Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin Therapy
Age-related retinopathy is one of the leading causes of visual impairment and irreversible blindness, characterized by progressive neuronal and myelin loss. The damages caused by oxidation contributes to the hallmarks of aging and represents fundamental components in pathological pathways that are t...
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MDPI AG
2025-05-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/5/561 |
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| author | Ning Pu Siyu Li Hao Wu Na Zhao Kexin Wang Dong Wei Jiale Wang Lulu Sha Yameng Zhao Ye Tao Zongming Song |
| author_facet | Ning Pu Siyu Li Hao Wu Na Zhao Kexin Wang Dong Wei Jiale Wang Lulu Sha Yameng Zhao Ye Tao Zongming Song |
| author_sort | Ning Pu |
| collection | DOAJ |
| description | Age-related retinopathy is one of the leading causes of visual impairment and irreversible blindness, characterized by progressive neuronal and myelin loss. The damages caused by oxidation contributes to the hallmarks of aging and represents fundamental components in pathological pathways that are thought to drive multiple age-related retinopathies. Quercetin (Que), a natural polyphenol abundant in vegetables, herbs, and fruits, has been extensively studied for its long-term antioxidative effects mediated through diverse mechanisms. Additionally, Que and its derivatives exhibit a broad spectrum of pharmacological characteristics in the cellular responses of age-related retinopathy induced by oxidative stress, including anti-inflammatory, anti-neovascularization, regulatory, and neuroprotective effects in autophagy and apoptosis processes. This review mainly focuses on the antioxidative mechanisms and curative effects of Que treatment for various age-related retinopathies, such as retinitis pigmentosa, diabetic retinopathy, age-related macular degeneration, and glaucoma. Furthermore, we discuss emerging technologies and methods involving Que and its derivatives in the therapeutic strategies for age-related retinopathies, highlighting their promise for clinical translation. |
| format | Article |
| id | doaj-art-ac47e5bf6ebb41bb90134f21b31f22ea |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-ac47e5bf6ebb41bb90134f21b31f22ea2025-08-20T02:33:36ZengMDPI AGAntioxidants2076-39212025-05-0114556110.3390/antiox14050561Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin TherapyNing Pu0Siyu Li1Hao Wu2Na Zhao3Kexin Wang4Dong Wei5Jiale Wang6Lulu Sha7Yameng Zhao8Ye Tao9Zongming Song10Department of Ophthalmology, Henan Eye Hospital, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, ChinaCollege of Medicine, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Ophthalmology, Henan Eye Hospital, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, ChinaCollege of Medicine, Zhengzhou University, Zhengzhou 450001, ChinaCollege of Medicine, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Ophthalmology, Henan Eye Hospital, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, ChinaDepartment of Ophthalmology, Henan Eye Hospital, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, ChinaDepartment of Ophthalmology, Henan Eye Hospital, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, ChinaDepartment of Ophthalmology, Henan Eye Hospital, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, ChinaDepartment of Ophthalmology, Henan Eye Hospital, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, ChinaDepartment of Ophthalmology, Henan Eye Hospital, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, ChinaAge-related retinopathy is one of the leading causes of visual impairment and irreversible blindness, characterized by progressive neuronal and myelin loss. The damages caused by oxidation contributes to the hallmarks of aging and represents fundamental components in pathological pathways that are thought to drive multiple age-related retinopathies. Quercetin (Que), a natural polyphenol abundant in vegetables, herbs, and fruits, has been extensively studied for its long-term antioxidative effects mediated through diverse mechanisms. Additionally, Que and its derivatives exhibit a broad spectrum of pharmacological characteristics in the cellular responses of age-related retinopathy induced by oxidative stress, including anti-inflammatory, anti-neovascularization, regulatory, and neuroprotective effects in autophagy and apoptosis processes. This review mainly focuses on the antioxidative mechanisms and curative effects of Que treatment for various age-related retinopathies, such as retinitis pigmentosa, diabetic retinopathy, age-related macular degeneration, and glaucoma. Furthermore, we discuss emerging technologies and methods involving Que and its derivatives in the therapeutic strategies for age-related retinopathies, highlighting their promise for clinical translation.https://www.mdpi.com/2076-3921/14/5/561oxidative stressage-related retinopathyquercetinpharmacological effects |
| spellingShingle | Ning Pu Siyu Li Hao Wu Na Zhao Kexin Wang Dong Wei Jiale Wang Lulu Sha Yameng Zhao Ye Tao Zongming Song Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin Therapy Antioxidants oxidative stress age-related retinopathy quercetin pharmacological effects |
| title | Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin Therapy |
| title_full | Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin Therapy |
| title_fullStr | Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin Therapy |
| title_full_unstemmed | Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin Therapy |
| title_short | Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin Therapy |
| title_sort | beacon of hope for age related retinopathy antioxidative mechanisms and pre clinical trials of quercetin therapy |
| topic | oxidative stress age-related retinopathy quercetin pharmacological effects |
| url | https://www.mdpi.com/2076-3921/14/5/561 |
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