The High Prevalence of Negative Hepatitis B Surface Antibody (Anti-HBs) among Pregnant Women in Bandung, Indonesia: A Community-Based Study
Background. Hepatitis B virus (HBV) infection is a disease that creates a high global burden by affecting approximately 3.5% of the total world population. The main transmission of this disease is from mother to child (MTCT). HBV vaccination program was already initiated in Indonesia in 1987. Howeve...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2020/3414869 |
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| author | Dolvy Girawan Raden T. D. Judistiani Nelly A. Risan Muhammad B. Bestari Eka S. Nugraha Yudith S. Ermaya Dwi Prasetyo |
| author_facet | Dolvy Girawan Raden T. D. Judistiani Nelly A. Risan Muhammad B. Bestari Eka S. Nugraha Yudith S. Ermaya Dwi Prasetyo |
| author_sort | Dolvy Girawan |
| collection | DOAJ |
| description | Background. Hepatitis B virus (HBV) infection is a disease that creates a high global burden by affecting approximately 3.5% of the total world population. The main transmission of this disease is from mother to child (MTCT). HBV vaccination program was already initiated in Indonesia in 1987. However, after three decades, the HBV infection prevalence stays stagnant. This study aimed to explore the seroprevalence of HBV markers and the attributable risk factors of pregnant women at risk of transmitting HBV to their offspring. Method. A cross-sectional study was conducted on pregnant women from primary midwifery and obstetric clinics across Bandung, Indonesia, to assess the HBsAg, anti-HBc, and anti-HBs serological markers. Questionnaire-based interviews were used to obtain the sociodemographic determinants. Logistic regression was applied to assess the association of each determinant factor to positive HBsAg or negative anti-HBs as a dependent variable, which was then reported as odds ratios (OR). Results. A total of 196 subjects were recruited with 12/196 (6.1%) of them were positive HBsAg. After exclusions of those with positive HBsAg and anti-HBc, 24/175 (13.7%) women were isolated as positive anti-HBs, leaving 151/175 (86.3%) women with negative anti-HBs who were susceptible to HBV infection. Low body mass index (BMI) less than 18.5 kg/m2 was a risk factor for positive HBsAg with OR=5.850 (95% CI 1.466-23.34), p=0.012. Nevertheless, no significant determinant factor was associated with negative anti-HBs. Conclusion. Most pregnant women in Bandung, Indonesia, are susceptible to HBV infection, as marked by the negative anti-HBs status. |
| format | Article |
| id | doaj-art-abecd24d279840c88bd9602a4e927c3c |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-abecd24d279840c88bd9602a4e927c3c2025-08-20T03:39:13ZengWileyInternational Journal of Hepatology2090-34482090-34562020-01-01202010.1155/2020/34148693414869The High Prevalence of Negative Hepatitis B Surface Antibody (Anti-HBs) among Pregnant Women in Bandung, Indonesia: A Community-Based StudyDolvy Girawan0Raden T. D. Judistiani1Nelly A. Risan2Muhammad B. Bestari3Eka S. Nugraha4Yudith S. Ermaya5Dwi Prasetyo6Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung 40161, IndonesiaCentre of Immunology Studies, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, IndonesiaDepartment of Child Health, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung 40161, IndonesiaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung 40161, IndonesiaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung 40161, IndonesiaCentre of Immunology Studies, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, IndonesiaCentre of Immunology Studies, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, IndonesiaBackground. Hepatitis B virus (HBV) infection is a disease that creates a high global burden by affecting approximately 3.5% of the total world population. The main transmission of this disease is from mother to child (MTCT). HBV vaccination program was already initiated in Indonesia in 1987. However, after three decades, the HBV infection prevalence stays stagnant. This study aimed to explore the seroprevalence of HBV markers and the attributable risk factors of pregnant women at risk of transmitting HBV to their offspring. Method. A cross-sectional study was conducted on pregnant women from primary midwifery and obstetric clinics across Bandung, Indonesia, to assess the HBsAg, anti-HBc, and anti-HBs serological markers. Questionnaire-based interviews were used to obtain the sociodemographic determinants. Logistic regression was applied to assess the association of each determinant factor to positive HBsAg or negative anti-HBs as a dependent variable, which was then reported as odds ratios (OR). Results. A total of 196 subjects were recruited with 12/196 (6.1%) of them were positive HBsAg. After exclusions of those with positive HBsAg and anti-HBc, 24/175 (13.7%) women were isolated as positive anti-HBs, leaving 151/175 (86.3%) women with negative anti-HBs who were susceptible to HBV infection. Low body mass index (BMI) less than 18.5 kg/m2 was a risk factor for positive HBsAg with OR=5.850 (95% CI 1.466-23.34), p=0.012. Nevertheless, no significant determinant factor was associated with negative anti-HBs. Conclusion. Most pregnant women in Bandung, Indonesia, are susceptible to HBV infection, as marked by the negative anti-HBs status.http://dx.doi.org/10.1155/2020/3414869 |
| spellingShingle | Dolvy Girawan Raden T. D. Judistiani Nelly A. Risan Muhammad B. Bestari Eka S. Nugraha Yudith S. Ermaya Dwi Prasetyo The High Prevalence of Negative Hepatitis B Surface Antibody (Anti-HBs) among Pregnant Women in Bandung, Indonesia: A Community-Based Study International Journal of Hepatology |
| title | The High Prevalence of Negative Hepatitis B Surface Antibody (Anti-HBs) among Pregnant Women in Bandung, Indonesia: A Community-Based Study |
| title_full | The High Prevalence of Negative Hepatitis B Surface Antibody (Anti-HBs) among Pregnant Women in Bandung, Indonesia: A Community-Based Study |
| title_fullStr | The High Prevalence of Negative Hepatitis B Surface Antibody (Anti-HBs) among Pregnant Women in Bandung, Indonesia: A Community-Based Study |
| title_full_unstemmed | The High Prevalence of Negative Hepatitis B Surface Antibody (Anti-HBs) among Pregnant Women in Bandung, Indonesia: A Community-Based Study |
| title_short | The High Prevalence of Negative Hepatitis B Surface Antibody (Anti-HBs) among Pregnant Women in Bandung, Indonesia: A Community-Based Study |
| title_sort | high prevalence of negative hepatitis b surface antibody anti hbs among pregnant women in bandung indonesia a community based study |
| url | http://dx.doi.org/10.1155/2020/3414869 |
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