P4HA1: an important target for treating fibrosis related diseases and cancer
Fibrosis is significantly associated with a wide variety of diseases and is involved in their progression. Fibrosis activated under the influence of different combinations of factors is considered a double-edged sword. Although there has been much research on organ fibrosis in recent years, a variet...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1493420/full |
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| author | Xuewen Yang Dong Zhang Mengmeng Li Yingchun Shao Xiyang Zhang Yongzhi Xue |
| author_facet | Xuewen Yang Dong Zhang Mengmeng Li Yingchun Shao Xiyang Zhang Yongzhi Xue |
| author_sort | Xuewen Yang |
| collection | DOAJ |
| description | Fibrosis is significantly associated with a wide variety of diseases and is involved in their progression. Fibrosis activated under the influence of different combinations of factors is considered a double-edged sword. Although there has been much research on organ fibrosis in recent years, a variety of organ fibrosis diseases and cancers are not well controlled in terms of prevention, treatment, and prognosis. Clinical studies still lack exploration and discovery of effective targets for the pathogenesis of organ fibrosis. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a protein kinase and the synthesis and secretion of collagen are related to the sustained activation of P4HA1. As further studies are being conducted, the potential role of P4HA1 in the development of fibrosis-associated diseases and cancer is becoming clear. Consequently, we conducted a systematic review and discussion on the role of P4HA1 in the pathogenesis of various fibrosis-related diseases and cancers. We reviewed the possible strategies of P4HA1 in the diagnosis and treatment of fibrosis-related diseases and cancers, and analyzed its potential relevance as a biomarker in the diagnosis and treatment of fibrosis-related diseases and cancer. |
| format | Article |
| id | doaj-art-ac30f1fe5d6c44c0b5a638bd47ffe7d1 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-ac30f1fe5d6c44c0b5a638bd47ffe7d12025-08-20T02:12:37ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-11-011510.3389/fphar.2024.14934201493420P4HA1: an important target for treating fibrosis related diseases and cancerXuewen Yang0Dong Zhang1Mengmeng Li2Yingchun Shao3Xiyang Zhang4Yongzhi Xue5Department of Pharmacology, Institute of Pharmacokinetics and Liver Molecular Pharmacology, Baotou Medical College, Baotou, ChinaDepartment of Pharmacology, Institute of Pharmacokinetics and Liver Molecular Pharmacology, Baotou Medical College, Baotou, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, ChinaThe Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao University, Qingdao, ChinaFaculty of Basic Medicine, Chongqing Three Gorges Medical College, Chongqing, ChinaDepartment of Pharmacology, Institute of Pharmacokinetics and Liver Molecular Pharmacology, Baotou Medical College, Baotou, ChinaFibrosis is significantly associated with a wide variety of diseases and is involved in their progression. Fibrosis activated under the influence of different combinations of factors is considered a double-edged sword. Although there has been much research on organ fibrosis in recent years, a variety of organ fibrosis diseases and cancers are not well controlled in terms of prevention, treatment, and prognosis. Clinical studies still lack exploration and discovery of effective targets for the pathogenesis of organ fibrosis. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a protein kinase and the synthesis and secretion of collagen are related to the sustained activation of P4HA1. As further studies are being conducted, the potential role of P4HA1 in the development of fibrosis-associated diseases and cancer is becoming clear. Consequently, we conducted a systematic review and discussion on the role of P4HA1 in the pathogenesis of various fibrosis-related diseases and cancers. We reviewed the possible strategies of P4HA1 in the diagnosis and treatment of fibrosis-related diseases and cancers, and analyzed its potential relevance as a biomarker in the diagnosis and treatment of fibrosis-related diseases and cancer.https://www.frontiersin.org/articles/10.3389/fphar.2024.1493420/fullprolyl 4-hydroxylase subunit alpha 1fibrosiscancercardiovascular diseasesmechanism |
| spellingShingle | Xuewen Yang Dong Zhang Mengmeng Li Yingchun Shao Xiyang Zhang Yongzhi Xue P4HA1: an important target for treating fibrosis related diseases and cancer Frontiers in Pharmacology prolyl 4-hydroxylase subunit alpha 1 fibrosis cancer cardiovascular diseases mechanism |
| title | P4HA1: an important target for treating fibrosis related diseases and cancer |
| title_full | P4HA1: an important target for treating fibrosis related diseases and cancer |
| title_fullStr | P4HA1: an important target for treating fibrosis related diseases and cancer |
| title_full_unstemmed | P4HA1: an important target for treating fibrosis related diseases and cancer |
| title_short | P4HA1: an important target for treating fibrosis related diseases and cancer |
| title_sort | p4ha1 an important target for treating fibrosis related diseases and cancer |
| topic | prolyl 4-hydroxylase subunit alpha 1 fibrosis cancer cardiovascular diseases mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1493420/full |
| work_keys_str_mv | AT xuewenyang p4ha1animportanttargetfortreatingfibrosisrelateddiseasesandcancer AT dongzhang p4ha1animportanttargetfortreatingfibrosisrelateddiseasesandcancer AT mengmengli p4ha1animportanttargetfortreatingfibrosisrelateddiseasesandcancer AT yingchunshao p4ha1animportanttargetfortreatingfibrosisrelateddiseasesandcancer AT xiyangzhang p4ha1animportanttargetfortreatingfibrosisrelateddiseasesandcancer AT yongzhixue p4ha1animportanttargetfortreatingfibrosisrelateddiseasesandcancer |