C. trachomatis Pgp3 antibody prevalence in young women in England, 1993-2010.
Seroepidemiology of chlamydia can offer study opportunities and insights into cumulative risk of exposure that may contribute to monitoring the frequency of, and control of, genital chlamydia-the most commonly diagnosed STI in England. We undertook retrospective anonymous population-based cross-sect...
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072001&type=printable |
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| author | Paddy Horner Kate Soldan Sueli M Vieira Gillian S Wills Sarah C Woodhall Richard Pebody Anthony Nardone Elaine Stanford Myra O McClure |
| author_facet | Paddy Horner Kate Soldan Sueli M Vieira Gillian S Wills Sarah C Woodhall Richard Pebody Anthony Nardone Elaine Stanford Myra O McClure |
| author_sort | Paddy Horner |
| collection | DOAJ |
| description | Seroepidemiology of chlamydia can offer study opportunities and insights into cumulative risk of exposure that may contribute to monitoring the frequency of, and control of, genital chlamydia-the most commonly diagnosed STI in England. We undertook retrospective anonymous population-based cross-sectional surveys using an indirect IgG ELISA for chlamydia Pgp3 antibody. Sera from 4,732 women aged 17-24 years were tested. Samples were taken at 3-yearly intervals between 1993 and 2002, a period during which other data suggest chlamydia transmission may have been increasing, and from each year between 2007 and 2010. Seroprevalence increased in 17-24 year olds over time between 1993 and 2002. Between 2007 and 2010, age-standardised seroprevalence among 17-24 year olds decreased from 20% (95% CI: 17-23) to 15% (95%CI 12-17) (p = 0.0001). The biggest drop was among 20 to 21 year olds, where seroprevalence decreased from 21% in 2007 to 9% in 2010 (p = 0.002). These seroprevalence data reflect some known features of the epidemiology of chlamydia infection, and show that exposure to antibody-inducing chlamydia infection has declined in recent years. This decline was concurrent with increasing rates of screening for asymptomatic chlamydia. Serology should be explored further as a tool for evaluation of chlamydia control, including chlamydia screening programmes. |
| format | Article |
| id | doaj-art-ac2afd6d57704ef3b72085cf65defb42 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-ac2afd6d57704ef3b72085cf65defb422025-08-20T02:35:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7200110.1371/journal.pone.0072001C. trachomatis Pgp3 antibody prevalence in young women in England, 1993-2010.Paddy HornerKate SoldanSueli M VieiraGillian S WillsSarah C WoodhallRichard PebodyAnthony NardoneElaine StanfordMyra O McClureSeroepidemiology of chlamydia can offer study opportunities and insights into cumulative risk of exposure that may contribute to monitoring the frequency of, and control of, genital chlamydia-the most commonly diagnosed STI in England. We undertook retrospective anonymous population-based cross-sectional surveys using an indirect IgG ELISA for chlamydia Pgp3 antibody. Sera from 4,732 women aged 17-24 years were tested. Samples were taken at 3-yearly intervals between 1993 and 2002, a period during which other data suggest chlamydia transmission may have been increasing, and from each year between 2007 and 2010. Seroprevalence increased in 17-24 year olds over time between 1993 and 2002. Between 2007 and 2010, age-standardised seroprevalence among 17-24 year olds decreased from 20% (95% CI: 17-23) to 15% (95%CI 12-17) (p = 0.0001). The biggest drop was among 20 to 21 year olds, where seroprevalence decreased from 21% in 2007 to 9% in 2010 (p = 0.002). These seroprevalence data reflect some known features of the epidemiology of chlamydia infection, and show that exposure to antibody-inducing chlamydia infection has declined in recent years. This decline was concurrent with increasing rates of screening for asymptomatic chlamydia. Serology should be explored further as a tool for evaluation of chlamydia control, including chlamydia screening programmes.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072001&type=printable |
| spellingShingle | Paddy Horner Kate Soldan Sueli M Vieira Gillian S Wills Sarah C Woodhall Richard Pebody Anthony Nardone Elaine Stanford Myra O McClure C. trachomatis Pgp3 antibody prevalence in young women in England, 1993-2010. PLoS ONE |
| title | C. trachomatis Pgp3 antibody prevalence in young women in England, 1993-2010. |
| title_full | C. trachomatis Pgp3 antibody prevalence in young women in England, 1993-2010. |
| title_fullStr | C. trachomatis Pgp3 antibody prevalence in young women in England, 1993-2010. |
| title_full_unstemmed | C. trachomatis Pgp3 antibody prevalence in young women in England, 1993-2010. |
| title_short | C. trachomatis Pgp3 antibody prevalence in young women in England, 1993-2010. |
| title_sort | c trachomatis pgp3 antibody prevalence in young women in england 1993 2010 |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072001&type=printable |
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