Natural Course of Atrophic Gastritis and Intestinal Metaplasia
Atrophic gastritis (AG) and intestinal metaplasia (IM) are considered the main precursor lesions of gastric cancer, and the risk of gastric cancer in the gastric mucosa increases in the presence of AG and IM. The development of intestinal-type gastric adenocarcinoma represents the last step of an in...
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| Format: | Article |
| Language: | English |
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Korean College of Helicobacter and Upper Gastrointestinal Research
2020-06-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
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| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2020-0024.pdf |
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| _version_ | 1850045562374586368 |
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| author | Beom Jin Kim |
| author_facet | Beom Jin Kim |
| author_sort | Beom Jin Kim |
| collection | DOAJ |
| description | Atrophic gastritis (AG) and intestinal metaplasia (IM) are considered the main precursor lesions of gastric cancer, and the risk of gastric cancer in the gastric mucosa increases in the presence of AG and IM. The development of intestinal-type gastric adenocarcinoma represents the last step of an inflammation-metaplasia-dysplasia-carcinoma sequence, called the Correa cascade of multistep gastric carcinogenesis. The incidences of both AG and IM tend to increase with age. Helicobacter pylori is regarded the most important factor in the development of IM; the progression of AG to IM is also affected by numerous environmental factors and individual genetic factors. Therefore, understanding the natural course of AG and IM is very important, especially in areas with a high prevalence of gastric cancer such as Korea. |
| format | Article |
| id | doaj-art-abea592ba358451e9b0b61ee7dc46078 |
| institution | DOAJ |
| issn | 1738-3331 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-abea592ba358451e9b0b61ee7dc460782025-08-20T02:54:40ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312020-06-0120210110610.7704/kjhugr.2020.0024626Natural Course of Atrophic Gastritis and Intestinal MetaplasiaBeom Jin KimAtrophic gastritis (AG) and intestinal metaplasia (IM) are considered the main precursor lesions of gastric cancer, and the risk of gastric cancer in the gastric mucosa increases in the presence of AG and IM. The development of intestinal-type gastric adenocarcinoma represents the last step of an inflammation-metaplasia-dysplasia-carcinoma sequence, called the Correa cascade of multistep gastric carcinogenesis. The incidences of both AG and IM tend to increase with age. Helicobacter pylori is regarded the most important factor in the development of IM; the progression of AG to IM is also affected by numerous environmental factors and individual genetic factors. Therefore, understanding the natural course of AG and IM is very important, especially in areas with a high prevalence of gastric cancer such as Korea.http://www.helicojournal.org/upload/pdf/kjhugr-2020-0024.pdfatrophiccancergastritismetaplasia |
| spellingShingle | Beom Jin Kim Natural Course of Atrophic Gastritis and Intestinal Metaplasia The Korean Journal of Helicobacter and Upper Gastrointestinal Research atrophic cancer gastritis metaplasia |
| title | Natural Course of Atrophic Gastritis and Intestinal Metaplasia |
| title_full | Natural Course of Atrophic Gastritis and Intestinal Metaplasia |
| title_fullStr | Natural Course of Atrophic Gastritis and Intestinal Metaplasia |
| title_full_unstemmed | Natural Course of Atrophic Gastritis and Intestinal Metaplasia |
| title_short | Natural Course of Atrophic Gastritis and Intestinal Metaplasia |
| title_sort | natural course of atrophic gastritis and intestinal metaplasia |
| topic | atrophic cancer gastritis metaplasia |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2020-0024.pdf |
| work_keys_str_mv | AT beomjinkim naturalcourseofatrophicgastritisandintestinalmetaplasia |