Cohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA
Purpose We developed a comprehensive sleeve gastrectomy (SG) weight loss study cohort and biorepository to uncover mechanisms, biomarkers and predictive factors of weight loss, weight maintenance and amelioration of obesity-related comorbidities. For this purpose, we collected psychosocial, anthropo...
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BMJ Publishing Group
2024-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/8/e081201.full |
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| author | Melanie Jay Eran Segal Brian Elbel Jose O Aleman Sally M Vanegas Silvia Curado Akash Gujral Gabriela Valverde Susan Parraga Migdalia Reid Ann Marie Schmidt Sean P Heffron Huilin Li Courtney Abrams Mary A Sevick Collin Popp Evelyn Armijos Ericka N Merriwether Valentina Ivezaj Christine Ren-Fielding Manish Parikh |
| author_facet | Melanie Jay Eran Segal Brian Elbel Jose O Aleman Sally M Vanegas Silvia Curado Akash Gujral Gabriela Valverde Susan Parraga Migdalia Reid Ann Marie Schmidt Sean P Heffron Huilin Li Courtney Abrams Mary A Sevick Collin Popp Evelyn Armijos Ericka N Merriwether Valentina Ivezaj Christine Ren-Fielding Manish Parikh |
| author_sort | Melanie Jay |
| collection | DOAJ |
| description | Purpose We developed a comprehensive sleeve gastrectomy (SG) weight loss study cohort and biorepository to uncover mechanisms, biomarkers and predictive factors of weight loss, weight maintenance and amelioration of obesity-related comorbidities. For this purpose, we collected psychosocial, anthropometric, clinical data and a variety of samples pre-surgery, intraoperatively and 1.5, 3, 12 and 24 months post-surgery. For longer-term assessment, the collection of psychosocial and anthropometric data was extended to 10 years. Here, we present in-depth characterisation of the cohort and detailed overview of study procedures as a foundation for future analyses.Participants We consented 647 participants between June 2017 and March 2020 from two bariatric surgery clinics in New York City—one major urban hospital and one private hospital. Of 355 participants who provided baseline data, 300 underwent SG. Of these, 79% are females with an average age of 38 years, 68% are Hispanic, 20% are non-Hispanic Black and 11% are non-Hispanic White.Findings to date We collected intraoperative adipose and stomach tissues from 282 patients and biosamples (blood, urine, saliva, stool) from 245 patients at 1.5 months, 238 at 3 month, 218 at 12 months and 180 at 24 months post-surgery. We are currently collecting anthropometric and psychosocial data annually until 10 years post-surgery. Data analysis is currently underway.Future plans Our future research will explore the variability in weight loss outcomes observed in our cohort, particularly among Black and Hispanic patients in comparison to their White counterparts. We will identify social determinants of health, metabolic factors and other variables that may predict weight loss success, weight maintenance and remission of obesity-related comorbidities. Additionally, we plan to leverage our biorepository for collaborative research studies. We will complete long-term follow-up data by December 2031. We plan to apply for funding to expand biosample collection through year 10 to provide insights into the mechanisms of long-term weight maintenance. |
| format | Article |
| id | doaj-art-ac51210ff6fc4385a73df08362077f86 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-ac51210ff6fc4385a73df08362077f862025-08-20T02:12:55ZengBMJ Publishing GroupBMJ Open2044-60552024-09-0114810.1136/bmjopen-2023-081201Cohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USAMelanie Jay0Eran Segal1Brian Elbel2Jose O Aleman3Sally M Vanegas4Silvia Curado5Akash Gujral6Gabriela Valverde7Susan Parraga8Migdalia Reid9Ann Marie Schmidt10Sean P Heffron11Huilin Li12Courtney Abrams13Mary A Sevick14Collin Popp15Evelyn Armijos16Ericka N Merriwether17Valentina Ivezaj18Christine Ren-Fielding19Manish Parikh20Department of Population Health, New York University Grossman School of Medicine, New York, New York, USADepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, IsraelDepartment of Population Health, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USADepartment of Pathology, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USADepartment of Population Health, New York University Grossman School of Medicine, New York, New York, USADepartment of Population Health, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USADepartment of Population Health, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, New York University Grossman School of Medicine, New York, New York, USADepartment of Medicine, Yale University, New Haven, Connecticut, USADepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USADepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USAPurpose We developed a comprehensive sleeve gastrectomy (SG) weight loss study cohort and biorepository to uncover mechanisms, biomarkers and predictive factors of weight loss, weight maintenance and amelioration of obesity-related comorbidities. For this purpose, we collected psychosocial, anthropometric, clinical data and a variety of samples pre-surgery, intraoperatively and 1.5, 3, 12 and 24 months post-surgery. For longer-term assessment, the collection of psychosocial and anthropometric data was extended to 10 years. Here, we present in-depth characterisation of the cohort and detailed overview of study procedures as a foundation for future analyses.Participants We consented 647 participants between June 2017 and March 2020 from two bariatric surgery clinics in New York City—one major urban hospital and one private hospital. Of 355 participants who provided baseline data, 300 underwent SG. Of these, 79% are females with an average age of 38 years, 68% are Hispanic, 20% are non-Hispanic Black and 11% are non-Hispanic White.Findings to date We collected intraoperative adipose and stomach tissues from 282 patients and biosamples (blood, urine, saliva, stool) from 245 patients at 1.5 months, 238 at 3 month, 218 at 12 months and 180 at 24 months post-surgery. We are currently collecting anthropometric and psychosocial data annually until 10 years post-surgery. Data analysis is currently underway.Future plans Our future research will explore the variability in weight loss outcomes observed in our cohort, particularly among Black and Hispanic patients in comparison to their White counterparts. We will identify social determinants of health, metabolic factors and other variables that may predict weight loss success, weight maintenance and remission of obesity-related comorbidities. Additionally, we plan to leverage our biorepository for collaborative research studies. We will complete long-term follow-up data by December 2031. We plan to apply for funding to expand biosample collection through year 10 to provide insights into the mechanisms of long-term weight maintenance.https://bmjopen.bmj.com/content/14/8/e081201.full |
| spellingShingle | Melanie Jay Eran Segal Brian Elbel Jose O Aleman Sally M Vanegas Silvia Curado Akash Gujral Gabriela Valverde Susan Parraga Migdalia Reid Ann Marie Schmidt Sean P Heffron Huilin Li Courtney Abrams Mary A Sevick Collin Popp Evelyn Armijos Ericka N Merriwether Valentina Ivezaj Christine Ren-Fielding Manish Parikh Cohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA BMJ Open |
| title | Cohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA |
| title_full | Cohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA |
| title_fullStr | Cohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA |
| title_full_unstemmed | Cohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA |
| title_short | Cohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA |
| title_sort | cohort profile study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the usa |
| url | https://bmjopen.bmj.com/content/14/8/e081201.full |
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