Unraveling DINCH – Induced hepatotoxicity mechanisms via network toxicology and molecular docking with experimental validation

Phthalates, as a class of known endocrine disruptors, have been controversial because of their potential carcinogenicity and toxicity. Diisononyl cyclohexane-1,2-dicarboxylate (DINCH) is considered to be less toxic and more prone to environmental degradation, and is widely used as a substitute for p...

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Bibliographic Details
Main Authors: Jingxin Xin, Changxu Zhou, Ying Wang, Huiqi Chen, Keling Yin, Ling Gao, Shanshan Shao
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Ecotoxicology and Environmental Safety
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Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325006414
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