Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen
Despite the human immunodeficiency virus (HIV) pandemic continuing worldwide for 40 years, no vaccine to combat the disease has been licenced for use in at risk populations. Here, we describe a novel recombinant vesicular stomatitis virus (rVSV) vector vaccine expressing modified HIV envelope glycop...
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2251595 |
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| author | Joseph Jelinski Monika M. Kowatsch Marc-Alexandre Lafrance Alice Berger Jannie Pedersen Hiva Azizi Yue Li Florine Scholte Alejandro Gomez Natasha Hollett Toby Le Matthew Wade Hugues Fausther-Bovendo Marc-Antoine de La Vega George Babuadze Ara Claude Lamarre Trina Racine Chil-Yong Kang Xiao-Jian Yao Galit Alter Eric Arts Keith R. Fowke Gary P. Kobinger |
| author_facet | Joseph Jelinski Monika M. Kowatsch Marc-Alexandre Lafrance Alice Berger Jannie Pedersen Hiva Azizi Yue Li Florine Scholte Alejandro Gomez Natasha Hollett Toby Le Matthew Wade Hugues Fausther-Bovendo Marc-Antoine de La Vega George Babuadze Ara Claude Lamarre Trina Racine Chil-Yong Kang Xiao-Jian Yao Galit Alter Eric Arts Keith R. Fowke Gary P. Kobinger |
| author_sort | Joseph Jelinski |
| collection | DOAJ |
| description | Despite the human immunodeficiency virus (HIV) pandemic continuing worldwide for 40 years, no vaccine to combat the disease has been licenced for use in at risk populations. Here, we describe a novel recombinant vesicular stomatitis virus (rVSV) vector vaccine expressing modified HIV envelope glycoproteins and Ebola virus glycoprotein. Three heterologous immunizations successfully prevented infection by a different clade SHIV in 60% of non-human primates (NHPs). No trend was observed between resistance and antibody interactions. Resistance to infection was associated with high proportions of central memory T-cell CD69 and CD154 marker upregulation, increased IL-2 production, and a reduced IFN-γ response, offering insight into correlates of protection. |
| format | Article |
| id | doaj-art-ac4f6afa4e50490f8eb8b4863aced04d |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-ac4f6afa4e50490f8eb8b4863aced04d2025-08-20T02:37:39ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112210.1080/22221751.2023.2251595Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigenJoseph Jelinski0Monika M. Kowatsch1Marc-Alexandre Lafrance2Alice Berger3Jannie Pedersen4Hiva Azizi5Yue Li6Florine Scholte7Alejandro Gomez8Natasha Hollett9Toby Le10Matthew Wade11Hugues Fausther-Bovendo12Marc-Antoine de La Vega13George Babuadze14Ara15Claude Lamarre16Trina Racine17Chil-Yong Kang18Xiao-Jian Yao19Galit Alter20Eric Arts21Keith R. Fowke22Gary P. Kobinger23Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USADepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, CanadaFaculty of Medicine, Université Laval, Quebec City, CanadaDépartement de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, CanadaAxe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, CanadaDépartement de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, CanadaDepartment of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, CanadaDépartement de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, CanadaDépartement de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, CanadaDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, CanadaDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, CanadaAxe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, CanadaDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USADepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USADepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USADepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USAAxe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, CanadaAxe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, CanadaDepartment of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, CanadaDepartment of Medical Microbiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, CanadaRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USADepartment of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, CanadaDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, CanadaDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USADespite the human immunodeficiency virus (HIV) pandemic continuing worldwide for 40 years, no vaccine to combat the disease has been licenced for use in at risk populations. Here, we describe a novel recombinant vesicular stomatitis virus (rVSV) vector vaccine expressing modified HIV envelope glycoproteins and Ebola virus glycoprotein. Three heterologous immunizations successfully prevented infection by a different clade SHIV in 60% of non-human primates (NHPs). No trend was observed between resistance and antibody interactions. Resistance to infection was associated with high proportions of central memory T-cell CD69 and CD154 marker upregulation, increased IL-2 production, and a reduced IFN-γ response, offering insight into correlates of protection.https://www.tandfonline.com/doi/10.1080/22221751.2023.2251595HIVimmunodeficiencyvaccineprophylaxisNHPT-cell |
| spellingShingle | Joseph Jelinski Monika M. Kowatsch Marc-Alexandre Lafrance Alice Berger Jannie Pedersen Hiva Azizi Yue Li Florine Scholte Alejandro Gomez Natasha Hollett Toby Le Matthew Wade Hugues Fausther-Bovendo Marc-Antoine de La Vega George Babuadze Ara Claude Lamarre Trina Racine Chil-Yong Kang Xiao-Jian Yao Galit Alter Eric Arts Keith R. Fowke Gary P. Kobinger Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen Emerging Microbes and Infections HIV immunodeficiency vaccine prophylaxis NHP T-cell |
| title | Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen |
| title_full | Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen |
| title_fullStr | Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen |
| title_full_unstemmed | Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen |
| title_short | Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen |
| title_sort | rhesus macaques show increased resistance to repeated shiv intrarectal exposure following a heterologous regimen of rvsv vector vaccine expressing hiv antigen |
| topic | HIV immunodeficiency vaccine prophylaxis NHP T-cell |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2251595 |
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