The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent cause of dementia and a significant contributor to health issues and mortality among older individuals. This condition involves a progressive deterioration in cognitive function and the onset of dementia. Recent advancements suggest that the development...
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IMR Press
2025-02-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/30/2/10.31083/FBL25551 |
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| author | Rayees Ahmad Naik Mehak Naseer Mir Ishfaq Ahmad Malik Rima Bhardwaj Fahad M Alshabrmi Mahmoud Abdulrahman Mahmoud Majid Alhomrani Abdulhakeem S. Alamri Walaa F. Alsanie Ahmed Hjazi Tanmoy Ghatak Burkhard Poeggeler Mahendra P Singh Gopenath TS Sandeep Kumar Singh |
| author_facet | Rayees Ahmad Naik Mehak Naseer Mir Ishfaq Ahmad Malik Rima Bhardwaj Fahad M Alshabrmi Mahmoud Abdulrahman Mahmoud Majid Alhomrani Abdulhakeem S. Alamri Walaa F. Alsanie Ahmed Hjazi Tanmoy Ghatak Burkhard Poeggeler Mahendra P Singh Gopenath TS Sandeep Kumar Singh |
| author_sort | Rayees Ahmad Naik |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the most prevalent cause of dementia and a significant contributor to health issues and mortality among older individuals. This condition involves a progressive deterioration in cognitive function and the onset of dementia. Recent advancements suggest that the development of AD is more intricate than its underlying brain abnormalities alone. In addition, Alzheimer’s disease, metabolic syndrome, and oxidative stress are all intricately linked to one another. Increased concentrations of circulating lipids and disturbances in glucose homeostasis contribute to the intensification of lipid oxidation, leading to a gradual depletion of the body’s antioxidant defenses. This heightened oxidative metabolism adversely impacts cell integrity, resulting in neuronal damage. Pathways commonly acknowledged as contributors to AD pathogenesis include alterations in synaptic plasticity, disorganization of neurons, and cell death. Abnormal metabolism of some membrane proteins is thought to cause the creation of amyloid (Aβ) oligomers, which are extremely hazardous to neurotransmission pathways, especially those involving acetylcholine. The interaction between Aβ oligomers and these neurotransmitter systems is thought to induce cellular dysfunction, an imbalance in neurotransmitter signaling, and, ultimately, the manifestation of neurological symptoms. Antioxidants have a significant impact on human health since they may improve the aging process by combating free radicals. Neurodegenerative diseases are currently incurable; however, they may be effectively managed. An appealing alternative is the utilization of natural antioxidants, such as polyphenols, through diet or dietary supplements, which offer numerous advantages. Within this framework, we have extensively examined the importance of oxidative stress in the advancement of Alzheimer’s disease, as well as the potential influence of antioxidants in mitigating its effects. |
| format | Article |
| id | doaj-art-ac041165860e4192bcb8b56a0747c630 |
| institution | OA Journals |
| issn | 2768-6701 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-ac041165860e4192bcb8b56a0747c6302025-08-20T02:00:29ZengIMR PressFrontiers in Bioscience-Landmark2768-67012025-02-013022555110.31083/FBL25551S2768-6701(24)01467-9The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s DiseaseRayees Ahmad Naik0Mehak Naseer Mir1Ishfaq Ahmad Malik2Rima Bhardwaj3Fahad M Alshabrmi4Mahmoud Abdulrahman Mahmoud5Majid Alhomrani6Abdulhakeem S. Alamri7Walaa F. Alsanie8Ahmed Hjazi9Tanmoy Ghatak10Burkhard Poeggeler11Mahendra P Singh12Gopenath TS13Sandeep Kumar Singh14Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya Sagar, 470003 Sagar, Madhya Pradesh, IndiaNIMS Institute of Allied Medical Science, National Institute of Medical Sciences (NIMS), 303121 Jaipur, Rajasthan, IndiaDepartment of Zoology, Bar. Ramrao Deshmukh Arts, Smt. Indiraji Kapadia Commerce & Nya. Krishnarao Deshmukh Science College, 444701 Amravati, Maharashtra, IndiaDepartment of Chemistry Poona College, Savitribai Phule Pune University, 411007 Pune, Maharashtra, IndiaDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, 51452 Buraydah, Saudi ArabiaDepartment of Family & Community Medicine, College of Medicine, Imam Muhammad Ibn Saud Islamic University, 13313 Riyadh, Saudi ArabiaDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, 21944 Taif, Saudi ArabiaDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, 21944 Taif, Saudi ArabiaDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, 21944 Taif, Saudi ArabiaDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, 11942 Al-Kharj, Saudi ArabiaDepartment of Emergency Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, 226014 Lucknow, Uttar Pradesh, IndiaDepartment of Physiology, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, Faculty of Biology Georg August University Göttingen, Göttingen and Goettingen Research Campus, D-38524 Sassenburg, GermanyDepartment of Zoology, Deen Dayal Upadhyaya Gorakhpur University, 273009 Gorakhpur, Uttar Pradesh, IndiaDepartment of Biotechnology & Bioinformatics, JSS Academy of Higher Education & Research, 570015 Mysuru, Karnataka, IndiaIndian Scientific Education and Technology Foundation, 226001 Lucknow, Uttar Pradesh, IndiaAlzheimer’s disease (AD) is the most prevalent cause of dementia and a significant contributor to health issues and mortality among older individuals. This condition involves a progressive deterioration in cognitive function and the onset of dementia. Recent advancements suggest that the development of AD is more intricate than its underlying brain abnormalities alone. In addition, Alzheimer’s disease, metabolic syndrome, and oxidative stress are all intricately linked to one another. Increased concentrations of circulating lipids and disturbances in glucose homeostasis contribute to the intensification of lipid oxidation, leading to a gradual depletion of the body’s antioxidant defenses. This heightened oxidative metabolism adversely impacts cell integrity, resulting in neuronal damage. Pathways commonly acknowledged as contributors to AD pathogenesis include alterations in synaptic plasticity, disorganization of neurons, and cell death. Abnormal metabolism of some membrane proteins is thought to cause the creation of amyloid (Aβ) oligomers, which are extremely hazardous to neurotransmission pathways, especially those involving acetylcholine. The interaction between Aβ oligomers and these neurotransmitter systems is thought to induce cellular dysfunction, an imbalance in neurotransmitter signaling, and, ultimately, the manifestation of neurological symptoms. Antioxidants have a significant impact on human health since they may improve the aging process by combating free radicals. Neurodegenerative diseases are currently incurable; however, they may be effectively managed. An appealing alternative is the utilization of natural antioxidants, such as polyphenols, through diet or dietary supplements, which offer numerous advantages. Within this framework, we have extensively examined the importance of oxidative stress in the advancement of Alzheimer’s disease, as well as the potential influence of antioxidants in mitigating its effects.https://www.imrpress.com/journal/FBL/30/2/10.31083/FBL25551alzheimer’s diseaseamyloid-betaamyloid plaquesreactive oxygen speciesantioxidantstau protein |
| spellingShingle | Rayees Ahmad Naik Mehak Naseer Mir Ishfaq Ahmad Malik Rima Bhardwaj Fahad M Alshabrmi Mahmoud Abdulrahman Mahmoud Majid Alhomrani Abdulhakeem S. Alamri Walaa F. Alsanie Ahmed Hjazi Tanmoy Ghatak Burkhard Poeggeler Mahendra P Singh Gopenath TS Sandeep Kumar Singh The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease Frontiers in Bioscience-Landmark alzheimer’s disease amyloid-beta amyloid plaques reactive oxygen species antioxidants tau protein |
| title | The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease |
| title_full | The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease |
| title_fullStr | The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease |
| title_full_unstemmed | The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease |
| title_short | The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease |
| title_sort | potential mechanism and the role of antioxidants in mitigating oxidative stress in alzheimer s disease |
| topic | alzheimer’s disease amyloid-beta amyloid plaques reactive oxygen species antioxidants tau protein |
| url | https://www.imrpress.com/journal/FBL/30/2/10.31083/FBL25551 |
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