A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors
Dimensional reduction analysis of available data for white matter of the brain allows to locate the normal (homeostatic), Glioblastoma and Alzheimer's disease attractors in gene expression space and to identify paths related to transitions like carcinogenesis or Alzheimer's disease onset....
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025008254 |
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| author | Joan Nieves Gabriel Gil Augusto Gonzalez |
| author_facet | Joan Nieves Gabriel Gil Augusto Gonzalez |
| author_sort | Joan Nieves |
| collection | DOAJ |
| description | Dimensional reduction analysis of available data for white matter of the brain allows to locate the normal (homeostatic), Glioblastoma and Alzheimer's disease attractors in gene expression space and to identify paths related to transitions like carcinogenesis or Alzheimer's disease onset. A predefined path for aging is also apparent, which is consistent with the hypothesis of programmatic aging. In addition, reasonable assumptions about the relative strengths of attractors allow to draw a schematic landscape of fitness: a Wright's diagram. These simple diagrams reproduce known relations between aging, Glioblastoma and Alzheimer's disease, and rise interesting questions like the possible connection between programmatic aging and Glioblastoma in this tissue. We anticipate that similar multiple diagrams in other tissues could be useful in the understanding of the biology of apparently unrelated diseases or disorders, and in the discovery of unexpected clues for their treatment. |
| format | Article |
| id | doaj-art-ac3ded92d70542b88dd79f0237620959 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-ac3ded92d70542b88dd79f02376209592025-02-11T04:35:15ZengElsevierHeliyon2405-84402025-02-01114e42445A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractorsJoan Nieves0Gabriel Gil1Augusto Gonzalez2Corresponding author.; Institute of Cybernetics, Mathematics and Physics, Havana, CubaInstitute of Cybernetics, Mathematics and Physics, Havana, CubaInstitute of Cybernetics, Mathematics and Physics, Havana, CubaDimensional reduction analysis of available data for white matter of the brain allows to locate the normal (homeostatic), Glioblastoma and Alzheimer's disease attractors in gene expression space and to identify paths related to transitions like carcinogenesis or Alzheimer's disease onset. A predefined path for aging is also apparent, which is consistent with the hypothesis of programmatic aging. In addition, reasonable assumptions about the relative strengths of attractors allow to draw a schematic landscape of fitness: a Wright's diagram. These simple diagrams reproduce known relations between aging, Glioblastoma and Alzheimer's disease, and rise interesting questions like the possible connection between programmatic aging and Glioblastoma in this tissue. We anticipate that similar multiple diagrams in other tissues could be useful in the understanding of the biology of apparently unrelated diseases or disorders, and in the discovery of unexpected clues for their treatment.http://www.sciencedirect.com/science/article/pii/S2405844025008254Gene expression spaceWhite matter of the brainAgingGlioblastomaAlzheimer's disease |
| spellingShingle | Joan Nieves Gabriel Gil Augusto Gonzalez A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors Heliyon Gene expression space White matter of the brain Aging Glioblastoma Alzheimer's disease |
| title | A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors |
| title_full | A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors |
| title_fullStr | A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors |
| title_full_unstemmed | A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors |
| title_short | A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors |
| title_sort | bird s eye view to the homeostatic alzheimer and glioblastoma attractors |
| topic | Gene expression space White matter of the brain Aging Glioblastoma Alzheimer's disease |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025008254 |
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