Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population
The macrophage migration inhibitory factor (MIF) is related to the progression of atherosclerosis, which, in turn, is a key factor in the development of acute coronary syndrome (ACS). MIF has a CATT short tandem repeat (STR) at position −794 that might be involved in its expression rate. The aim of...
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| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/704854 |
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| author | Emmanuel Valdés-Alvarado José Francisco Muñoz-Valle Yeminia Valle Elena Sandoval-Pinto Ilian Janet García-González Angélica Valdez-Haro Ulises De la Cruz-Mosso Héctor Enrique Flores-Salinas Jorgé Ramón Padilla-Gutiérrez |
| author_facet | Emmanuel Valdés-Alvarado José Francisco Muñoz-Valle Yeminia Valle Elena Sandoval-Pinto Ilian Janet García-González Angélica Valdez-Haro Ulises De la Cruz-Mosso Héctor Enrique Flores-Salinas Jorgé Ramón Padilla-Gutiérrez |
| author_sort | Emmanuel Valdés-Alvarado |
| collection | DOAJ |
| description | The macrophage migration inhibitory factor (MIF) is related to the progression of atherosclerosis, which, in turn, is a key factor in the development of acute coronary syndrome (ACS). MIF has a CATT short tandem repeat (STR) at position −794 that might be involved in its expression rate. The aim of this study was to investigate the association between the −794 CATT5–8 MIF gene polymorphism and susceptibility to ACS in a western Mexican population. This research included 200 ACS patients classified according to the criteria of the American College of Cardiology (ACC) and 200 healthy subjects (HS). The −794 CATT5–8 MIF gene polymorphism was analyzed using a conventional polymerase chain reaction (PCR) technique. The 6 allele was the most frequent in both groups (ACS: 54% and HS: 57%). The most common genotypes in ACS patients and HS were 6/7 and 6/6, respectively, and a significant association was found between the 6/7 genotype and susceptibility to ACS (68% versus 47% in ACS and HS, resp., P=0.03). We conclude that the 6/7 genotype of the MIF −794 CATT5–8 polymorphism is associated with susceptibility to ACS in a western Mexican population. |
| format | Article |
| id | doaj-art-ac0c0aa07a9d4809be8492fbcb6e590c |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-ac0c0aa07a9d4809be8492fbcb6e590c2025-08-20T02:20:23ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/704854704854Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican PopulationEmmanuel Valdés-Alvarado0José Francisco Muñoz-Valle1Yeminia Valle2Elena Sandoval-Pinto3Ilian Janet García-González4Angélica Valdez-Haro5Ulises De la Cruz-Mosso6Héctor Enrique Flores-Salinas7Jorgé Ramón Padilla-Gutiérrez8Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Edificio Q, Primer Piso, Colonia Independencia, 44350 Guadalajara, JAL, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Edificio Q, Primer Piso, Colonia Independencia, 44350 Guadalajara, JAL, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Edificio Q, Primer Piso, Colonia Independencia, 44350 Guadalajara, JAL, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Edificio Q, Primer Piso, Colonia Independencia, 44350 Guadalajara, JAL, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Edificio Q, Primer Piso, Colonia Independencia, 44350 Guadalajara, JAL, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Edificio Q, Primer Piso, Colonia Independencia, 44350 Guadalajara, JAL, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Edificio Q, Primer Piso, Colonia Independencia, 44350 Guadalajara, JAL, MexicoIMSS, Centro Medico Nacional de Occidente, Belisario Dominguez 1000, Colonia Independencia, 44340 Guadalajara, JAL, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Edificio Q, Primer Piso, Colonia Independencia, 44350 Guadalajara, JAL, MexicoThe macrophage migration inhibitory factor (MIF) is related to the progression of atherosclerosis, which, in turn, is a key factor in the development of acute coronary syndrome (ACS). MIF has a CATT short tandem repeat (STR) at position −794 that might be involved in its expression rate. The aim of this study was to investigate the association between the −794 CATT5–8 MIF gene polymorphism and susceptibility to ACS in a western Mexican population. This research included 200 ACS patients classified according to the criteria of the American College of Cardiology (ACC) and 200 healthy subjects (HS). The −794 CATT5–8 MIF gene polymorphism was analyzed using a conventional polymerase chain reaction (PCR) technique. The 6 allele was the most frequent in both groups (ACS: 54% and HS: 57%). The most common genotypes in ACS patients and HS were 6/7 and 6/6, respectively, and a significant association was found between the 6/7 genotype and susceptibility to ACS (68% versus 47% in ACS and HS, resp., P=0.03). We conclude that the 6/7 genotype of the MIF −794 CATT5–8 polymorphism is associated with susceptibility to ACS in a western Mexican population.http://dx.doi.org/10.1155/2014/704854 |
| spellingShingle | Emmanuel Valdés-Alvarado José Francisco Muñoz-Valle Yeminia Valle Elena Sandoval-Pinto Ilian Janet García-González Angélica Valdez-Haro Ulises De la Cruz-Mosso Héctor Enrique Flores-Salinas Jorgé Ramón Padilla-Gutiérrez Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population Journal of Immunology Research |
| title | Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population |
| title_full | Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population |
| title_fullStr | Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population |
| title_full_unstemmed | Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population |
| title_short | Association between the −794 (CATT)5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population |
| title_sort | association between the 794 catt 5 8 mif gene polymorphism and susceptibility to acute coronary syndrome in a western mexican population |
| url | http://dx.doi.org/10.1155/2014/704854 |
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