < 0.05) and ANGPTL4 (P < 0.001) were significantly decreased in T2DM. ANGPTL4 was also negatively correlated to PPBS (0.03), HbA1C (P = 0.05), and IR (P = 0.04). However, no such correlation was observed with ANGPTL 3. It was observed that lipid parameters were correlated with ANGPTL3 (LDL (P = 0.03), TC/HDL (P = 0.02)). There was a significant relationship between ANGPTL3 and 4 with FFA (P = 0.001 and P = 0.03, respectively).
Conclusion:
This study shows that ANGPTL 3,4 may be associated with dyslipidemia in T2DM. ANGPTL4 is more correlated with glycemic status. |
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| ISSN: | 2249-4863 2278-7135 |