Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses

Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses

Abstract Multi‐omics datasets can provide molecular insights beyond the sum of individual omics. Various tools have been recently developed to integrate such datasets, but there are limited strategies to systematically extract mechanistic hypotheses from them. Here, we present COSMOS (Causal Oriente...

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Bibliographic Details
Main Authors: Aurelien Dugourd, Christoph Kuppe, Marco Sciacovelli, Enio Gjerga, Attila Gabor, Kristina B. Emdal, Vitor Vieira, Dorte B. Bekker‐Jensen, Jennifer Kranz, Eric.M.J. Bindels, Ana S.H. Costa, Abel Sousa, Pedro Beltrao, Miguel Rocha, Jesper V. Olsen, Christian Frezza, Rafael Kramann, Julio Saez‐Rodriguez
Format: Article
Language:English
Published: Springer Nature 2021-01-01
Series:Molecular Systems Biology
Subjects:
causal reasoning
kidney cancer
metabolism
multi‐omics
signaling
Online Access:https://doi.org/10.15252/msb.20209730
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