Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome
Postprandial dyslipidaemia may be a plausible mechanism by which polycystic ovary syndrome (PCOS) increases cardiovascular risk. We sought to investigate whether the postprandial glucose and insulin and lipid and lipoprotein responses, including that of apolipoprotein B-48 (apoB-48) containing chylo...
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/9545239 |
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| author | Tommy Kyaw Tun Anne McGowan Niamh Phelan Neuman Correia Gerard Boran Anna-Louise O’Connor Helen M. Roche James Gibney |
| author_facet | Tommy Kyaw Tun Anne McGowan Niamh Phelan Neuman Correia Gerard Boran Anna-Louise O’Connor Helen M. Roche James Gibney |
| author_sort | Tommy Kyaw Tun |
| collection | DOAJ |
| description | Postprandial dyslipidaemia may be a plausible mechanism by which polycystic ovary syndrome (PCOS) increases cardiovascular risk. We sought to investigate whether the postprandial glucose and insulin and lipid and lipoprotein responses, including that of apolipoprotein B-48 (apoB-48) containing chylomicrons, to a mixed meal are different in obese PCOS women when compared to obese control subjects and whether differences, if any, are related to obesity, insulin resistance (IR), hyperandrogenaemia, or PCOS status. 26 women with PCOS (age 30.4±1.2 years (mean ± SEM), body mass index (BMI) 36.8±1.5 kg/m2) and 26 non-PCOS subjects (age 34.1±0.9 years, BMI 31.5±1.0 kg/m2) were studied before and up to 8 hours following a standard mixed meal. AUC-triglyceride (AUC-TG) was higher and AUC-high-density lipoprotein (AUC-HDL) lower in PCOS women. These differences were not apparent when BMI was accounted for. Insulin sensitivity (SI), AUC-apoB-48, and AUC-apolipoprotein B (AUC-apoB) were found to be independent predictors of AUC-TG, accounting for 55% of the variance. Only AUC-insulin remained significantly elevated following adjustment for BMI. Obesity related IR explains postprandial hypertriglyceridaemia and hyperinsulinaemic responses. Management of obesity in premenopausal women with PCOS is likely to reduce their cardiovascular risk burden. |
| format | Article |
| id | doaj-art-ac2ead528a81497fa25ae55e453f28d8 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ac2ead528a81497fa25ae55e453f28d82025-08-20T02:20:22ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/95452399545239Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary SyndromeTommy Kyaw Tun0Anne McGowan1Niamh Phelan2Neuman Correia3Gerard Boran4Anna-Louise O’Connor5Helen M. Roche6James Gibney7Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, IrelandDepartment of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, IrelandDepartment of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, IrelandDepartment of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, IrelandDepartment of Chemical Pathology, Tallaght Hospital, Tallaght, Dublin 24, IrelandNutrigenomics Research Group, UCD Conway Institute of Biomolecular and Biomedical Research, School of Public Health and Population Science, University College Dublin, Belfield, Dublin 4, IrelandNutrigenomics Research Group, UCD Conway Institute of Biomolecular and Biomedical Research, School of Public Health and Population Science, University College Dublin, Belfield, Dublin 4, IrelandDepartment of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, IrelandPostprandial dyslipidaemia may be a plausible mechanism by which polycystic ovary syndrome (PCOS) increases cardiovascular risk. We sought to investigate whether the postprandial glucose and insulin and lipid and lipoprotein responses, including that of apolipoprotein B-48 (apoB-48) containing chylomicrons, to a mixed meal are different in obese PCOS women when compared to obese control subjects and whether differences, if any, are related to obesity, insulin resistance (IR), hyperandrogenaemia, or PCOS status. 26 women with PCOS (age 30.4±1.2 years (mean ± SEM), body mass index (BMI) 36.8±1.5 kg/m2) and 26 non-PCOS subjects (age 34.1±0.9 years, BMI 31.5±1.0 kg/m2) were studied before and up to 8 hours following a standard mixed meal. AUC-triglyceride (AUC-TG) was higher and AUC-high-density lipoprotein (AUC-HDL) lower in PCOS women. These differences were not apparent when BMI was accounted for. Insulin sensitivity (SI), AUC-apoB-48, and AUC-apolipoprotein B (AUC-apoB) were found to be independent predictors of AUC-TG, accounting for 55% of the variance. Only AUC-insulin remained significantly elevated following adjustment for BMI. Obesity related IR explains postprandial hypertriglyceridaemia and hyperinsulinaemic responses. Management of obesity in premenopausal women with PCOS is likely to reduce their cardiovascular risk burden.http://dx.doi.org/10.1155/2016/9545239 |
| spellingShingle | Tommy Kyaw Tun Anne McGowan Niamh Phelan Neuman Correia Gerard Boran Anna-Louise O’Connor Helen M. Roche James Gibney Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome International Journal of Endocrinology |
| title | Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome |
| title_full | Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome |
| title_fullStr | Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome |
| title_full_unstemmed | Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome |
| title_short | Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome |
| title_sort | obesity and insulin resistance are the main determinants of postprandial lipoprotein dysmetabolism in polycystic ovary syndrome |
| url | http://dx.doi.org/10.1155/2016/9545239 |
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