Proinflammatory Effects of C-Peptide in Different Tissues
Atherosclerosis is well known as an inflammatory disease that can lead to clinical complications such as heart attack or stroke. C-peptide as a cleavage product of proinsulin is in the last few decades known as an active peptide with a number of different effects on microvascular and macrovascular c...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/932725 |
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| _version_ | 1832564984241979392 |
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| author | Dusica Vasic Daniel Walcher |
| author_facet | Dusica Vasic Daniel Walcher |
| author_sort | Dusica Vasic |
| collection | DOAJ |
| description | Atherosclerosis is well known as an inflammatory disease that can lead to clinical complications such as heart attack or stroke. C-peptide as a cleavage product of proinsulin is in the last few decades known as an active peptide with a number of different effects on microvascular and macrovascular complications in type 2 diabetic patients. Patients with insulin resistance and early type 2 diabetes show elevated levels of C-peptide in blood. Several last findings demonstrated deposition of C-peptide in the vessel wall in ApoE-deficient mice and induction of local inflammation. Besides that, C-peptide has proliferative effects on human mesangial cells. This review discusses recently published proinflammatory effects of C-peptide in different tissues. |
| format | Article |
| id | doaj-art-ac259262b82c4b209ce4190a578af8b1 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-ac259262b82c4b209ce4190a578af8b12025-02-03T01:09:41ZengWileyInternational Journal of Inflammation2090-80402042-00992012-01-01201210.1155/2012/932725932725Proinflammatory Effects of C-Peptide in Different TissuesDusica Vasic0Daniel Walcher1Department of Internal Medicine II, Cardiology, University of Ulm, Albert-Einstein-Alle 23, 89081 Ulm, GermanyDepartment of Internal Medicine II, Cardiology, University of Ulm, Albert-Einstein-Alle 23, 89081 Ulm, GermanyAtherosclerosis is well known as an inflammatory disease that can lead to clinical complications such as heart attack or stroke. C-peptide as a cleavage product of proinsulin is in the last few decades known as an active peptide with a number of different effects on microvascular and macrovascular complications in type 2 diabetic patients. Patients with insulin resistance and early type 2 diabetes show elevated levels of C-peptide in blood. Several last findings demonstrated deposition of C-peptide in the vessel wall in ApoE-deficient mice and induction of local inflammation. Besides that, C-peptide has proliferative effects on human mesangial cells. This review discusses recently published proinflammatory effects of C-peptide in different tissues.http://dx.doi.org/10.1155/2012/932725 |
| spellingShingle | Dusica Vasic Daniel Walcher Proinflammatory Effects of C-Peptide in Different Tissues International Journal of Inflammation |
| title | Proinflammatory Effects of C-Peptide in Different Tissues |
| title_full | Proinflammatory Effects of C-Peptide in Different Tissues |
| title_fullStr | Proinflammatory Effects of C-Peptide in Different Tissues |
| title_full_unstemmed | Proinflammatory Effects of C-Peptide in Different Tissues |
| title_short | Proinflammatory Effects of C-Peptide in Different Tissues |
| title_sort | proinflammatory effects of c peptide in different tissues |
| url | http://dx.doi.org/10.1155/2012/932725 |
| work_keys_str_mv | AT dusicavasic proinflammatoryeffectsofcpeptideindifferenttissues AT danielwalcher proinflammatoryeffectsofcpeptideindifferenttissues |