COVID-19 pandemic and vaccination rate in patients with psoriasis treated with biologics: A single center experience
Background/Aim. Psoriasis is a chronic, immune-mediated, genetically determined disease, which is manifested by the appearance of erythematous scaly plaques. Treatment includes conventional therapies and biologics. The coronavirus disease 2019 (COVID-19) raised widespread concern for patients with p...
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Military Health Department, Ministry of Defance, Serbia
2024-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502400083M.pdf |
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| author | Milčić Danijela Malinić Marija Ćirković Anđa Krupniković Doroteja Milinković-Srećković Mirjana |
| author_facet | Milčić Danijela Malinić Marija Ćirković Anđa Krupniković Doroteja Milinković-Srećković Mirjana |
| author_sort | Milčić Danijela |
| collection | DOAJ |
| description | Background/Aim. Psoriasis is a chronic, immune-mediated, genetically determined disease, which is manifested by the appearance of erythematous scaly plaques. Treatment includes conventional therapies and biologics. The coronavirus disease 2019 (COVID-19) raised widespread concern for patients with psoriasis treated with immunosuppressive drugs, especially biologics. Even though there was no data at the beginning of the pandemic on the efficacy and safety of vaccines against COVID-19 in patients with psoriasis treated with biologics, the National Psoriasis Foundation (United States of America) recommended vaccination in these patients. The aim of this study was to evaluate the influence of COVID-19 on clinical characteristics and quality of life of psoriatic patients treated with biologics and evaluate the effectiveness of biologic therapy during the pandemic. Methods. A retrospective cross-sectional study was conducted at the Clinic of Dermatology and Venereology of the University Clinical Center of Serbia from March 2020 to January 2022. Data was collected from medical documentation during the consecutive hospitalization of patients with psoriasis who received biologics. Results. The study included a total of 181 patients with psoriasis divided into two groups. Patients from each group were treated with different biologics (ustekinumab in 63.0% and secukinumab in 37.0% of patients). They achieved significant improvement regarding their clinical characteristics after a two-year follow-up [Psoriasis Area and Severity Index (PASI) before treatment: 14.1 (0–50.5) and after treatment: 1.2 (0–49.7), p < 0.001] and quality of life [Dermatology Life Quality Index (DLQI) before treatment: 15.0 (0–34) and after treatment: 0 (0–28), p < 0.001]. Due to unsatisfactory therapeutic response in 4 (2.2%) patients, secukinumab was changed to ustekinumab. The vaccine against COVID-19 was given to 53.0% of patients, but only 20.4% received all three doses. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed in 64 (35.4%) patients, and 68.0% of those infected contracted the disease before the first dose of the vaccine. Therapy with biologics was delayed due to SARS-CoV-2 infection in 52 (28.7%) patients, of which 11 (21.2%) had exacerbation of psoriasis. Conclusion. The vaccination rate in patients with psoriasis receiving biologics was hardly 50.0%, and about a third of the vaccinated patients had a milder form of COVID-19. The therapy with biologics was successful regardless of the short-term interruption of drug administration due to the beginning of the COVID-19 pandemic and the worsening of psoriasis in some patients during that time. |
| format | Article |
| id | doaj-art-ac4f59a501df434cbc2fac27ee0b8671 |
| institution | Kabale University |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
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| series | Vojnosanitetski Pregled |
| spelling | doaj-art-ac4f59a501df434cbc2fac27ee0b86712025-01-30T06:47:05ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202024-01-01811276577110.2298/VSP230903083M0042-84502400083MCOVID-19 pandemic and vaccination rate in patients with psoriasis treated with biologics: A single center experienceMilčić Danijela0https://orcid.org/0009-0003-0453-8174Malinić Marija1https://orcid.org/0000-0002-1021-2053Ćirković Anđa2https://orcid.org/0000-0002-7542-5690Krupniković Doroteja3Milinković-Srećković Mirjana4https://orcid.org/0000-0001-8888-5453University Clinical Center of Serbia, Clinic of Dermatology and Venereology, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Center of Serbia, Clinic of Dermatology and Venereology, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, Serbia + Institute of Medical Statistics and Informatics, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Center of Serbia, Clinic of Dermatology and Venereology, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaBackground/Aim. Psoriasis is a chronic, immune-mediated, genetically determined disease, which is manifested by the appearance of erythematous scaly plaques. Treatment includes conventional therapies and biologics. The coronavirus disease 2019 (COVID-19) raised widespread concern for patients with psoriasis treated with immunosuppressive drugs, especially biologics. Even though there was no data at the beginning of the pandemic on the efficacy and safety of vaccines against COVID-19 in patients with psoriasis treated with biologics, the National Psoriasis Foundation (United States of America) recommended vaccination in these patients. The aim of this study was to evaluate the influence of COVID-19 on clinical characteristics and quality of life of psoriatic patients treated with biologics and evaluate the effectiveness of biologic therapy during the pandemic. Methods. A retrospective cross-sectional study was conducted at the Clinic of Dermatology and Venereology of the University Clinical Center of Serbia from March 2020 to January 2022. Data was collected from medical documentation during the consecutive hospitalization of patients with psoriasis who received biologics. Results. The study included a total of 181 patients with psoriasis divided into two groups. Patients from each group were treated with different biologics (ustekinumab in 63.0% and secukinumab in 37.0% of patients). They achieved significant improvement regarding their clinical characteristics after a two-year follow-up [Psoriasis Area and Severity Index (PASI) before treatment: 14.1 (0–50.5) and after treatment: 1.2 (0–49.7), p < 0.001] and quality of life [Dermatology Life Quality Index (DLQI) before treatment: 15.0 (0–34) and after treatment: 0 (0–28), p < 0.001]. Due to unsatisfactory therapeutic response in 4 (2.2%) patients, secukinumab was changed to ustekinumab. The vaccine against COVID-19 was given to 53.0% of patients, but only 20.4% received all three doses. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed in 64 (35.4%) patients, and 68.0% of those infected contracted the disease before the first dose of the vaccine. Therapy with biologics was delayed due to SARS-CoV-2 infection in 52 (28.7%) patients, of which 11 (21.2%) had exacerbation of psoriasis. Conclusion. The vaccination rate in patients with psoriasis receiving biologics was hardly 50.0%, and about a third of the vaccinated patients had a milder form of COVID-19. The therapy with biologics was successful regardless of the short-term interruption of drug administration due to the beginning of the COVID-19 pandemic and the worsening of psoriasis in some patients during that time.https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502400083M.pdfbiological therapycovid-19psoriasisvaccination |
| spellingShingle | Milčić Danijela Malinić Marija Ćirković Anđa Krupniković Doroteja Milinković-Srećković Mirjana COVID-19 pandemic and vaccination rate in patients with psoriasis treated with biologics: A single center experience Vojnosanitetski Pregled biological therapy covid-19 psoriasis vaccination |
| title | COVID-19 pandemic and vaccination rate in patients with psoriasis treated with biologics: A single center experience |
| title_full | COVID-19 pandemic and vaccination rate in patients with psoriasis treated with biologics: A single center experience |
| title_fullStr | COVID-19 pandemic and vaccination rate in patients with psoriasis treated with biologics: A single center experience |
| title_full_unstemmed | COVID-19 pandemic and vaccination rate in patients with psoriasis treated with biologics: A single center experience |
| title_short | COVID-19 pandemic and vaccination rate in patients with psoriasis treated with biologics: A single center experience |
| title_sort | covid 19 pandemic and vaccination rate in patients with psoriasis treated with biologics a single center experience |
| topic | biological therapy covid-19 psoriasis vaccination |
| url | https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502400083M.pdf |
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