Long-lasting residual efficacy of a new indoor residual spraying product, VECTRON™ T500 (broflanilide), against pyrethroid-resistant malaria vectors and its acceptance in a community trial in Burkina Faso
Abstract Background The WHO Global Malaria Programme advocates for a comprehensive, strategic approach to managing insecticide resistance, highlighting the importance of using multiple insecticides with different modes of action through rotations and combinations. To slow the spread of resistance, i...
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BMC
2024-11-01
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| Series: | Parasites & Vectors |
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| Online Access: | https://doi.org/10.1186/s13071-024-06577-y |
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| author | Aristide Sawdetuo Hien Koama Bayili Samina Maiga Welbeck Oumbouke Jean Birba Dieudonné Diloma Soma Adissa Ya Ouattara Delphine Ouissamien Karama Marlize Coleman Janneke Snetselaar Graham Small Shinya Niimi Kawase Ayumi Sidzabda Kompaoré Katsutoshi Tsuchiya Roch Kounbobr Dabiré Abdoulaye Diabaté |
| author_facet | Aristide Sawdetuo Hien Koama Bayili Samina Maiga Welbeck Oumbouke Jean Birba Dieudonné Diloma Soma Adissa Ya Ouattara Delphine Ouissamien Karama Marlize Coleman Janneke Snetselaar Graham Small Shinya Niimi Kawase Ayumi Sidzabda Kompaoré Katsutoshi Tsuchiya Roch Kounbobr Dabiré Abdoulaye Diabaté |
| author_sort | Aristide Sawdetuo Hien |
| collection | DOAJ |
| description | Abstract Background The WHO Global Malaria Programme advocates for a comprehensive, strategic approach to managing insecticide resistance, highlighting the importance of using multiple insecticides with different modes of action through rotations and combinations. To slow the spread of resistance, it is essential to develop and evaluate new formulations that feature unique modes of action and extended residual effects. Addressing this need, Mitsui Chemicals Crop & Life Solutions, Inc., developed VECTRON™ T500, a new indoor residual spraying (IRS) formulation using broflanilide, applied at a dosage of 100 mg AI/m2. This formulation was tested in a Phase III community trial, alongside Actellic® 300CS, a commonly used IRS product containing pirimiphos-methyl, applied at the recommended dosage of 1000 mg AI/m2. Methods Monthly WHO wall cone bioassays were performed to assess the efficacy of the interventions using three mosquito strains: the laboratory-bred, insecticide-susceptible Anopheles gambiae s.s. Kisumu strain, the insecticide-resistant Anopheles coluzzii VKPer strain, and wild Anopheles gambiae s.l. mosquitoes from the Vallée du Kou, where the study was conducted. Vector surveillance was carried out to compare the results between sites treated with VECTRON™ T500, Actellic® 300CS, and an untreated control site. In addition, any reported adverse effects were closely monitored to evaluate the community’s acceptance of VECTRON™ T500. Results VECTRON™ T500 consistently achieved 100% mortality across all wall types for both susceptible and resistant mosquito strains over the 12-month period. In comparison, Actellic® 300CS induced < 80% mortality for both strains, irrespective of the wall substrate. When assessing delayed mortality in An. gambiae s.l. mosquitoes collected from sites treated with Actellic® 300CS (VK1) and VECTRON™ T500 (VK3), a statistically significant difference was noted after a 72-h holding period compared to the control site (RR = 0.51, CI95% = [0.31–0.6], P = 0.0026). Additionally, no adverse events were reported in households sprayed with VECTRON™ T500. Conclusions The residual efficacy of VECTRON™ T500 extended for 12 months post-spraying, effectively covering the full malaria transmission season while maintaining high mortality rates in pyrethroid-resistant malaria vectors. VECTRON™ T500 demonstrated non-inferiority in performance compared to Actellic® 300CS, the standard reference product. This new IRS formulation has the potential to play a crucial role in managing insecticide resistance by being integrated into a rotational strategy alongside other IRS products containing insecticides with different modes of action. Graphical Abstract |
| format | Article |
| id | doaj-art-ac51383486c3401f8e84fe78e8e02e57 |
| institution | OA Journals |
| issn | 1756-3305 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj-art-ac51383486c3401f8e84fe78e8e02e572025-08-20T02:22:25ZengBMCParasites & Vectors1756-33052024-11-0117111510.1186/s13071-024-06577-yLong-lasting residual efficacy of a new indoor residual spraying product, VECTRON™ T500 (broflanilide), against pyrethroid-resistant malaria vectors and its acceptance in a community trial in Burkina FasoAristide Sawdetuo Hien0Koama Bayili1Samina Maiga2Welbeck Oumbouke3Jean Birba4Dieudonné Diloma Soma5Adissa Ya Ouattara6Delphine Ouissamien Karama7Marlize Coleman8Janneke Snetselaar9Graham Small10Shinya Niimi11Kawase Ayumi12Sidzabda Kompaoré13Katsutoshi Tsuchiya14Roch Kounbobr Dabiré15Abdoulaye Diabaté16Institut de Recherches en Sciences de la Santé, Centre National de la Recherche Scientifique et TechnologiqueInstitut de Recherches en Sciences de la Santé, Centre National de la Recherche Scientifique et TechnologiqueInstitut de Recherches en Sciences de la Santé, Centre National de la Recherche Scientifique et TechnologiqueInnovative Vector Control Consortium (IVCC)Institut de Recherches en Sciences de la Santé, Centre National de la Recherche Scientifique et TechnologiqueInstitut de Recherches en Sciences de la Santé, Centre National de la Recherche Scientifique et TechnologiqueInstitut de Recherches en Sciences de la Santé, Centre National de la Recherche Scientifique et TechnologiqueInstitut de Recherches en Sciences de la Santé, Centre National de la Recherche Scientifique et TechnologiqueInnovative Vector Control Consortium (IVCC)Innovative Vector Control Consortium (IVCC)Innovative Vector Control Consortium (IVCC)Mitsui Chemicals Crop & Life Solutions, Inc.Mitsui Chemicals Crop & Life Solutions, Inc.Permanent Secretariat for Malaria EliminationMitsui Chemicals Crop & Life Solutions, Inc.Institut de Recherches en Sciences de la Santé, Centre National de la Recherche Scientifique et TechnologiqueInstitut de Recherches en Sciences de la Santé, Centre National de la Recherche Scientifique et TechnologiqueAbstract Background The WHO Global Malaria Programme advocates for a comprehensive, strategic approach to managing insecticide resistance, highlighting the importance of using multiple insecticides with different modes of action through rotations and combinations. To slow the spread of resistance, it is essential to develop and evaluate new formulations that feature unique modes of action and extended residual effects. Addressing this need, Mitsui Chemicals Crop & Life Solutions, Inc., developed VECTRON™ T500, a new indoor residual spraying (IRS) formulation using broflanilide, applied at a dosage of 100 mg AI/m2. This formulation was tested in a Phase III community trial, alongside Actellic® 300CS, a commonly used IRS product containing pirimiphos-methyl, applied at the recommended dosage of 1000 mg AI/m2. Methods Monthly WHO wall cone bioassays were performed to assess the efficacy of the interventions using three mosquito strains: the laboratory-bred, insecticide-susceptible Anopheles gambiae s.s. Kisumu strain, the insecticide-resistant Anopheles coluzzii VKPer strain, and wild Anopheles gambiae s.l. mosquitoes from the Vallée du Kou, where the study was conducted. Vector surveillance was carried out to compare the results between sites treated with VECTRON™ T500, Actellic® 300CS, and an untreated control site. In addition, any reported adverse effects were closely monitored to evaluate the community’s acceptance of VECTRON™ T500. Results VECTRON™ T500 consistently achieved 100% mortality across all wall types for both susceptible and resistant mosquito strains over the 12-month period. In comparison, Actellic® 300CS induced < 80% mortality for both strains, irrespective of the wall substrate. When assessing delayed mortality in An. gambiae s.l. mosquitoes collected from sites treated with Actellic® 300CS (VK1) and VECTRON™ T500 (VK3), a statistically significant difference was noted after a 72-h holding period compared to the control site (RR = 0.51, CI95% = [0.31–0.6], P = 0.0026). Additionally, no adverse events were reported in households sprayed with VECTRON™ T500. Conclusions The residual efficacy of VECTRON™ T500 extended for 12 months post-spraying, effectively covering the full malaria transmission season while maintaining high mortality rates in pyrethroid-resistant malaria vectors. VECTRON™ T500 demonstrated non-inferiority in performance compared to Actellic® 300CS, the standard reference product. This new IRS formulation has the potential to play a crucial role in managing insecticide resistance by being integrated into a rotational strategy alongside other IRS products containing insecticides with different modes of action. Graphical Abstracthttps://doi.org/10.1186/s13071-024-06577-yVECTRON™ T500Actellic® 300CSIndoor residual sprayingAnopheles gambiae s.l.EfficacyBurkina Faso |
| spellingShingle | Aristide Sawdetuo Hien Koama Bayili Samina Maiga Welbeck Oumbouke Jean Birba Dieudonné Diloma Soma Adissa Ya Ouattara Delphine Ouissamien Karama Marlize Coleman Janneke Snetselaar Graham Small Shinya Niimi Kawase Ayumi Sidzabda Kompaoré Katsutoshi Tsuchiya Roch Kounbobr Dabiré Abdoulaye Diabaté Long-lasting residual efficacy of a new indoor residual spraying product, VECTRON™ T500 (broflanilide), against pyrethroid-resistant malaria vectors and its acceptance in a community trial in Burkina Faso Parasites & Vectors VECTRON™ T500 Actellic® 300CS Indoor residual spraying Anopheles gambiae s.l. Efficacy Burkina Faso |
| title | Long-lasting residual efficacy of a new indoor residual spraying product, VECTRON™ T500 (broflanilide), against pyrethroid-resistant malaria vectors and its acceptance in a community trial in Burkina Faso |
| title_full | Long-lasting residual efficacy of a new indoor residual spraying product, VECTRON™ T500 (broflanilide), against pyrethroid-resistant malaria vectors and its acceptance in a community trial in Burkina Faso |
| title_fullStr | Long-lasting residual efficacy of a new indoor residual spraying product, VECTRON™ T500 (broflanilide), against pyrethroid-resistant malaria vectors and its acceptance in a community trial in Burkina Faso |
| title_full_unstemmed | Long-lasting residual efficacy of a new indoor residual spraying product, VECTRON™ T500 (broflanilide), against pyrethroid-resistant malaria vectors and its acceptance in a community trial in Burkina Faso |
| title_short | Long-lasting residual efficacy of a new indoor residual spraying product, VECTRON™ T500 (broflanilide), against pyrethroid-resistant malaria vectors and its acceptance in a community trial in Burkina Faso |
| title_sort | long lasting residual efficacy of a new indoor residual spraying product vectron™ t500 broflanilide against pyrethroid resistant malaria vectors and its acceptance in a community trial in burkina faso |
| topic | VECTRON™ T500 Actellic® 300CS Indoor residual spraying Anopheles gambiae s.l. Efficacy Burkina Faso |
| url | https://doi.org/10.1186/s13071-024-06577-y |
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