Risk factors of hypocalcemia after total thyroidectomy. A high volume center experience
IntroductionThyroidectomy is one of the most frequently performed surgical procedures worldwide. The most common complication of total thyroidectomy (TT) in the early postoperative period is hypocalcemia. This study aims to determine the risk factors for postoperative hypocalcemia after TT and to re...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Endocrinology |
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| author | Ömer Faruk İnanç Kenan Çetin Yasin Tosun Hasan Fehmi Küçük |
| author_facet | Ömer Faruk İnanç Kenan Çetin Yasin Tosun Hasan Fehmi Küçük |
| author_sort | Ömer Faruk İnanç |
| collection | DOAJ |
| description | IntroductionThyroidectomy is one of the most frequently performed surgical procedures worldwide. The most common complication of total thyroidectomy (TT) in the early postoperative period is hypocalcemia. This study aims to determine the risk factors for postoperative hypocalcemia after TT and to reveal their clinical value. As a secondary outcome, we assessed the effects of iatrogenic parathyroidectomy, surgical experience, and parathyroid transplantations on prolonged than one month hypocalcemia and intravenous calcium infusion requirement after TT.MethodsWe designed our study as a retrospective cohort study. Two hundred sixty-three patients that underwent total thyroidectomy in a single tertiary endocrine surgery unit were included. Patients are followed up for 6 months. The study performed between April 2014 and March 2015. Patients were divided into two groups according to the presence or absence of hypocalcemia after surgery. All patients who performed total thyroidectomy without lymph node dissection in a single session were initially included in the study cohorts. Thereafter, patients with preoperatively confirmed hyperparathyroidism, hypoparathyroidism/hypocalcemia, had a history of thyroid operation, and postoperatively did not undergo regular follow-up (min. 12 months after surgery) were excluded from the latter analysis.ResultsIn the multivariate analysis we conducted in our study, we found that female gender, preoperative hyperthyroidism, intraoperative parathyroid autotransplantation, and surgical experience were independent risk factors. Some of them are predictable parameters such as surgeon experience and preoperative hyperthyroidism.ConclusionsWe consider that specific theoretical and practical studies on thyroid surgery will reduce postoperative hypocalcemia. |
| format | Article |
| id | doaj-art-ac2bef059de5422fbd754e41cdae9150 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-ac2bef059de5422fbd754e41cdae91502025-08-20T02:57:41ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-05-011610.3389/fendo.2025.15389931538993Risk factors of hypocalcemia after total thyroidectomy. A high volume center experienceÖmer Faruk İnanç0Kenan Çetin1Yasin Tosun2Hasan Fehmi Küçük3General Surgery Department, Anadolu Medical Center In Affiliation With Johns Hopkins Medicine, Istanbul, TürkiyeGeneral Surgery Department, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, TürkiyeGeneral Surgery Department, Kartal Dr. Lutfi Kırdar City Hospital, Istanbul, TürkiyeGeneral Surgery Department, Kartal Dr. Lutfi Kırdar City Hospital, Istanbul, TürkiyeIntroductionThyroidectomy is one of the most frequently performed surgical procedures worldwide. The most common complication of total thyroidectomy (TT) in the early postoperative period is hypocalcemia. This study aims to determine the risk factors for postoperative hypocalcemia after TT and to reveal their clinical value. As a secondary outcome, we assessed the effects of iatrogenic parathyroidectomy, surgical experience, and parathyroid transplantations on prolonged than one month hypocalcemia and intravenous calcium infusion requirement after TT.MethodsWe designed our study as a retrospective cohort study. Two hundred sixty-three patients that underwent total thyroidectomy in a single tertiary endocrine surgery unit were included. Patients are followed up for 6 months. The study performed between April 2014 and March 2015. Patients were divided into two groups according to the presence or absence of hypocalcemia after surgery. All patients who performed total thyroidectomy without lymph node dissection in a single session were initially included in the study cohorts. Thereafter, patients with preoperatively confirmed hyperparathyroidism, hypoparathyroidism/hypocalcemia, had a history of thyroid operation, and postoperatively did not undergo regular follow-up (min. 12 months after surgery) were excluded from the latter analysis.ResultsIn the multivariate analysis we conducted in our study, we found that female gender, preoperative hyperthyroidism, intraoperative parathyroid autotransplantation, and surgical experience were independent risk factors. Some of them are predictable parameters such as surgeon experience and preoperative hyperthyroidism.ConclusionsWe consider that specific theoretical and practical studies on thyroid surgery will reduce postoperative hypocalcemia.https://www.frontiersin.org/articles/10.3389/fendo.2025.1538993/fullhypocalcemiathyroidectomyrisk factorshypoparathryroidismendocrine surgery |
| spellingShingle | Ömer Faruk İnanç Kenan Çetin Yasin Tosun Hasan Fehmi Küçük Risk factors of hypocalcemia after total thyroidectomy. A high volume center experience Frontiers in Endocrinology hypocalcemia thyroidectomy risk factors hypoparathryroidism endocrine surgery |
| title | Risk factors of hypocalcemia after total thyroidectomy. A high volume center experience |
| title_full | Risk factors of hypocalcemia after total thyroidectomy. A high volume center experience |
| title_fullStr | Risk factors of hypocalcemia after total thyroidectomy. A high volume center experience |
| title_full_unstemmed | Risk factors of hypocalcemia after total thyroidectomy. A high volume center experience |
| title_short | Risk factors of hypocalcemia after total thyroidectomy. A high volume center experience |
| title_sort | risk factors of hypocalcemia after total thyroidectomy a high volume center experience |
| topic | hypocalcemia thyroidectomy risk factors hypoparathryroidism endocrine surgery |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1538993/full |
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