Determination of trunk neural crest cell fate and susceptibility to splicing perturbation by the DLC1-SF3B1-PHF5A splicing complex

Determination of trunk neural crest cell fate and susceptibility to splicing perturbation by the DLC1-SF3B1-PHF5A splicing complex

Abstract How the ubiquitously expressed splicing factors specifically regulate neural crest (NC) development and enhance their vulnerability to splicing perturbations remain poorly understood. Here, we show that NC-specific DLC1, partnering with SF3B1-PHF5A splicing complex, are crucial for determin...

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Main Authors: Zhengfan Zheng, Suisui Guo, Hoi Yau Tam, Jingkai Wang, Yanxia Rao, Man-Ning Hui, May Pui Lai Cheung, Alan Wai Lun Leung, Kelvin K. W. Wong, Rakesh Sharma, Jessica Aijia Liu, Martin Cheung
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62003-6
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