Transcriptomic profiling of pancreatic neuroendocrine tumors: dysregulation of WNT, MAPK, PI3K, neddylation pathways and potential non-invasive biomarkers.

Transcriptomic profiling of pancreatic neuroendocrine tumors: dysregulation of WNT, MAPK, PI3K, neddylation pathways and potential non-invasive biomarkers.

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The study aimed to identify altered signaling pathways and potential non-invasive biomarkers for pancreatic neuroendocrine tumors (PanNETs) through transcriptomic profiling of tumor tissues. The analysis encompassed samples from non-functional PanNETs (NF-PanNETs), insulinomas, and tumor-adjacent pa...

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Main Authors: Helvijs Niedra, Olesja Rogoza, Rihards Saksis, Raitis Peculis, Anzela Halilova, Aija Gerina, Sofija Vilisova, Natalja Senterjakova, Aldis Pukitis, Ignacio Ruz-Caracuel, Julie Earl, Georgina Kolnikova, Peter Dubovan, Miroslav Tomas, Peter Makovicky, Maria Urbanova, Bozena Smolkova, Eythimios Koniaris, Ioanna Aggelioudaki, Agapi Kataki, Vita Rovite
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0325672
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