The association between serum uric acid levels and the cardiometabolic phenotype among healthcare workers of Tabriz University of Medical Sciences
Introduction: It is unclear whether hyperuricemia can be considered as an independent risk factor or just as a marker to represent the correlation between uric acid levels and other risk factors of MetS. In this work, we intend to study the correlation between serum uric acid (SUA) and the cardiomet...
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Tabriz University of Medical Sciences
2025-03-01
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| Series: | Journal of Cardiovascular and Thoracic Research |
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| Online Access: | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-17-40.pdf |
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| author | Mohammadhossein Somi Negin Frounchi Seyed Sina Zakavi Alireza Ostadrahimi Neda Gilani Elnaz Faramarzi Sarvin Sanaie |
| author_facet | Mohammadhossein Somi Negin Frounchi Seyed Sina Zakavi Alireza Ostadrahimi Neda Gilani Elnaz Faramarzi Sarvin Sanaie |
| author_sort | Mohammadhossein Somi |
| collection | DOAJ |
| description | Introduction: It is unclear whether hyperuricemia can be considered as an independent risk factor or just as a marker to represent the correlation between uric acid levels and other risk factors of MetS. In this work, we intend to study the correlation between serum uric acid (SUA) and the cardiometabolic phenotype among Tabriz University of Medical Science healthcare workers. Methods: In this cross-sectional study, anthropometric measurements, serum fasting blood sugar (FBS), triglyceride (TG), cholesterol, high-density lipoprotein (HDL), liver enzymes, blood urea nitrogen (BUN), SUA, creatinine (Cr), and blood pressures of 1,451 healthcare workers were evaluated. MetS was diagnosed based on ATP III. We classified the participants into four cardiometabolic phenotypes: metabolically-healthy lean (MHL), metabolically-unhealthy lean (MUHL), metabolically-healthy obese (MHO), and metabolically-unhealthy obese (MUHO). Results: MHL (26.6%) and MHO (65.8 %) had the highest prevalence rates in the first and second SUA categories, respectively (P≤0.001). Compared to the lowest SUA category, the odds of MHO and MUHO increased by 3.13 (95% CI 2.21–4.44) and 5.50 (95%CI 3.53–8.57) in the highest category, respectively. This trend was not observed regarding the association between MUHL and the SUA classification. Conclusion: We propose using the easily-measured SUA level as a marker for early diagnosis of at-risk MUHL and MHO individuals to administer proper interventions. Further prospective studies are needed to identify the effects of SUA on the progression of MetS in various body-size subgroups. |
| format | Article |
| id | doaj-art-ac4aaf53d3ae45ccaa958c73586d771a |
| institution | DOAJ |
| issn | 2008-5117 2008-6830 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardiovascular and Thoracic Research |
| spelling | doaj-art-ac4aaf53d3ae45ccaa958c73586d771a2025-08-20T02:57:12ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302025-03-01171404810.34172/jcvtr.32902jcvtr-32902The association between serum uric acid levels and the cardiometabolic phenotype among healthcare workers of Tabriz University of Medical SciencesMohammadhossein Somi0Negin Frounchi1Seyed Sina Zakavi2Alireza Ostadrahimi3Neda Gilani4Elnaz Faramarzi5Sarvin Sanaie6Liver and Gastrointestinal Diseases Research Center of Tabriz University of Medical Sciences, Tabriz, IranStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, IranStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, IranNutrition Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, IranLiver and Gastrointestinal Diseases Research Center of Tabriz University of Medical Sciences, Tabriz, IranNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, IranIntroduction: It is unclear whether hyperuricemia can be considered as an independent risk factor or just as a marker to represent the correlation between uric acid levels and other risk factors of MetS. In this work, we intend to study the correlation between serum uric acid (SUA) and the cardiometabolic phenotype among Tabriz University of Medical Science healthcare workers. Methods: In this cross-sectional study, anthropometric measurements, serum fasting blood sugar (FBS), triglyceride (TG), cholesterol, high-density lipoprotein (HDL), liver enzymes, blood urea nitrogen (BUN), SUA, creatinine (Cr), and blood pressures of 1,451 healthcare workers were evaluated. MetS was diagnosed based on ATP III. We classified the participants into four cardiometabolic phenotypes: metabolically-healthy lean (MHL), metabolically-unhealthy lean (MUHL), metabolically-healthy obese (MHO), and metabolically-unhealthy obese (MUHO). Results: MHL (26.6%) and MHO (65.8 %) had the highest prevalence rates in the first and second SUA categories, respectively (P≤0.001). Compared to the lowest SUA category, the odds of MHO and MUHO increased by 3.13 (95% CI 2.21–4.44) and 5.50 (95%CI 3.53–8.57) in the highest category, respectively. This trend was not observed regarding the association between MUHL and the SUA classification. Conclusion: We propose using the easily-measured SUA level as a marker for early diagnosis of at-risk MUHL and MHO individuals to administer proper interventions. Further prospective studies are needed to identify the effects of SUA on the progression of MetS in various body-size subgroups.https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-17-40.pdfabdominal obesityuric acidmetabolic syndromebody mass index |
| spellingShingle | Mohammadhossein Somi Negin Frounchi Seyed Sina Zakavi Alireza Ostadrahimi Neda Gilani Elnaz Faramarzi Sarvin Sanaie The association between serum uric acid levels and the cardiometabolic phenotype among healthcare workers of Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research abdominal obesity uric acid metabolic syndrome body mass index |
| title | The association between serum uric acid levels and the cardiometabolic phenotype among healthcare workers of Tabriz University of Medical Sciences |
| title_full | The association between serum uric acid levels and the cardiometabolic phenotype among healthcare workers of Tabriz University of Medical Sciences |
| title_fullStr | The association between serum uric acid levels and the cardiometabolic phenotype among healthcare workers of Tabriz University of Medical Sciences |
| title_full_unstemmed | The association between serum uric acid levels and the cardiometabolic phenotype among healthcare workers of Tabriz University of Medical Sciences |
| title_short | The association between serum uric acid levels and the cardiometabolic phenotype among healthcare workers of Tabriz University of Medical Sciences |
| title_sort | association between serum uric acid levels and the cardiometabolic phenotype among healthcare workers of tabriz university of medical sciences |
| topic | abdominal obesity uric acid metabolic syndrome body mass index |
| url | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-17-40.pdf |
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