Chronic bacterial and parasitic infections and cancer: a review
Background: A relatively underestimated facet of infectious diseases is the association of chronic bacterial and parasitic infections with cancer development. Therefore, we sought to evaluate the evidence regarding the association of such infections with the development of malignancy, excluding the...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2010-05-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/819 |
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| author | Vassilis Samaras Petros I. Rafailidis Eleni G. Mourtzoukou George Peppas Matthew E Falagas |
| author_facet | Vassilis Samaras Petros I. Rafailidis Eleni G. Mourtzoukou George Peppas Matthew E Falagas |
| author_sort | Vassilis Samaras |
| collection | DOAJ |
| description |
Background: A relatively underestimated facet of infectious diseases is the association of chronic bacterial and parasitic infections with cancer development. Therefore, we sought to evaluate the evidence regarding the association of such infections with the development of malignancy, excluding the overwhelming evidence of the association of Helicobacter pylori and cancer.
Methodology: We searched Pubmed, Cochrane, and Scopus without time limits for relevant articles.
Results: There is evidence that some bacterial and parasitic infections are associated with cancer development. The level of evidence of this association varies from high to low; in any case, a long time interval is mandatory for the development of cancer. A high level of evidence exists for the association of Salmonella Typhi with gallbladder and hepatobiliary carcinoma; Opisthorchis viverrini and Clonorchis sinensis with cholangiocarcinoma; Schistosoma hematobium with bladder cancer; chronic osteomyelitis with squamous cell carcinoma of the skin; and hidradenitis suppurativa with squamous cell carcinoma of the skin. In contrast, the level of evidence regarding the association of Chlamydia spp. with cancer is low. Mycobacterium tuberculosis is associated with lung cancer, albeit probably not etiopathogenetically.
Conclusions: A considerable number of bacterial infections and parasitic infections are associated with the development of cancer. Further research into recognizing additional associations of bacterial and parasitic infections with cancer is mandatory.
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| format | Article |
| id | doaj-art-abf8437ec96d479982f072a8a727e1a9 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2010-05-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-abf8437ec96d479982f072a8a727e1a92025-08-20T03:48:58ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802010-05-0140510.3855/jidc.819Chronic bacterial and parasitic infections and cancer: a reviewVassilis Samaras0Petros I. Rafailidis1Eleni G. Mourtzoukou2George Peppas3Matthew E Falagas4Alfa Institute of Biomedical Sciences (AIBS), Athens, GreeceAlfa Institute of Biomedical Sciences (AIBS), Athens, GreeceAlfa Institute of Biomedical Sciences (AIBS), Athens, GreeceAlfa Institute of Biomedical Sciences (AIBS), Athens, GreeceAlfa Institute of Biomedical Sciences (AIBS), Athens, Greece Background: A relatively underestimated facet of infectious diseases is the association of chronic bacterial and parasitic infections with cancer development. Therefore, we sought to evaluate the evidence regarding the association of such infections with the development of malignancy, excluding the overwhelming evidence of the association of Helicobacter pylori and cancer. Methodology: We searched Pubmed, Cochrane, and Scopus without time limits for relevant articles. Results: There is evidence that some bacterial and parasitic infections are associated with cancer development. The level of evidence of this association varies from high to low; in any case, a long time interval is mandatory for the development of cancer. A high level of evidence exists for the association of Salmonella Typhi with gallbladder and hepatobiliary carcinoma; Opisthorchis viverrini and Clonorchis sinensis with cholangiocarcinoma; Schistosoma hematobium with bladder cancer; chronic osteomyelitis with squamous cell carcinoma of the skin; and hidradenitis suppurativa with squamous cell carcinoma of the skin. In contrast, the level of evidence regarding the association of Chlamydia spp. with cancer is low. Mycobacterium tuberculosis is associated with lung cancer, albeit probably not etiopathogenetically. Conclusions: A considerable number of bacterial infections and parasitic infections are associated with the development of cancer. Further research into recognizing additional associations of bacterial and parasitic infections with cancer is mandatory. https://jidc.org/index.php/journal/article/view/819Salmonella typhiChlamydiaMycobacterium tuberculosisSchistosomaTropheryma whippeliichronic osteomyelitis |
| spellingShingle | Vassilis Samaras Petros I. Rafailidis Eleni G. Mourtzoukou George Peppas Matthew E Falagas Chronic bacterial and parasitic infections and cancer: a review Journal of Infection in Developing Countries Salmonella typhi Chlamydia Mycobacterium tuberculosis Schistosoma Tropheryma whippelii chronic osteomyelitis |
| title | Chronic bacterial and parasitic infections and cancer: a review |
| title_full | Chronic bacterial and parasitic infections and cancer: a review |
| title_fullStr | Chronic bacterial and parasitic infections and cancer: a review |
| title_full_unstemmed | Chronic bacterial and parasitic infections and cancer: a review |
| title_short | Chronic bacterial and parasitic infections and cancer: a review |
| title_sort | chronic bacterial and parasitic infections and cancer a review |
| topic | Salmonella typhi Chlamydia Mycobacterium tuberculosis Schistosoma Tropheryma whippelii chronic osteomyelitis |
| url | https://jidc.org/index.php/journal/article/view/819 |
| work_keys_str_mv | AT vassilissamaras chronicbacterialandparasiticinfectionsandcancerareview AT petrosirafailidis chronicbacterialandparasiticinfectionsandcancerareview AT elenigmourtzoukou chronicbacterialandparasiticinfectionsandcancerareview AT georgepeppas chronicbacterialandparasiticinfectionsandcancerareview AT matthewefalagas chronicbacterialandparasiticinfectionsandcancerareview |