White matter microstructural integrity continues to develop from adolescence to young adulthood in mice and humans: Same phenotype, different mechanism
As direct evaluation of a mouse model of human neurodevelopment, adolescent and young adult mice and humans underwent MR diffusion tensor imaging to quantify age-related differences in microstructural integrity of brain white matter fibers. Fractional anisotropy (FA) was greater in older than younge...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | NeuroImage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956023000247 |
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| author | David J. Piekarski Natalie M. Zahr Qingyu Zhao Uran Ferizi Kilian M. Pohl Edith V. Sullivan Adolf Pfefferbaum |
| author_facet | David J. Piekarski Natalie M. Zahr Qingyu Zhao Uran Ferizi Kilian M. Pohl Edith V. Sullivan Adolf Pfefferbaum |
| author_sort | David J. Piekarski |
| collection | DOAJ |
| description | As direct evaluation of a mouse model of human neurodevelopment, adolescent and young adult mice and humans underwent MR diffusion tensor imaging to quantify age-related differences in microstructural integrity of brain white matter fibers. Fractional anisotropy (FA) was greater in older than younger mice and humans. Despite the cross-species commonality, the underlying developmental mechanism differed: whereas evidence for greater axonal extension contributed to higher FA in older mice, evidence for continuing myelination contributed to higher FA in human adolescent development. These differences occurred in the context of species distinctions in overall brain growth: whereas the continued growth of the brain and skull in the murine model can accommodate volume expansion into adulthood, human white matter volume and myelination continue growth into adulthood within a fixed intracranial volume. Appreciation of the similarities and differences in developmental mechanism can enhance the utility of animal models of brain white matter structure, function, and response to exogenous manipulation. |
| format | Article |
| id | doaj-art-ac04b80ce71d47cba820051e83fd1a03 |
| institution | Kabale University |
| issn | 2666-9560 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Reports |
| spelling | doaj-art-ac04b80ce71d47cba820051e83fd1a032025-08-20T03:24:30ZengElsevierNeuroImage: Reports2666-95602023-09-013310017910.1016/j.ynirp.2023.100179White matter microstructural integrity continues to develop from adolescence to young adulthood in mice and humans: Same phenotype, different mechanismDavid J. Piekarski0Natalie M. Zahr1Qingyu Zhao2Uran Ferizi3Kilian M. Pohl4Edith V. Sullivan5Adolf Pfefferbaum6Center for Health Science, SRI International, 333 Ravenswood Ave., Menlo Park, CA, 94015, USA; Corresponding author.Center for Health Science, SRI International, 333 Ravenswood Ave., Menlo Park, CA, 94015, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of, Medicine, 401 Quarry Rd., Stanford, CA, 94305, USADepartment of Psychiatry and Behavioral Sciences, Stanford University School of, Medicine, 401 Quarry Rd., Stanford, CA, 94305, USACenter for Health Science, SRI International, 333 Ravenswood Ave., Menlo Park, CA, 94015, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of, Medicine, 401 Quarry Rd., Stanford, CA, 94305, USADepartment of Psychiatry and Behavioral Sciences, Stanford University School of, Medicine, 401 Quarry Rd., Stanford, CA, 94305, USADepartment of Psychiatry and Behavioral Sciences, Stanford University School of, Medicine, 401 Quarry Rd., Stanford, CA, 94305, USACenter for Health Science, SRI International, 333 Ravenswood Ave., Menlo Park, CA, 94015, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of, Medicine, 401 Quarry Rd., Stanford, CA, 94305, USAAs direct evaluation of a mouse model of human neurodevelopment, adolescent and young adult mice and humans underwent MR diffusion tensor imaging to quantify age-related differences in microstructural integrity of brain white matter fibers. Fractional anisotropy (FA) was greater in older than younger mice and humans. Despite the cross-species commonality, the underlying developmental mechanism differed: whereas evidence for greater axonal extension contributed to higher FA in older mice, evidence for continuing myelination contributed to higher FA in human adolescent development. These differences occurred in the context of species distinctions in overall brain growth: whereas the continued growth of the brain and skull in the murine model can accommodate volume expansion into adulthood, human white matter volume and myelination continue growth into adulthood within a fixed intracranial volume. Appreciation of the similarities and differences in developmental mechanism can enhance the utility of animal models of brain white matter structure, function, and response to exogenous manipulation.http://www.sciencedirect.com/science/article/pii/S2666956023000247AdolescenceDevelopmentDiffusion tensor imagingHumanMouseTranslational |
| spellingShingle | David J. Piekarski Natalie M. Zahr Qingyu Zhao Uran Ferizi Kilian M. Pohl Edith V. Sullivan Adolf Pfefferbaum White matter microstructural integrity continues to develop from adolescence to young adulthood in mice and humans: Same phenotype, different mechanism NeuroImage: Reports Adolescence Development Diffusion tensor imaging Human Mouse Translational |
| title | White matter microstructural integrity continues to develop from adolescence to young adulthood in mice and humans: Same phenotype, different mechanism |
| title_full | White matter microstructural integrity continues to develop from adolescence to young adulthood in mice and humans: Same phenotype, different mechanism |
| title_fullStr | White matter microstructural integrity continues to develop from adolescence to young adulthood in mice and humans: Same phenotype, different mechanism |
| title_full_unstemmed | White matter microstructural integrity continues to develop from adolescence to young adulthood in mice and humans: Same phenotype, different mechanism |
| title_short | White matter microstructural integrity continues to develop from adolescence to young adulthood in mice and humans: Same phenotype, different mechanism |
| title_sort | white matter microstructural integrity continues to develop from adolescence to young adulthood in mice and humans same phenotype different mechanism |
| topic | Adolescence Development Diffusion tensor imaging Human Mouse Translational |
| url | http://www.sciencedirect.com/science/article/pii/S2666956023000247 |
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