Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis?
OBJECTIVES: We aimed to determine whether mean platelet volume value and/or neutrophil/lymphocyte ratio values are useful as a predictive marker for gestational cholestasis. STUDY DESIGN: Retrospective analysis of the data of patients diagnosed with pregnancy cholestasis between 2018-2019 in a pe...
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| Format: | Article |
| Language: | English |
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Medical Network
2021-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1064 |
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| author | Hasan Eroglu Harun Egemen Tolunay Kemal Sarsmaz Gokcen Orgul Dilek Sahin Aykan Yucel |
| author_facet | Hasan Eroglu Harun Egemen Tolunay Kemal Sarsmaz Gokcen Orgul Dilek Sahin Aykan Yucel |
| author_sort | Hasan Eroglu |
| collection | DOAJ |
| description |
OBJECTIVES: We aimed to determine whether mean platelet volume value and/or neutrophil/lymphocyte ratio values are useful as a predictive marker for gestational cholestasis.
STUDY DESIGN: Retrospective analysis of the data of patients diagnosed with pregnancy cholestasis between 2018-2019 in a perinatology clinic. 352 pregnant women were enrolled in the study (122 pregnant women with Intrahepatic cholestasis as study group and 230 pregnant women with no morbidity as the control group)
RESULTS: Mean platelet volume was significantly higher in pregnant women with intrahepatic cholestasis compared to the healthy controls, 9.30 (7-18) and 8.6 (6.7-11.5), respectively. The neutrophil/lymphocyte ratio was significantly higher in pregnant women with intrahepatic cholestasis compared to the healthy controls, 3.93 (0.46-13.75) and 4.25 (0.87-17.1), respectively. There was a statistically significant difference between the two groups for mean platelet volume (p <0.001). In the roc analysis, 8.85 fL for mean platelet volume had a sensitivity of 65% and a specificity of 59%.
CONCLUSION: When compared with healthy pregnancies, mean platelet volume value in gestational cholestasis increases significantly. However, the predictive strength of mean platelet volume for cholestasis is not strong enough to recommend its usage as a single parameter in clinical practice.
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| format | Article |
| id | doaj-art-ac277c17586346f0bf7ca21b9667c8b9 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-ac277c17586346f0bf7ca21b9667c8b92025-02-11T21:12:56ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182021-08-0127210.21613/GORM.2020.1064Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis?Hasan Eroglu0Harun Egemen Tolunay1Kemal Sarsmaz2Gokcen Orgul3Dilek Sahin4Aykan Yucel5Etlik Zübeyde Hanım Kadın Hastalıkları EAHEtlik Zübeyde Hanım Kadın Hastalıkları EAHEtlik Zübeyde Hanım Kadın Hastalıkları EAHEtlik Zübeyde Hanım Kadın Hastalıkları EAHEtlik Zübeyde Hanım Kadın Hastalıkları EAHEtlik Zübeyde Hanım Kadın Hastalıkları EAH OBJECTIVES: We aimed to determine whether mean platelet volume value and/or neutrophil/lymphocyte ratio values are useful as a predictive marker for gestational cholestasis. STUDY DESIGN: Retrospective analysis of the data of patients diagnosed with pregnancy cholestasis between 2018-2019 in a perinatology clinic. 352 pregnant women were enrolled in the study (122 pregnant women with Intrahepatic cholestasis as study group and 230 pregnant women with no morbidity as the control group) RESULTS: Mean platelet volume was significantly higher in pregnant women with intrahepatic cholestasis compared to the healthy controls, 9.30 (7-18) and 8.6 (6.7-11.5), respectively. The neutrophil/lymphocyte ratio was significantly higher in pregnant women with intrahepatic cholestasis compared to the healthy controls, 3.93 (0.46-13.75) and 4.25 (0.87-17.1), respectively. There was a statistically significant difference between the two groups for mean platelet volume (p <0.001). In the roc analysis, 8.85 fL for mean platelet volume had a sensitivity of 65% and a specificity of 59%. CONCLUSION: When compared with healthy pregnancies, mean platelet volume value in gestational cholestasis increases significantly. However, the predictive strength of mean platelet volume for cholestasis is not strong enough to recommend its usage as a single parameter in clinical practice. https://gorm.com.tr/index.php/GORM/article/view/1064Intrahepatic cholestasis of pregnancyNeutrophil to lymphocyte ratioMean platelet volume |
| spellingShingle | Hasan Eroglu Harun Egemen Tolunay Kemal Sarsmaz Gokcen Orgul Dilek Sahin Aykan Yucel Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis? Gynecology Obstetrics & Reproductive Medicine Intrahepatic cholestasis of pregnancy Neutrophil to lymphocyte ratio Mean platelet volume |
| title | Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis? |
| title_full | Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis? |
| title_fullStr | Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis? |
| title_full_unstemmed | Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis? |
| title_short | Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis? |
| title_sort | are the mean platelet volume and neutrophil lymphocyte ratio predictive for gestational cholestasis |
| topic | Intrahepatic cholestasis of pregnancy Neutrophil to lymphocyte ratio Mean platelet volume |
| url | https://gorm.com.tr/index.php/GORM/article/view/1064 |
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