Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models
Over the past years, a wide variety of in vivo mouse models have been generated in order to unravel the molecular pathology of Chronic Myeloid Leukemia (CML) and to develop and improve therapeutic approaches. These models range from (conditional) transgenic models, knock-in models, and murine bone m...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1625015 |
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| author | Pallavi Sontakke Jenny Jaques Edo Vellenga Jan Jacob Schuringa |
| author_facet | Pallavi Sontakke Jenny Jaques Edo Vellenga Jan Jacob Schuringa |
| author_sort | Pallavi Sontakke |
| collection | DOAJ |
| description | Over the past years, a wide variety of in vivo mouse models have been generated in order to unravel the molecular pathology of Chronic Myeloid Leukemia (CML) and to develop and improve therapeutic approaches. These models range from (conditional) transgenic models, knock-in models, and murine bone marrow retroviral transduction models followed by transplantation. With the advancement of immunodeficient xenograft models, it has become possible to use human stem/progenitor cells for in vivo studies as well as cells directly derived from CML patients. These models not only mimic CML but also have been instrumental in uncovering various fundamental mechanisms of CML disease progression and tyrosine kinase inhibitor (TKI) resistance. With the availability of iPSC technology, it has become feasible to derive, maintain, and expand CML subclones that are at least genetically identical to those in patients. The following review provides an overview of all murine as well as human xenograft models for CML established till date. |
| format | Article |
| id | doaj-art-ac34a8bd8a1041e9bb36dbc9547aa4ce |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-ac34a8bd8a1041e9bb36dbc9547aa4ce2025-02-03T01:33:01ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/16250151625015Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft ModelsPallavi Sontakke0Jenny Jaques1Edo Vellenga2Jan Jacob Schuringa3Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsOver the past years, a wide variety of in vivo mouse models have been generated in order to unravel the molecular pathology of Chronic Myeloid Leukemia (CML) and to develop and improve therapeutic approaches. These models range from (conditional) transgenic models, knock-in models, and murine bone marrow retroviral transduction models followed by transplantation. With the advancement of immunodeficient xenograft models, it has become possible to use human stem/progenitor cells for in vivo studies as well as cells directly derived from CML patients. These models not only mimic CML but also have been instrumental in uncovering various fundamental mechanisms of CML disease progression and tyrosine kinase inhibitor (TKI) resistance. With the availability of iPSC technology, it has become feasible to derive, maintain, and expand CML subclones that are at least genetically identical to those in patients. The following review provides an overview of all murine as well as human xenograft models for CML established till date.http://dx.doi.org/10.1155/2016/1625015 |
| spellingShingle | Pallavi Sontakke Jenny Jaques Edo Vellenga Jan Jacob Schuringa Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models Stem Cells International |
| title | Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models |
| title_full | Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models |
| title_fullStr | Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models |
| title_full_unstemmed | Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models |
| title_short | Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models |
| title_sort | modeling of chronic myeloid leukemia an overview of in vivo murine and human xenograft models |
| url | http://dx.doi.org/10.1155/2016/1625015 |
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